Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: No replication found

Authors

  • Margarita C.T. Slof-Op 't Landt PhD,

    Corresponding author
    1. Center for Eating Disorders Ursula, Leidschendam, The Netherlands
    2. Leiden University Medical Centre, Molecular Epidemiology Section (Department of Medical Statistics), Leiden, The Netherlands
    3. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    • Correspondence to: Margarita C.T. Slof-Op 't Landt, Center for Eating Disorders Ursula, PO Box 422, 2260 AK Leidschendam, The Netherlands. E-mail: r.optlandt@centrumeetstoornissen.nl

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  • Eric F. van Furth PhD,

    1. Center for Eating Disorders Ursula, Leidschendam, The Netherlands
    2. Leiden University Medical Centre, Department of Psychiatry, Leiden, The Netherlands
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  • Ingrid Meulenbelt PhD,

    1. Leiden University Medical Centre, Molecular Epidemiology Section (Department of Medical Statistics), Leiden, The Netherlands
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  • Meike Bartels PhD,

    1. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
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  • Jouke Jan Hottenga PhD,

    1. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
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  • P. Eline Slagboom PhD,

    1. Leiden University Medical Centre, Molecular Epidemiology Section (Department of Medical Statistics), Leiden, The Netherlands
    2. Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, The Netherlands
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  • Dorret I. Boomsma PhD

    1. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
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ABSTRACT

Objective

The female preponderance and onset around puberty in the majority of eating disorders (EDs) suggest that sex hormones, like estrogens, may be involved in the onset of these disorders. An eight-SNP haplotype at the estrogen receptor I (ESR1) gene was found to be associated with anorexia nervosa (AN) (Versini et al., Neuropsychopharmacology, 35, 1818–1825, 2010) and three SNPs from this haplotype (rs726281, rs2295193, and rs3798577) were associated with AN and/or EDs. Our objective was to replicate these findings in an independent cohort of 520 patients with an eating disorder, of whom 244 had AN (142 restricting type) from the GenED study and 2,810 random women from the Netherlands Twin Registry.

Method

The frequencies of the eight-SNP haplotype and three ESR1 SNPs were compared between patients with an eating disorder, with AN (restricting type), with bulimia nervosa (BN), and the control women.

Results

Neither the haplotype nor the three ESR1 SNPs were associated with EDs, BN, AN, or restricting type AN.

Discussion

Despite sufficient statistical power, the associations reported by Versini et al. (Neuropsychopharmacology, 35, 1818–1825, 2010) were not replicated. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:211–214)

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