Biological therapies for eating disorders
Article first published online: 9 MAY 2013
Copyright © 2013 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Special Issue: Transformational Science, Transformational Practice: A Special Issue Dedicated to Michael Strober, Editor-In-Chief from 1983 to 2012.
Volume 46, Issue 5, pages 470–477, July 2013
How to Cite
Mitchell, J. E., Roerig, J. and Steffen, K. (2013), Biological therapies for eating disorders. Int. J. Eat. Disord., 46: 470–477. doi: 10.1002/eat.22104
- Issue published online: 9 MAY 2013
- Article first published online: 9 MAY 2013
- Manuscript Accepted: 3 DEC 2012
- National Institutes of Health. Grant Numbers: K23 DK085066, UO1 DK066471, RO1 DK84979
- anorexia nervosa;
- bulimia nervosa;
- binge eating disorder;
- drug treatment
To provide a comprehensive review of pharmacotherapy and other biological treatments for eating disorders.
Literature on this topic was systematically reviewed.
The bulimia nervosa (BN) literature underscores the utility of antidepressants, particularly SSRIs, in improving the symptoms of the disorder. The literature on binge eating disorder supports efficacy on reduction in binge eating frequency for a variety of compounds. However, such compounds have only modest effects on weight. Certain antiepileptic agents such as topiramate, if tolerated, are probably more useful in terms of weight loss. The number of controlled trials in patients with anorexia nervosa (AN) in particular has been quite small, and recent meta-analyses show disappointing results using atypical antipsychotics in AN.
The pharmacological treatment of eating disorders remains an underdeveloped field although drug therapy clearly plays a role in the treatment of those with BN and binge eating disorder. Other biological therapies have not been adequately studied. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:470–477)