The effect of atypical antipsychotic medications in individuals with anorexia nervosa: A systematic review and meta-analysis
Article first published online: 24 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 46, Issue 4, pages 332–339, May 2013
How to Cite
Lebow, J., Sim, L. A., Erwin, P. J. and Murad, M. H. (2013), The effect of atypical antipsychotic medications in individuals with anorexia nervosa: A systematic review and meta-analysis. Int. J. Eat. Disord., 46: 332–339. doi: 10.1002/eat.22059
- Issue published online: 6 APR 2013
- Article first published online: 24 SEP 2012
- Manuscript Accepted: 8 AUG 2012
- anorexia nervosa;
- atypical antipsychotic;
Given that atypical antipsychotic medications have been increasingly prescribed for improving weight gain in anorexia nervosa (AN), we conducted a systematic review and meta-analyses to estimate the influence of atypical antipsychotics on BMI, eating disorder, and psychiatric symptoms in individuals with AN.
Independent reviewers selected studies and extracted study characteristics, methodologic quality, and outcomes for the intention-to-treat group from randomized clinical trials comparing the effect of atypical antipsychotic use to placebo or an active control treatment on BMI.
Compared with placebo, atypical antipsychotics were associated with a nonsignificant increase in BMI (weighted mean difference, WMD = 0.18, 95% CI: −0.36, 0.72; I2 = 26%) and a nonsignificant effect on the drive for thinness and body dissatisfaction. Compared with placebo or active control, these medications led to an increase in anxiety and overall eating disorder symptoms. However, there was a significant reduction over placebo or active control on level of depression. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)