This article was published online on June 17, 2014. An error was subsequently identified. This notice is included in the online version to indicate that it has been corrected on July 5, 2014.
Effects of obstetric complications on volume and functional connectivity of striatum in anorexia nervosa patients
Article first published online: 17 JUN 2014
© 2014 Wiley Periodicals, Inc.
International Journal of Eating Disorders
Special Issue: Developmental Risk for Eating Disorders across the Lifespan
Volume 47, Issue 7, pages 686–695, November 2014
How to Cite
Favaro, A., Tenconi, E., Degortes, D., Manara, R. and Santonastaso, P. (2014), Effects of obstetric complications on volume and functional connectivity of striatum in anorexia nervosa patients. Int. J. Eat. Disord., 47: 686–695. doi: 10.1002/eat.22320
- Issue published online: 27 OCT 2014
- Article first published online: 17 JUN 2014
- Manuscript Accepted: 3 JUN 2014
- Manuscript Revised: 2 JUN 2014
- Manuscript Received: 27 JAN 2014
- functional connectivity;
- obstetric complications;
- anorexia nervosa
To investigate the volume and functional connectivity of dorsal and ventral striatal nuclei in anorexia nervosa (AN) and their relationship with early exposure to obstetric complications.
Fifty-one patients with lifetime AN (35 acute, 16 recovered) and 34 healthy controls underwent high-resolution and resting-state functional magnetic resonance imaging.
The AN group showed reduced functional connectivity of the putamen compared with healthy women, and this reduction was more evident in patients with lifetime binge eating/purging. Both acute and recovered AN groups showed a larger left accumbens area compared with that of healthy women. The functional connectivity of bilateral nucleus accumbens and putamen showed significant negative correlations with number of obstetric complications in the AN group.
This study supports the hypothesis that AN is associated with structural and functional alterations of striatal networks, and reveals the possible role of obstetric complications in the pathogenesis of striatal dysfunction. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:686–695)