Supported by R01 MH61836 (Keel) and T32 MH093311 (Keel and Eckel) from National Institute of Mental Health.
Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa
Article first published online: 4 MAR 2014
© 2014 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Volume 48, Issue 2, pages 199–205, March 2015
How to Cite
Dossat, A. M., Bodell, L. P., Williams, D. L., Eckel, L. A. and Keel, P. K. (2015), Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa. Int. J. Eat. Disord., 48: 199–205. doi: 10.1002/eat.22264
- Issue published online: 9 FEB 2015
- Article first published online: 4 MAR 2014
- Manuscript Revised: 11 FEB 2014
- Manuscript Accepted: 11 FEB 2014
- Manuscript Received: 18 NOV 2013
- glucagon-like peptide-1;
- bulimia nervosa;
- purging disorder;
- objective binge-eating episode;
- subjective binge-eating episode
This study examined pre- and postprandial glucagon-like peptide 1 (GLP-1) levels in women with bulimia nervosa (BN), purging disorder (PD), and non-eating disorder control women to better understand whether alterations in satiation-related hormones in BN may be linked to binge-eating episodes or other altered ingestive behaviors.
Participants included women with BN (n = 19), PD (n = 14), or controls (n = 14). Participants provided subjective ratings for hunger and fullness and plasma samples before and after consumption of a standardized test meal.
As expected, GLP-1 levels increased significantly following test meal consumption; however, participants with BN displayed significantly lower GLP-1 levels compared to PD and control participants both before and after consumption of the test meal. There were no significant differences between PD and control participants in GLP-1 levels, but individuals with PD displayed significantly higher levels of fullness throughout the test meal as compared to both control and BN participants.
Our findings provide preliminary evidence that reduced GLP-1 levels in individuals with BN may be associated with binge-eating episodes. Additionally, increased fullness in individuals with PD does not appear to be accounted for by exaggerated postprandial GLP-1 release. © 2014 Wiley Periodicals, Inc. Int J Eat Disord 2015; 48:199–205