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Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration

Authors

  • Ximena Terra PhD,

    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
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  • Teresa Auguet MD, PhD,

    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    2. Servei Medicina Interna, Hospital Universitari Joan XXIII, Tarragona, Spain
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  • Zaida Agüera MSc,

    1. CIBER, Fisiopatología de la Obesidad y Nutricion (CIBERObn), Instituto Carlos III, Spain
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  • Isabel Maria Quesada,

    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
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  • Josep Maria Orellana-Gavaldà PhD,

    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
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  • Carmen Aguilar PhD,

    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
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  • Susana Jiménez-Murcia PhD,

    1. CIBER, Fisiopatología de la Obesidad y Nutricion (CIBERObn), Instituto Carlos III, Spain
    2. Department de Psiquiatria, Hospital Universitari Bellvitge-IDIBELL, Spain
    3. Department de Ciències Clíniques, Universitat de Barcelona, Spain
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  • Alba Berlanga MSc,

    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
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  • Esther Guiu-Jurado MSc,

    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
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  • José Manuel Menchón MD,

    1. Department de Psiquiatria, Hospital Universitari Bellvitge-IDIBELL, Spain
    2. Department de Ciències Clíniques, Universitat de Barcelona, Spain
    3. CIBER, Salud Mental (CIBERSAM), Instituto Carlos III, Spain
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  • Fernando Fernández-Aranda PhD,

    1. CIBER, Fisiopatología de la Obesidad y Nutricion (CIBERObn), Instituto Carlos III, Spain
    2. Department de Psiquiatria, Hospital Universitari Bellvitge-IDIBELL, Spain
    3. Department de Ciències Clíniques, Universitat de Barcelona, Spain
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  • Cristóbal Richart MD, PhD

    Corresponding author
    1. Grup d'estudi de malalties metabòliques associades a insulin resistència (GEMMAIR), Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain
    2. Servei Medicina Interna, Hospital Universitari Joan XXIII, Tarragona, Spain
    • Correspondence to: Dr. Cristóbal Richart, Hospital Universitari de Tarragona Joan XXIII, Mallafré Guasch, 4, 43007 Tarragona, Spain. E-mail:crichart.hj23.ics@gencat.cat

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  • Supported by SAF 2008-02278 (to C.R.) from the Ministerio de Ciencia e Innovación of the Government of Spain

  • Supported by PS09/01778 (to T.A.) and PI11/210 (to F.FA) from the Fondo de Investigación Sanitaria

  • Supported by AGAUR 2009 SGR 959 (to C.R.) and AGAUR 2009 SGR 1554 (to F.FA) from Agència de Gestió d'Ajuts Universitaris i de Recerca

  • Supported by 2010PFR-URV-B2-14 (to C.R.) from Grup GEMMAIR and by the Fundación Biociencia.

  • Ximena Terra and Teresa Auguet contributed equally to this work.

ABSTRACT

Objective

Starvation-induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal-weight controls and their relation with the disease duration and weight restoration.

Method

We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal-weight controls who were eating healthily. We determined by enzyme-linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin-2 (LCN2), leptin, tumor necrosis factor receptor-II (TNFRII), interleukin-6 (IL6), adipocyte fatty acid binding protein-4 (FABP4), ghrelin, and resistin.

Results

The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = −0.372, p = 0.033; r = −0.450, p = 0.038, respectively). Furthermore, the lipid binding-proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = −0.456, p = 0.039; r = −0.536, p = 0.015, respectively).

Discussion

These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:855–861)

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