Diamine oxidase activity levels in anorexia nervosa

Authors

  • Yoshiyuki Takimoto MD, PhD,

    Corresponding author
    1. Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    • Correspondence to: Yoshiyuki Takimoto; Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. E-mail: taki-tky@umin.ac.jp

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  • Kazuhiro Yoshiuchi MD, PhD,

    1. Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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  • Satoshi Shimodaira MD, PhD,

    1. Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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  • Akira Akabayashi MD, PhD

    1. Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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ABSTRACT

Objective

Anorexia nervosa (AN) patients often experience gastrointestinal complications caused by their malnutrition. We hypothesized that intestinal integrity is disturbed in AN. Therefore, the objective of the present study was to investigate serum diamine oxidase (DAO) activity, which is considered to be a clinical indicator of the integrity of the intestinal mucosa, in AN patients.

Method

Thirty-six AN female patients including 21 AN restricting type (AN-R) and 15 AN binge-eating/purging type (AN-BP) were compared with twenty healthy women on serum DAO activity using immunoassay.

Results

DAO levels in AN-R patients were significantly lower than in AN-BP patients and healthy controls.

Discussion

DAO levels were decreased in AN-R patients. This finding suggests the presence of intestinal structural disturbance as one of the physical complications of malnutrition in AN-R patients. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:203–205)

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