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References

  • References to studies included in this review
  • Alvarez-Cuesta 2005 {published data only}
  • Alvarez-Cuesta E, Aragoneses-Gilsanz E, Martin-Garcia C, Berges-Gimeno P, Gonzalez-Mancebo E, Cuesta-Herranz J. Immunotherapy with depigmented glutaraldehyde-polymerized extracts: changes in quality of life. Clinical and Experimental Allergy 2005;35(5):5728.
  • Ariano 1999 {published data only}
  • Ariano R, Kroon AM, Augeri G, Canonica GW, Passalacqua G. Long-term treatment with allergoid immunotherapy with Parietaria. Clinical and immunologic effects in a randomized, controlled trial.. Allergy 1999;54:3139.
  • Armentia-Medina 1989 {published data only}
  • Armentia-Medina A, Blanco-Quiros A, Martin-Santos JM, Alvarez-Cuesta E, Moneo-Goiri I, Carreira P, et al.Rush immunotherapy with a standardized Bermuda grass pollen extract. Annals of Allergy 1989;63(2):12735.
  • Arvidsson 2002 {published data only}
  • Arvidsson MB, Lowhagen O, Rak S. Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy. Journal of Allergy and Clinical Immunology 2002;109:77783.
  • Balda 1998 {published data only}
  • Balda BR, Wolf H, Baumgarten C, Klimek L, Rasp G, Kunkel G, et al.Tree-pollen allergy is efficiently treated by short-term immunotherapy (SIT) with seven preseasonal injections of molecular standardized allergens. Allergy 1998;53(8):7408.
  • Bodtger 2002 {published data only}
  • Bodtger U, Poulsen LK, Jacobi HH, Malling HJ. The safety and efficacy of subcutaneous birch pollen immunotherapy - a one-year, randomised, double-blind, placebo-controlled study. Allergy 2002;57(4):297305.
  • Bousquet 1987a {published data only}
  • Bousquet J, Hejjaoui A, Skassa-Brociek W, Guerin B, Maasch HJ, Dhivert H, Michel FB. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. I. Rush immunotherapy with allergoids and standardized orchard grass-pollen extract. Journal of Allergy and Clinical Immunology 1987;80(4):5918.
  • Bousquet 1987b {published data only}
  • Bousquet J, Frank E, Soussana M, Hejjaoui A, Maasch HJ, Michel FB. Double-blind, placebo-controlled immunotherapy with a high-molecular-weight, formalinized allergoid in grass pollen allergy. International Archives of Allergy and Applied Immunology 1987;82(3-4):5502.
  • Bousquet 1988 {published data only}
  • Bousquet J, Maasch H, Martinot B, Hejjaoui A, Wahl, Michel FB. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. II Comparison between parameters assessing the efficacy of immunotherapy. Journal of Allergy and Clinical Immunology 1988;82(3 pt 1):43946.
  • Bousquet 1989 {published data only}
  • Bousquet J, Maasch HJ, Hejjaoui A, Skassa-Brociek W, Wahl R, Dhivert H, Michel FB. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. III Efficacy and safety of unfractionated and high-molecular-weight preparations in rhinoconjunctivitis and asthma. Journal of Allergy and Clinical Immunology 1989;84(4 pt 1):54656.
  • Bousquet 1990 {published data only}
  • Bousquet J, Hejjaoui A, Soussana M, Michel FB. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. IV Comparison of the safety and efficacy of two dosages of a high-molecular-weight allergoid. Journal of Allergy and Clinical Immunology 1990;85(2):4907.
  • Bousquet 1991 {published data only}
  • Bousquet J, Becker WM, Hejjaoui A, Chanal I, Lebel B, Dhivert H, Michel FB. Differences in clinical and immunologic reactivity of patients allergic to grass pollens and to multiple-pollen species. II. Efficacy of a double-blind, placebo-controlled, specific immunotherapy with standardized extracts. Journal of Allergy and Clinical Immunology 1991;88(1):4353.
  • Brewczynski 1999 {published data only}
  • Brewczynski PZ, Kroon AM. Efficacy and safety of immunotherapy with modified grass pollen allergens. Results of a placebo-controlled study [Wirksamkeit und vertraglichkeit einer immuntherapie mit modifizierten graserpollenallergenen]. Allergologie 1999;22(7):41120.
  • Brunet 1992a {published data only}
  • Brunet C, Bedard PM, Lavoie A, Jobin M, Hebert J. Allergic rhinitis to ragweed pollen. I. Reassessment of the effects of immunotherapy on cellular and humoral responses. Journal of Allergy and Clinical Immunology 1992;89(1pt 1):7686.
  • Ceuppens 2004 {published data only}
  • Ceuppens J, Kleinjans H, van der Werf J, Rovers M, Stevens W, Jansen A, Zijlker T, Piessens M, Bruggink T, van Durme P. Immunotherapy with a depot birch pollen allergoid. A randomized double-blind placebo-controlled efficacy study [Abstract]. XXIII Congress of the European Academy of Allergology and Clinical Immunology (EAACI). Abstract no. 438. Amsterdam, the Netherlands, 12-16 June. 2004.
  • Charpin 2003 {published data only}
  • Charpin D, Dron M, Fardeau M, Massabie-Bouchat Y, Hugues B, Fabre C, et al.Clinical efficacy of Juniperus ashei specific immunotherapy in European Cypress rhinoconjunctivitis: a double-blind placebo-controlled trial [Abstract]. XXII Congress of the European Academy of Allergology and Clinical Immunology (EAACI). 2003.
  • Corrigan 2005 {published data only}
  • Corrigan CJ, Kettner J, Doemer C, Cromwell O, Narkus A, Study Group. Efficacy and safety of preseasonal-specific immunotherapy with an aluminium-adsorbed six-grass pollen allergoid. Allergy 2005;60(6):8017.
  • D'Amato 1995 {published data only}
  • D'Amato G, Kordash TR, Liccardi G, Lobefalo G, Cazzola M, Freshwater LL. Immunotherapy with Alpare in patients with respiratory allergy to Parietaria pollen: a two year double-blind placebo-controlled study. Clinical and Experimental Allergy 1995;25(2):14958.
  • Dolz 1996 {published data only}
  • Dolz I, Martinez-Cocera C, Bartolome JM, Cimarra M. A double-blind, placebo-controlled study of immunotherapy with grass-pollen extract Alutard SQ during a 3-year period with initial rush immunotherapy. Allergy 1996;51:489500.
  • Drachenberg 2001 {published data only}
  • Drachenberg KJ, Wheeler AW, Stuebner P, Horak F. A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduced allergic symptoms after only four preseasonal injections. Allergy 2001;56:498505.
  • Drachenberg 2002 {published data only}
  • Drachenberg K, Heinzkill M, Urban E. Short-term immunotherapy with tree pollen allergoids and the adjuvant monophosphoryl lipid-A - Results from a multicentre, placebo-controlled, randomised, double-blind study. Allergologie 2002;25(9):46674.
  • Ferrer 2005 {published data only}
  • Ferrer M, Burches E, Pelaez A, Munoz A, Hernandez D, Basomba A, et al.Double-blind, placebo-controlled study of immunotherapy with Parietaria judaica: clinical efficacy and tolerance. Journal of Investigational Allergology and Clinical Immunology 2005;15(4):28392.
  • Fling 1989 {published data only}
  • Fling JA, Ruff ME, Parker WA, Whisman BA, Martin ME, Moss RB, Reid MJ. Suppression of the late cutaneous response by immunotherapy. Journal of Allergy and Clinical Immunology 1989;83(1):1019.
  • Frew 2006 {published data only}
  • Frew AJ, Powell RJ, Corrigan CJ, Durham SR, on behalf of the UK Immunotherapy Study Group. Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis. Journal of Allergy and Clinical Immunology 2006;117:31925.
  • Grammer 1982 {published data only}
  • Grammer LC, Zeiss CR, Suszko IM, Shaughnessy MA, Patterson R. A double-blind, placebo-controlled trial of polymerized whole ragweed for immunotherapy of ragweed allergy. Journal of Allergy and Clinical Immunology 1982;69(6):4949.
  • Grammer 1983 {published data only}
  • Grammer LC, Shaughnessy MA, Suszko IM, Shaughnessy JJ, Patterson R. A double-blind histamine placebo-controlled trial of polymerized whole grass for immunotherapy of grass allergy. Journal of Allergy and Clinical Immunology 1983;72:44853.
  • Grammer 1984a {published data only}
  • Grammer LC, Shaughnessy MA, Suszko IM, Shaughnessy JJ, Patterson R. Persistence of efficacy after a brief course of polymerized ragweed allergen: a controlled study. Journal of Allergy and Clinical Immunology 1984;73(4):4849.
  • Grammer 1984b {published data only}
  • Grammer LC, Shaughnessey MA, Shaughnessy JJ, Patterson R. Asthma as a variable in a study of immunotherapy for allergic rhinitis. Journal of Allergy and Clinical Immunology 1984;73(5 Pt 1):55760.
  • Grammer 1986 {published data only}
  • Grammer LC, Shaughnessy MA, Finkle SM, Shaughnessy JJ, Patterson R. A double-blind placebo-controlled trial of polymerized whole grass administered in an accelerated dosage schedule for immunotherapy of grass pollinosis. Journal of Allergy and Clinical Immunology 1986;78:11804.
  • Grammer 1987 {published data only}
  • Grammer LC, Shaughnessy MA, Bernhard MI, Finkle SM, Pyle HR, Silvestri L, Patterson R. The safety and activity of polymerized ragweed: a double-blind, placebo-controlled trial in 81 patients with ragweed rhinitis. Journal of Allergy and Clinical Immunology 1987;80(2):17783.
  • Hauser 1995 {published data only}
  • Hauser U, Bachert C, Frank E. Inhibitory effect on migration of inflammatory cells into the nasal mucosa by immunotherapy [Hemmung des einstroms von entzundungszellen in die nasenschleimhaut durch die allergen-spezifische immuntherapie]. Allergo Journal 1995;4:16471.
  • Hauser 1997 {published data only}
  • Hauser U, Wagenmann M, Rudack C, Cromwell O, Ganzer U. Specific immunotherapy suppresses IL-1beta and IL-8 levels in nasal secretions: A possible explanation for the inhibition of inflammatory cell migration [Die spezifische immuntherapie reduziert il-1beta und il-8-konzentrationen im nasensekret - eine mogliche erklarung der hammung der einwanderung von entzundungszellen in die nasenschleimhaut]. Otorhinolaryngologia Nova 1997;7(1):319.
  • Iliopoulos 1991 {published data only}
  • Iliopoulos O, Proud D, Adkinson NJ, Creticos PS, Norman PS, Kagey S, Lichtenstein LM, Naclerio RM. Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells. Journal of Allergy and Clinical Immunology 1991;87(4):85566.
  • Juniper 1985 {published data only}
  • Juniper EF, Roberts RS, Kennedy LK, O'Connor J, Syty GM, Dolovich J, Hargreave FE. Polyethylene glycol-modified ragweed pollen extract in rhinoconjunctivitis. Journal of Allergy and Clinical Immunology 1985;75(5):57885.
  • Jutel 2005 {published data only}
  • Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O. Allergen-specific immunotherapy with recombinant grass pollen allergens. Journal of Allergy and Clinical Immunology 2005;116(3):60813.
  • Karmaker 1994 {published data only}
  • Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. International Archives of Allergy and Immunology 1994;103(2):194201.
  • Lee 1982 {published data only}
  • Lee LK, Kniker WT, Campos T. Aggressive coseasonal immunotherapy in mountain cedar pollen allergy. Archives of Otolaryngology 1982;108(12):78794.
  • Leynadier 2001 {published data only}
  • Leynadier F, Banoun L, Dollois B, Terrier P, Epstein M, Guinnepain MT, et al.Immunotherapy with calcium phosphate-adsorbed five-grass-pollen extract in seasonal rhinoconjunctivitis: a double-blind, placebo-controlled study. Clinical and Experimental Allergy 2001;31:98896.
  • Litwin 1991 {published data only}
  • Litwin A, Pesce AJ, Fischer T, Michael M, Michael JG. Regulation of the human immune response to ragweed pollen by immunotherapy. A controlled trial comparing the effect of immunosuppressive peptic fragments of short ragweed with standard treatment. Clinical and Experimental Allergy 1991;21(4):45765.
  • Meriney 1986 {published data only}
  • Meriney DK, Kothari H, Chinoy P, Grieco MH. The clinical and immunologic efficacy of immunotherapy with modified ragweed extract (allergoid) for ragweed hay fever. Annals of Allergy 1986;56(1):348.
  • Metzger 1981 {published data only}
  • Metzger WJ, Clay DH, Richerson HB, Weiler JM, Donnelly A, Moran D. Clinical and immunologic evaluation of glutaraldehyde-modified, tyrosine-adsorbed short ragweed extract: A double-blind, placebo-controlled trial. Journal of Allergy and Clinical Immunology 1981;68(6):4428.
  • Mirone 2004 {published data only}
  • Mirone C, Albert F, Tosi A, Mocchetti F, Mosca S, Giorgino M, Pecora S, Parmiani S, Ortolani C. Efficacy and safety of subcutaneous immunotherapy with a biologically standardized extract of Ambrosia artemisiifolia pollen: a double-blind, placebo-controlled study. Clinical and Experimental Allergy 2004;34(9):140814.
  • Norman 1982 {published data only}
  • Norman PS, Lichtenstein LM, Kagey-Sobotka A, March DG. Controlled evaluation of allergoid in the immunotherapy of ragweed hay fever. Journal of Allergy and Clinical Immunology 1982;70:24860.
  • Ortolani 1984 {published data only}
  • Ortolani C, Pastorello E, Moss RB, Hsu YP, Restuccia M, Joppolo G, et al.Grass pollen immunotherapy: a single year double-blind, placebo-controlled study in patients with grass pollen-induced asthma and rhinitis. Journal of Allergy and Clinical Immunology 1984;73(2):28390.
  • Ortolani 1994 {published data only}
  • Ortolani C, Pastorello EA, Incorvaia C, Ispano M, Farioli L, Zara C, Pravettoni V, Zanussi C. A double-blind, placebo-controlled study of immunotherapy with an alginate-conjugated extract of Parietaria judaica in patients with Parietaria hay fever. Allergy 1994;49:1321.
  • Paraskevopoulos 2005 {published data only}
  • Paraskevopoulos G, Jacobson M, Carr V, Calderon M, Till S, Francis J, Durham S. Grass pollen injection immunotherapy: time course of suppression of allergen-induced late-phase skin responses [Abstract]. Journal of Allergy and Clinical Immunology 2005;115(2 (Suppl 1)):S266.
  • Parker 1989 {published data only}
  • Parker WJ, Whisman B, Apaliski S, Reid M. The relationships between late cutaneous responses and specific antibody responses with outcome of immunotherapy for seasonal allergic rhinitis. Journal of Allergy and Clinical Immunology 1989;84(5 (Pt 1)):66777.
  • Pastorello 1992 {published data only}
  • Pastorello EA, Pravettoni V, Incorvaia C, Mambretti M, Franck E, Wahl R, Zanussi C. Clinical and immunological effects of immunotherapy with alum-absorbed grass allergoid in grass-pollen-induced hay fever. Allergy 1992;47:28190.
  • Tari 1997 {published data only}
  • Tari MG, Mancino M, Ghezzi E, Frank E, Cromwell O. Immunotherapy with an alum-adsorbed Parietaria-pollen allergoid: a 2-year, double-blind, placebo-controlled study. Allergy 1997;52(1):6574.
  • Varney 1991 {published data only}
  • Varney VA, Gaga M, Frew AJ, Aber VR, Kay AB, Durham SR. Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs. British Medical Journal 1991;302(6771):2659.
  • Walker 2001 {published data only}
  • Walker SM, Pajno GB, Torres-Lima M, Wilson DR, Durham SR. Grass pollen immunotherapy for seasonal rhinitis and asthma: a randomized, controlled trial. Journal of Allergy and Clinical Immunology 2001;107:8793.
  • Zenner 1997 {published data only}
  • Zenner HP, Baumgarten C, Rasp G, Fuchs T, Kunkel G, Hauswald B, et al.Short-term immunotherapy: A prospective, randomized, double-blind, placebo-controlled multicenter study of molecular standardized grass and rye allergens in patients with grass pollen-induced allergic rhinitis. Journal of Allergy and Clinical Immunology 1997;100:239.
  • References to studies excluded from this review
  • Aabel 2000 {published data only}
  • Aabel S, Laerum E, Dolvik S, Djupesland P. Is homeopathic 'immunotherapy' effective? A double-blind, placebo-controlled trial with the isopathic remedy Betula 30c for patients with birch pollen allergy. British Homoeopathic Journal 2000;89(4):1618.
  • Adelroth 1999 {published data only}
  • Adelroth E, Sandstrom T, Rak S, Rosenhall L, Zetterstrom O, Aasand O, et al.rhuMAb-E25 (E25) improves quality of life in patients with birch pollen induced seasonal allergic rhinitis. European Respiratory Society. 1999.
  • Adelroth 2000 {published data only}
  • Adelroth E, Rak S, Haahtela T, Aasand G, Rosenhall L, Zetterstrom O, et al.Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen-induded seasonal allergic rhinitis. Journal of Allergy and Clinical Immunology 2000;106:2539.
  • Ancill 1990 {published data only}
  • Ancill R, Takahashi Y, Kibune Y, Campbell R, Smith J. Randomized double-blind, placebo-controlled clinical trial of a selective 5-lipoxygenase inhibitor (AA-861) for the prevention of seasonal allergic rhinitis. Journal of International Medical Research 1990;18(2):7588.
  • Andre 2000 {published data only}
  • Andre C, Vatrinet C, Galvain S, Carat F, Sicard H. Safety of sublingual-swallow immunotherapy in children and adults. International Archives of Allergy and Immunology 2000;121:22934.
  • Astarita 1996 {published data only}
  • Astarita C, Scala G, Sproviero S, Franzese A. Effects of enzyme-potentiated desensitization in the treatment of pollinosis: A double-blind placebo-controlled trial. Journal of Investigational Allergology and Clinical Immunology 1996;6(4):24855.
  • Bacal 1978 {published data only}
  • Bacal E, Zeiss C, Suszko I, et al.Polymerized whole ragweed: An improved method of immunotherapy. Journal of Allergy and Clinical Immunology 1978;62(5):28994.
  • Barrett 2000 {published data only}
  • Barrett J, King M, Pang G. Conditioning rhinitis in allergic humans. Annals of the New York Academy of Sciences 2000;917:8539.
  • Berkovitz 2005 {published data only}
  • Berkovitz, SR. Double blind randomised parallel group placebo controlled study to evaluate the efficacy of enzyme potentiated desensitisation (EPD) in seasonal rhinitis. National Research Register 2005.
  • Bernstein 1976 {published data only}
  • Bernstein I, Tennenbaum J, Georgakis N, Kessler F, Krumholz R. Fraction A: a new immunotherapeutic approach for ragweed pollinosis. International Archives of Allergy and Applied Immunology 1976;50(2):18191.
  • Berstein 2001 {published data only}
  • Berstein C, Deng C, Shuklah R, Berstein J, Bernstein I, Bernstein D. Double blind placebo controlled (DBPC) study of grapeseed extract in the treatment of seasonal allergic rhinitis (SAR). Journal of Allergy and Clinical Immunology 2001;107(2 (Pt 2)):S311.
  • Bochenska 2003 {published data only}
  • Bochenska-Marciniak M, Kupczyk M, Gorski P, Kuna P. The effect of recombinant interleukin-8 on eosinophils' and neutrophils' migration in vivo and in vitro. Allergy 2003;58(8):795801.
  • Bodtger 2003 {published data only}
  • Bodtger U, Poulsen L, Malling H-J. Retrospective assessment of seasonal allergic symptoms: Over-rating but useful. Clinical and Experimental Allergy 2003;33(4):496500.
  • Bolhaar 2004 {published data only}
  • Bolhaar S, Tiemessen M, Zuidmeer L, van Leeuwen A, Hoffmann-Sommergruber K, Bruijnzeel-Koomen C, et al.Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges. Clinical and Experimental Allergy 2004;34(5):7619.
  • Bonifazi 1991 {published data only}
  • Bonifazi F, Antonicelli L, Bilo M, Pucci S, Taylor I, Wheeler A, Youlten L. Hyposensitization therapy of Parietaria-sensitive patients with a tyrosine adsorbed allergoid, Pollinex Parietaria (Bencard Parietaria). Journal of Investigational Allergology and Clinical Immunology 1991;1(1):3744.
  • Boznanski 1996 {published data only}
  • Boznanski A, Willak-Janc E, Domanasiewicz M, Pirogowicz I, Widerska A. Evaluation of soluble components of receptors with weak affinity for IgE (sCD23) in children with pollinosis given specific immunotherapy [Ocena rozpuszczalnej skladowej receptora o slabym powinowactwie dla IgE (sCD23) u dzieci z pylkowica poddanych immunoterapii swoistej]. Pneumonologia i Alergologia Polska 1996;64(7-8):38691.
  • Brown 1964 {published data only}
  • Brown EB, Ipsen J, Popovits C. Use of poisonoak extract in ragweed hay fever. A double-blind study. NY State J Med 1964;64:20503.
  • Bruce 1997 {published data only}
  • Bruce CA, Norman PS, Rosenthal RR, Lichtenstein LM. The role of ragweed pollen in autumnal asthma. Journal of Allergy and Clinical Immunology 1977;59(6):44959.
  • Brunet 1992b {published data only}
  • Brunet C, Bedard P, Lavoie A, Jobin M, Hebert J. Allergic rhinitis to ragweed pollen. II. Modulation of histamine-releasing factor production by specific immunotherapy. Journal of Allergy and Clinical Immunology 1992;89(1 (Pt 1)):8794.
  • Bruno 1986 {published data only}
  • Bruno G, Wuthrich B, Ganderton M, et al.A multicenter trial of immunotherapy with alginate-conjugated grass pollen extract. Annals of Allergy 1986;56(5):38491.
  • Caffarelli 2000 {published data only}
  • Caffarelli C, Sensi LG, Marcucci F, Cavagni G. Preseasonal local allergoic immunotherapy to grass pollen in children: a double-blind, placebo-controlled, randomized trial. Allergy 2000;55:11427.
  • Calderon 2003 {published data only}
  • Calderon M, Durham S, Frew A. Double blind placebo controlled study of specific immunotherapy (SIT) with Alutard SQ grass pollen for seasonal allergic rhinoconjunctivitis. Allergy and Clinical Immunology International 2003;1(Suppl 1): Abstract No. O-14-1.
  • Cantani 1984 {published data only}
  • Cantani A, Businco E, Benincori N, et al.A three year controlled study in children with pollinosis treated with immunotherapy. Annals of Allergy 1984;53(1):7984.
  • Caramia 1996 {published data only}
  • Caramia G, Franceschini F, Cimarelli Z, Ciucchi M, Gagliardini R, Ruffini E. The efficacy of E.P.D., a new immunotherapy, in the treatment of allergic diseases in children. Allergologie et Immunologie Paris 1996;28(9):30810.
  • Charpin 1985 {published data only}
  • Charpin D, Poisson A, Charpin J. The advantages of triple dose histaglobin in the symptomatic treatment of pollinosis. Revue Francaise d'Allergologie et d'Immunologie Clinique 1985;25(2):1035.
  • Chyrek-Borowska 1995 {published data only}
  • Chyrek-Borowska S, Rogalewska A, Szymanski W, Zlotnik I, Michalska I. Efficacy and tolerance of allergenic extracts Allergovit and Novo-Helisen depot in immunotherapy of allergic diseases [Skutecznosc i tolerancja preparatów alergenowych allergovit i novo- helisen depot w immunoterapii chorób alergicznych]. Pneumonologia I Alergologia Polska 1995;63(Suppl 2):3241.
  • Cirla 1996 {published data only}
  • Cirla AM, Sforza N, Roffi GP, Alessandrini A, Stanizzi R, Dorigo N, Sala E, Della Torre F. Preseasonal intranasal immunotherapy in birch-alder allergic rhinitis. Allergy 1996;51:299305.
  • Cockcroft 1977 {published data only}
  • Cockcroft DW, Cuff MT, Tarlo SM, Dolovich J, Hargreave FE. Allergen injection therapy with glutaraldehyde-modified-ragweed pollen-tyrosine adsorbate. Journal of Allergy and Clinical Immunology 1977;60(1):5662.
  • Connell 1967 {published data only}
  • Connell J, Sherman W. Hay fever symptoms related to immunological findings. Annals of Allergy 1967;25(5):23950.
  • Creticos 1996 {published data only}
  • Creticos PS, Reed CE, Norman PS, Khoury J, Adkinson NF, et al.Ragweed immunotherapy in adult asthma. New England Journal of Medicine 1996;334(8):5016.
  • Creticos 2003 {published data only}
  • Creticos P, Lighvani S, Bieneman A, Balcer-Whaley S, Norman P, Lichtenstein L, Schroeder J. Enhanced IL-10 secretion by PBMC during the ragweed season: effect of AIC immunotherapy vs placebo. Journal of Allergy and Clinical Immunology 2003;111(2 (Pt 2)):S201.
  • Crimi 2001 {published data only}
  • Crimi N, et al.A randomised double-blind study of specific immunotherapy (SIT) in patients with seasonal allergic-rhinitis: effects on clinical and inflammatory markers. European Respiratory Journal 2001;18(Suppl 33):482s.
  • D'Amato 1996 {published data only}
  • D'Amato G, Liccardi G, Russo M, Saggese M, D'Amato M. Measurement of serum levels of eosinophil cationic protein to monitor patients with seasonal respiratory allergy induced by Parietaria pollen (treated and untreated with specific immunotherapy).. Allergy 1996;51(4):24550.
  • Demoly 2002 {published data only}
  • Demoly P, Persi L, Dhivert H, Delire M, Bousquet J. Immunotherapy with keyhole lampet hemocyanin-conjugated decapeptide vaccine in cypress pollen allergy. Clinical and Experimental Allergy 2002;32(7):10716.
  • Di Stanislao 1997 {published data only}
  • Di Stanislao C, Di Berardino L, Bianchi I, Bologna G. A double-blind, placebo-controlled study of preventive immunotherapy with E.P.D., in the treatment of seasonal allergic disease. Allergie et Immunologie 1997;30:3942.
  • Dokic 1996 {published data only}
  • Dokic D, Nethe A, Kleine-Tebbe J, Kunkel G, Baumgarten C. Mediator release is altered in immunotherapy-treated patients: a 4-year study. Allergy 1996;51(11):796803.
  • Donat 1981 {published data only}
  • Donat N, Doinel C. Clinical efficacy and changes in specific immunoglobulins after desensitisation to grass pollens over two pollen seasons. Revue Francaise d'Allergologie et d'Immunologie Clinique 1982;22:713.
  • Donovan 1996 {published data only}
  • Donovan JP, Buckeridge DL, Briscoe MP, Clark RH, Day JH. Efficacy of immunotherapy to ragweed antigen tested by controlled antigen exposure. Annals of Allergy, Asthma and Immunology 1996;77:7480.
  • Dorward 1984 {published data only}
  • Dorward A, Waclawski E, Kerr J. A comparison of the clinical and immunological effects of an alum-precipitated five-grass extract with a conjugated two-grass extract in the desensitization of hay fever. Clinical Allergy 1984;14(6):56170.
  • Durham 1991 {published data only}
  • Durham SR, Varney V, Gaga M, Frew AJ, Jacobson M, Kay AB. Immunotherapy and allergic inflammation. Clinical and Experimental Allergy 1991;21 (Suppl 1):20610.
  • Durham 1996 {published data only}
  • Durham S, Ying S, Varney V, Jacobson M, Sudderick R, Mackay I, Kay A, Hamid Q. Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma. Journal of Allergy and Clinical Immunology 1996;97(6):135665.
  • Durham 1999 {published data only}
  • Durham SR, Walker SM, Varga E-M, Jacobson MR, O'Brien F, Noble W, et al.Long-term clinical efficacy of grass-pollen immunotherapy. New England Journal of Medicine 1999;341(7):46875.
  • Durham 1999a {published data only}
  • Durham SR, Varney A, Gaga M, Jacobson MR, Varga EM, Frew AJ, Kay AB. Grass pollen immunotherapy decreases the number of mast cells in the skin. Clinical and Experimental Allergy 1999;29:14906.
  • Dykewicz 1998 {published data only}
  • Dykewicz MS, Fineman S, Skoner DP, Nicklas R, et al.Diagnosis and management of rhinitis: complete guidelines of the Joint Task Force and practice parameters in allergy, asthma and immunology. Annals of Allergy, Asthma and Immunology 1998;81:478518.
  • Egger 1997 {published data only}
  • Egger S, Klimek L. The influence of hypo-sensitisation therapy on the sense of smell in subjects with seasonal allergic rhinitis [Der Einfluss der Hyposensibilisierungstherapie auf das Riechvermogen bei saisonaler Rhinitis allergica.]. Allergologie 1997;20(10):5257.
  • Eng 2006 {published data only}
  • Eng PA, Borer-Reinhold M, Heijnen IA, Gnehm HP. Twelve-year follow-up after discontinuation of preseasonal grass pollen immunotherapy in childhood. Allergy 2006;61:198201.
  • Eriksson 1979 {published data only}
  • Eriksson N, Ahlstedt S, Lovhagen O. Immunotherapy in spring-time hay fever. A clinical and immunological study comparing two different treatment extract compositions. Allergy 1979;34(4):23347.
  • Fal 2002 {published data only}
  • Fal A, Gietkiewicz K, Obojski A, Medrala W, Malolepszy J. The influence of a three-year preseasonal specific immunotherapy on selected parameters of allergic inflammation in pollinosis patients [Wplyw trzyletniej przedsezonowej immunoterapii swoistej na wybrane parametry zapalenia alergicznego u chorych na pylkowice]. Pneumonologia i Alergologia Polska 2002;70(1-2):7886.
  • Fell 1990 {published data only}
  • Fell P, Brostoff J. A single dose desensitization for summer hay fever. Results of a double blind study-1988. European Journal of Clinical Pharmacology 1990;38(1):779.
  • Fontana 1966 {published data only}
  • Fontana V, Holt LJ, Mainland D. Effectiveness of hyposensitization therapy in ragweed hay-fever in children. Journal of the American Medical Association 1966;195(12):98592.
  • Frankland 1954 {published data only}
  • Frankland AW, Augustin R. Prophylaxis of summer hay-fever and asthma. The Lancet 1954;(May 22):10557.
  • Frankland 1963 {published data only}
  • Frankland A, Blair Macaulay D, Gwyn Evans R. Treatment of hay fever by depot injection (shypyrindene) in allergic conditions. Double blind clinical study. Acta Allergologica 1963;18:1756.
  • Franklin 1967 {published data only}
  • Franklin W, Lowell F. Comparison of two dosages of ragweed extract in the treatment of pollinosis. Journal of the American Medical Association 1967;201(12):9157.
  • Frostad 1980 {published data only}
  • Frostad A, Grimmer O, Sandvik L, Aas K. Hyposensitization. Comparing a purified (refined) allergen preparation and a crude aqueous extract from timothy pollen. Allergy 1980;35(2):8195.
  • Frostad 1983 {published data only}
  • Frostad A, Grimmer O, Sandvik L, Moxnes A, Aas K. Clinical effects of hyposensitization using a purified allergen preparation from Timothy pollen as compared to crude aqueous extracts from Timothy pollen and a four-grass pollen mixture respectively. Clinical Allergy 1983;13(4):33757.
  • Furin 1991 {published data only}
  • Furin M, Norman P, Creticos P, Proud D, Kagey-Sobotka A, Lichtenstein L, Naclerio R. Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity. Journal of Allergy and Clinical Immunology 1991;88(1):2732.
  • Gabriel 1977 {published data only}
  • Gabriel M, Ng H, Allan W, Hill L, Nunn A. Study of prolonged hyposensitization with D. pteronyssinus extract in allergic rhinitis. Clinical Allergy 1977;7(4):32539.
  • Galvain 1999 {published data only}
  • Galvain S, Andre C, Vatrinet C, Villet B. Safety and efficacy of liposomes in specific immunotherapy. Current Therapeutic Research, Clinical and Experimental 1999;60(5):27894.
  • Garcia Gonzalez 2002 {published data only}
  • Garcia Gonzalez J, Bartolome Zavala B, Fernandez-Melendez S, Barcelo Munoz J, Miranda Paez A, Carmona Bueno M, et al.Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. Annals of Allergy, Asthma and Immunology 2002;88(5):51822.
  • Garcia-Selles 2003 {published data only}
  • Garcia-Selles J, Pascual A, Funes E, Pagan J, Lopez J, Negro J, Hernandez J. Clinical efficacy and safety of a depigmented and glutaraldehyde polymerized therapeutic vaccine of Parietaria judaica. Allergologia et Immunopathologia 2003;31(2):639.
  • Gehlhar 1998 {published data only}
  • Gehlhar K, Schlaak M, Becker WM, Bufe A. Monitoring allergen immunotherapy of pollen allergic patients: the ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome. Clinical and Experimental Allergy 1999;29:497506.
  • Gietkiewicz 2001 {published data only}
  • Gietkiewicz K, Fal A, Malolepszy J. Evaluation of effectiveness and safety of three year immunotherapy with mixed grass pollen allergens [Ocena skutecznoSci klinicznej i bezpieczenstwa trzyletniej immunoterapii mieszanka alergenow pylkow traw]. Polskie Archiwum Medycyny Wewnetrznej 2001;106(6):11638.
  • Giovannini 2005 {published data only}
  • Giovannini M, Braccioni F, Sella G, Contoli M, Perri G, Frati F, Incorvaia C. Comparison of allergen immunotherapy and drug treatment in seasonal rhinoconjunctivitis: a 3-years study. Allergie et Immunologie 2005;37(2):6971.
  • Girard 1988 {published data only}
  • Girard J, el Habib G, Granjard P. Treatment of hay fever by Allerglobuline: a randomized double-blind study. Clinical Allergy 1988;18(4):393400.
  • Gonzalez 2002 {published data only}
  • Gonzalez P, Florido F, Saenz de San Pedro B, De la Torre F, Rico P, Martin S. Immunotherapy with an extract of Olea europaea quantified in mass units: Evaluation of the safety and efficacy after one year of treatment. Journal of Investigational Allergology and Clinical Immunology 2002;12(4):26371.
  • Goor 1971 {published data only}
  • Goor W, Wuthrich B. Specific therapy of pollinosis. Results of desensitization with two different semi-depot allergen extracts (Allpyral and Suspal) [Zur spezifischen therapie der pollinosis.]. Schweizerische Medizinische Wochenschrift. Journal Suisse de Medecine 1971;101(33):121721.
  • Gordon 1972 {published data only}
  • Gordon V, Caplinger K, Meade JJ, Thompson C. Correlation of type specific fluorescent antibodies to ragweed with symptomatology: double-blind study. Annals of Allergy 1972;30(9):50717.
  • Grammer 1985 {published data only}
  • Grammer L, Shaughnessy M, Shaughnessy J, et al.Allergenicity, immunogenicity, and safety of immunotherapy with various molecular weight ranges of polymerized ragweed. Journal of Allergy and Clinical Immunology 1985;76(21):195200.
  • Guardia 2004 {published data only}
  • Guardia P, Moreno C, Justicia J, Conde J, Cimarra M, Diaz M, Guerra F, Martinez-Cocera C, Gonzalo-Garijo M, Perez-Calderon R, Gonzalez-Quevedo T, Sanchez-Cano M, Vigaray J, Acero S, Blanco R, Martin S, de la Torre F. Tolerance and short-term effect of a cluster schedule with pollen-extracts quantified in mass-units. Allergologia et Immunopathologia 2004;32(5):2717.
  • Haahtela 1984 {published data only}
  • Haahtela T, Wihl J, Munch E, et al.Hyposensitization in hay fever with grass pollen extracts: A three-year study comparing a dialysed alum adsorbed extract with Allpyral®. Annals of Allergy 1984;52(5):35562.
  • Hauser 2003 {published data only}
  • Hauser R, Rice T, Krishna Murthy G, Wand M, Lewis D, Bledsoe T, Paulauskis J. The upper airway response to pollen is enhanced by exposure to combustion particulates: a pilot human experimental challenge study. Environmental Health Perspectives 2003;111(4):4727.
  • Hayashi 1998 {published data only}
  • Hayashi M, Ohashi Y, Tanaka A, Kakinoki Y, Nakai Y. Suppression of seasonal increase in serum interleukin-5 is linked to the clinical efficacy of immunotherapy for seasonal allergic rhinitis. Acta Oto-Laryngologica Supplement 1998;538:13342.
  • Hendrix 1980 {published data only}
  • Hendrix SG, Patterson R, Zeiss R, Pruzansky JJ, Suszko IM, McQueen RC, et al.A multi-institutional trial of polymerised whole ragweed for immunotherapy of ragweed allergy. Journal of Allergy and Clinical Immunology 1980;66(6):48694.
  • Hill 1982 {published data only}
  • Hill DJ, Hosking CS, Shelton MJ, Turner MW. Failure of hyposensitisation in treatment of children with grass-pollen asthma. British Medical Journal 1982;284:3069.
  • Hofman 1997a {published data only}
  • Hofman T. Results of specific immunotherapy with Allergovit in patients with pollen allergy [Wyniki swoistej immunoterapii preparatem Allergovit chorych z alergia pylkowa.]. Polskie Merkuriusz Lekarski 1997;3(16):1836.
  • Hofman 1997b {published data only}
  • Hofman T, Buczylko K, Brewczynski P, Kolasinska B. Evaluation of the efficacy of immunotherapy with allergovit and catalet in patients with hay fever--multidrug evaluations. Pneumonologia i Alergologia Polska 1997;65(1-2):6570.
  • Horak 1980 {published data only}
  • Horak F, Jager S, Skoda-Turk R. Reduced allergen immunotherapy of grass pollinosis (author's transl) [Allergenreduzierte Immuntherapie bei Graserpollinose]. Wiener Klinische Wochenschrift 1980;Suppl 117:368.
  • Ipsen 1988 {published data only}
  • Ipsen H, Schwartz B, Wihl J, Petersen B, Munch E, Janniche H, Lowenstein H. Immunotherapy with partially purified and standardized tree pollen extracts. III. Specific IgE response to the major allergens of alder, birch and hazel pollen during immunotherapy. Allergy 1988;43(5):3707.
  • Ito 1996 {published data only}
  • Ito H, Suzuki M, Mamiya S, Takagi I, Baba S. Study on changes in the level of serum IL-4 and soluble CD 23(s-CD23) with immunotherapy in nasal allergy patients. Acta Otolaryngologica Supplement 1996;525(Suppl):98104.
  • Johansson 1974 {published data only}
  • Johansson S, Miller A, Mullan N, Overell B, Tees E, Wheeler A. Glutaraldehyde-pollen-tyrosine: clinical and immunological studies. Clinical Allergy 1974;4(3):25563.
  • Juniper 1986 {published data only}
  • Juniper E, O'Connor J, Roberts R, Evans S, Hargreave F, Dolovich J. Polyethylene glycol-modified ragweed extract: comparison of two treatment regimens. Journal of Allergy and Clinical Immunology 1986;78(5 (Pt 1)):8516.
  • Kakinoki 2000 {published data only}
  • Kakinoki Y, Ohashi Y, Nakai Y, Tanaka A, Washio Y. Pollen immunotherapy inhibits T helper 1 and 2 cell responses, but suppression of T helper 2 cell response is a more important mechanism related to the clinical efficacy. Archives of Otolaryngology - Head and Neck Surgery 2000;126(1):6370.
  • Karlsson 1986 {published data only}
  • Karlsson R, Agrell B, Dreborg S, Foucard T, Kjellman NIM, Koivikko A, Einarsson R. A double-blind, multicenter immunotherapy trial in children, using a purified and standardized Cladosporium herbarum preparation. Allergy 1986;41:14150.
  • Kasatkin 1976 {published data only}
  • Kasatkin I, Kovtiukh L, Ametov A, Romanenko A. Clinical study of methods for determining immunoglobulin E in allergy. Klinicheskaia Meditsina 1976;54(8):6772.
  • Kemker 1999 {published data only}
  • Kemker BJ, Corey JP, Branca J, Gliklich RE. Development of the allergy outcome survey for allergic rhinitis. Otolaryngology - Head and Neck Surgery 1999;121:6035.
  • Kerr 1963 {published data only}
  • Kerr JW, Murchison LE. A controlled trial of pollen adsorbate in the treatment of hay fever. Scottish Medical Journal 1963;8:4858.
  • Kerr 1964 {published data only}
  • Kerr J. The treatment of hay fever including a controlled trial of the use of alum precipitate pollen adsorbate. Acta Allergologica 1964;19:7677.
  • Keskin 2004 {published data only}
  • Keskin O, Tuncer A, Kalayci O, Adalioglu G, Sekerel B, Sackesen C, Civelek E. The early effects of pre-seasonal grass pollen allergoid immunotherapy on bronchial hyperresponsiveness, symptom-medication scores and ECP levels in children with allergic rhinitis. XXIII Congress of the European Academy of Allergology and Clinical Immunology (EAACI). 2004.
  • Keskin 2005 {published data only}
  • Keskin O, Tuncer A, Yildirim S, Bursali B, Adalioglu G, Sekerel BE. Does specific immunotherapy injection cause an increase in bronchial reactivity?. The Journal of Asthma: Official Journal of the Association for the Care of Asthma 2005;42(9):7658.
  • Kjellman 1980 {published data only}
  • Kjellman N, Lanner A. Hyposensitization in childhood hay fever. A comparison of refined and whole timothy extracts. Allergy 1980;35(4):32334.
  • Kleine-Tebbe 2005 {published data only}
  • Kleine-Tebbe J, Herold D, Ribel M. Clinical safety of a grass pollen allergen tablet for specific immunotherapy. Journal of Allergy and Clinical Immunology 2005;115(2 (Suppl 1)):S266.
  • Kleine-Tebbe 2006 {published data only}
  • Kleine Tebbe J, Ribel M, Herold DA. Safety of a SQ-standardised grass allergen tablet for sublingual immunotherapy: a randomized, placebo-controlled trial. Allergy 2006;61(2):1814.
  • Kleinjans 2004 {published data only}
  • Kleinjans H. Comparison between two SCIT Tree pollen regimens. Pre-seasonal use of a depot allergoid formulation versus full year use of a depot formulation over a 3 year period. XXIII Congress of the European Academy of Allergology and Clinical Immunology (EAACI). 2004.
  • Klimek 1999a {published data only}
  • Klimek L, Dormann D, Jarman ER, Cronwell O, Reichelmann H, Reske-Kunz AB. Short-term preseasonal birch pollen allergoid immunotherapy influences symptoms, specific nasal provocation and cytokine levels in nasal secretions, but not peripheral T-cell responses, in patients with allergic rhinitis. Clinical and Experimental Allergy 1999;29:132635.
  • Klimek 1999b {published data only}
  • Klimek L, Wolf H, Mewes T, Dormann D, Reske Kunz A, Schnitker J, Mann W. The effect of short-term immunotherapy with molecular standardized grass and rye allergens on eosinophil cationic protein and tryptase in nasal secretions. Journal of Allergy and Clinical Immunology 1999;103(1 (Pt 1)):4753.
  • Klimek 2005 {published data only}
  • Klimek L, Mewes T, Wolf H, Hansen I, Schnitker J, Mann W. The effects of short-term immunotherapy using molecular standardized grass and rye allergens compared with symptomatic drug treatment on rhinoconjunctivitis symptoms, skin sensitivity, and specific nasal reactivity. Otolaryngology - Head and Neck Surgery 2005;133(4):53843.
  • Kuhn 1983 {published data only}
  • Kuhn W, Urbanek R, Forster J, Schreyer H, Wais U. Advantages of hyposensitization with a high dose of allergoid in pollen allergy [Vorteile einer Hyposensibilisierung mit hoher dosiertem Allergoid bei Pollenallergie]. Klinische Padiatrie 1983;195(6):4114.
  • Kuhn 1985 {published data only}
  • Kuhn W, Urbanek R, Forster J, et al.Hyposensitization in pollen sensitive children: A 3 year prospective study [Hyposensibilisierung bei pollinosis: dreijahrige prospektive vergleichsuntersuchung bei kindern]. Allergologie 1985;8(3):1039.
  • Lavigne 2002 {published data only}
  • Lavigne F, Desrosiers M, Blacquiere M, Dube N, Vaillancourt P, Tulic M, Eiden J, Hamid Q. Effect of AIC (AmbA 1 immunostimulatory oligonucleotide conjugate) on nasal allergen and inflammatory response to seasonal ragweed exposure [Abstract]. Journal of Allergy and Clinical Immunology 2002;109(1 (Suppl 1)):S205.
  • Leiferman 1975 {published data only}
  • Leiferman K, Yunginger J, Larson J, Gleich G. The effect of immune milk as a treatment for ragweed pollinosis. Annals of Allergy 1975;35(6):36771.
  • Levy 1971 {published data only}
  • Levy D, Lichtenstein L, Goldstein E, Ishizaka K. Immunologic and cellular changes accompanying the therapy of pollen allergy. Journal of Clinical Investigations 1971;50(2):3609.
  • Li 1990 {published data only}
  • Li J, Yunginger J, Reed C, Jaffe H, Nelson D, Gleich G. Lack of suppression of IgE production by recombinant interferon gamma: a controlled trial in patients with allergic rhinitis. Journal of Allergy and Clinical Immunology 1990;85(5):93440.
  • Lichtenstein 1968 {published data only}
  • Lichtenstein L, Norman P, Winkenwerder W. Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever. American Journal of Medicine 1968;44(4):51424.
  • Lichtenstein 1971 {published data only}
  • Lichtenstein L, Norman P, Winkenwerder W. A single year of immunotherapy for ragweed hay fever. Immunologic and clinical studies. Annals of Internal Medicine 1971;75(5):66371.
  • Lichtenstein 1973 {published data only}
  • Lichtenstein L, Ishizaka K, Norman P, Sobotka A, Hill B. IgE antibody measurements in ragweed hay fever. Relationship to clinical severity and the results of immunotherapy. Journal of Clinical Investigations 1973;52(2):47282.
  • Lindsay-Miller 1971 {published data only}
  • Lindsay-Miller A. Pollen Tyrosine in the treatment of hay fever. Clinical Allergy 1971;1(3):351.
  • Lombardi 2001 {published data only}
  • Lombardi C, Gargioni S, Venturi S, Zoccali P, Canonica G, Passalacqua G. Controlled study of preseasonal immunotherapy with grass pollen extract in tablets: Effect on bronchial hyperreactivity. Journal of Investigational Allergology and Clinical Immunology 2001;11(1):415.
  • Lowell 1965 {published data only}
  • Lowell FC, Franklin W. A double-blind study of the effectiveness and specificity of injection therapy in ragweed hay fever. New England Journal of Medicine 1965;273:6759.
  • Machiels 1990 {published data only}
  • Machiels J, Buche M, Somville M, Jacquemin M, Saint Remy J. Complexes of grass pollen allergens and specific antibodies reduce allergic symptoms and inhibit the seasonal increase of IgE antibody. Clinical and Experimental Allergy 1990;20(6):65360.
  • Malling 1999 {published data only}
  • Malling HJ. Allergen specific immunotherapy for asthma. Ugeskr Laeger 2000;162 (4):4779.
  • Manger 1984 {published data only}
  • Manger B, Hess B, Nüsslein H, Krapf F, Schreyer H, Maak G, Baenkler H. Hyposensitization of hay fever patients with Tyrosin-adsorbed grass and rye pollen allergoid. Clinical and immunological parameters during different dosages with TA Tyrosin-Allergoid Gräserpollen [Hyposensibilisierung von Pollinosis-Patienten mit Tyrosin-adsorbiertem Gräser- und Roggenpollenallergoid. Klinische und immunologische Untersuchungen bei verschiedenen Behandlungsschemata mit TA Tyrosin-Allergoid Gräserpollen]. Allergologie 1984;7(6):2228.
  • Martin Munoz 1996 {published data only}
  • Martin Munoz M. Immunotherapy, clinical and bronchial response [Inmunoterapia, respuesta clinica y bronquial.]. Allergologia et Immunopathologia (Madrid) 1996;24(Suppl 1):6879.
  • Mastruzzo 2002 {published data only}
  • Mastruzzo C, Crimi N, Gotti F, Sarva M, Mangano G, Paoline G, Vancheri C, Polposa R. Effect of specific immunotherpy on clinical and inflammatory markers in patients with seasonal allergic rhinitis [Abstract]. Journal of Allergy and Clinical Immunology 2002;109(1 (Suppl 1)):S201.
  • McAllen 1969 {published data only}
  • McAllen M. Hyposensitisation in grass pollen hay fever. Acta Allergol 1969;24:42131.
  • Mewes 1999 {published data only}
  • Mewes T, Klimek L, Mann W, Bollessen M, Wolf H. Short term immune therapy with ALK7 reduces grass-pollen induces rhinoconjunctivitis symptoms and the specific nasal reactivity is more efficient than a symptomatic standard therapy [Kurzzeitimmuntherapie mit ALK7 reduziert die Graspollen-induzierten Rhinokonjunktivitis-Symptome und die spezifische nasale Reaktivitat effizienter als eine symptomatische Standardtherapie]. Allergologie 1999;22(9):581.
  • Miller 1974 {published data only}
  • Miller ACMA, Tees EC. A metabolizable adjuvant: clinical trial of grass pollen-tyrosine adsorbate. Clinical Allergy 1974;4:4955.
  • Miller 1976 {published data only}
  • Miller A. A comparative trial of hyposensitization in 1973 in the treatment of hay fever using Pollinex and Alavac-P. Clinical Allergy 1976;6(6):5516.
  • Mitchell 1971 {published data only}
  • Mitchell W, Davis N, Koenig W, Blank P. Emulsion therapy: a three-year study with ragweed pollinosis. Annals of Allergy 1971;29(11):56472.
  • Moller 1989 {published data only}
  • Moller C. Effect of pollen immunotherapy on food hypersensitivity in children with birch pollinosis. Annals of Allergy 1989;62:3435.
  • Moller 2002 {published data only}
  • Moller C, Dreborg S, Ferdousi HA, Halken S, Host A, Jacobsen L, et al.Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). Journal of Allergy and Clinical Immunology 2002;109:2516.
  • Mosbech 1987 {published data only}
  • Mosbech H, Dreborg S, Madsen F, Ohlsson H, Stahl Skov P, Taudorf E, Weeke B. High dose grass pollen tablets used for hyposensitization in hay fever patients. A one-year double blind placebo-controlled study. Allergy 1987;42(6):4515.
  • Mosbech 1988 {published data only}
  • Mosbech H, Osterballe O. Does the effect of immunotherapy last after termination of treatment? Follow-up study in patients with grass pollen rhinitis. Allergy 1988;43(7):5239.
  • Moss 1987 {published data only}
  • Moss R, Hsu Y, Kwasnicki J, Sullivan M, Reid M. Isotypic and antigenic restriction of the blocking antibody response to ryegrass pollen: correlation of rye group I antigen-specific IgG1 with clinical response. Journal of Allergy and Clinical Immunology 1987;79(2):38798.
  • Moverare 1998 {published data only}
  • Moverare R, Rak S, Elfman L. Allergen-specific increase in interleukin (IL)-4 and IL-5 secretion from peripheral blood mononuclear cells during birch-pollen immunotherapy. Allergy 1998;53(3):27581.
  • Moverare 2000 {published data only}
  • Moverare R, Elfman L, Bjornsson E, Stalenheim G. Changes in cytokine production in vitro during the early phase of birch-pollen immunotherapy. Scandinavian Journal of Immunology 2000;52(2):2006.
  • Muhlethaler 1990 {published data only}
  • Muhlethaler K, Wuthrich B, Peeters A, Terki N, Girard J, Frank E. Hyposensitization in pollinosis. Results of a 3-year controlled study with 2 depot-allergoid grass pollen extracts: aluminum hydroxide-adsorbed allergoid and tyrosine-adsorbed allergoid [Zur Hyposensibilisierung der Pollinose. Ergebnisse einer kontrollierten Studie uber drei Jahre mit zwei Depotallergoid-Graspollenextrakten: Aluminiumhydroxid-adsorbiertes Allergoid (AGD) und Tyrosin-adsorbiertes Allergoid (TA).]. Schweizerische Rundsdchau fur Medizinische Praxis 1990;79(14):4306.
  • Munoz Lejarazu 1993 {published data only}
  • Munoz Lejarazu D, Bernaola G, Fernandez E, Audicana M, Ventas P, Martin S, Fernandez de Corres L. Seasonal versus perennial immunotherapy: evaluation after three years of treatment. Journal of Investigational Allergology and Clinical Immunology 1993;3(4):2106.
  • Naclerio 1997 {published data only}
  • Naclerio RM, Proud D, Moylan B, Balcer S, Freidhoff L, Kagey SA, et al.A double-blind study of the discontinuation of ragweed immunotherapy. Journal of Allergy and Clinical Immunology 1997;100(3):293300.
  • Nakai 2002 {published data only}
  • Nakai Y. Prophylactic immunotherapy for Japanese cedar pollen-sensitive individuals. Practica Otologica 2002;95(2):191201.
  • Nakano 2002 {published data only}
  • Nakano A, Nakano K, Okawa T, Yamakoshi T, Terada N, Numata T, Konno A. The effect of Japanese cedar-specific immunotherapy on cytokine production in peripheral blood mononuclear cells. Acta Otolaryngologica 2002;122(1):5460.
  • Negro 1999 {published data only}
  • Negro J, Wheeler A, Hernandez J, Youlten L, Pascual A, Garcia-Selles F, et al.Comparison of the efficacy and safety of two preseasonal regimens of glutaraldehyde modified, tyrosine-adsorbed parietaria pollen extract over a period of three years in monosensitive patients. Allergologia et Immunopathologia 1999;27:15364.
  • Nelson 1976 {published data only}
  • Nelson H, Brown G, O'Barr T, Branch L, Spaulding H, Black J. Clinical and immunological studies of timothy antigen D immunotherapy. Journal of Allergy and Clinical Immunology 1976;57(5):46372.
  • Niederberger 2004 {published data only}
  • Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth M, Valent P, et al.Vaccination with genetically engineered allergens prevents progression of allergic disease. REFJTL of the National Academy of Sciences of the United States of America 2004;101(2):1467782.
  • Nielsen 1996 {published data only}
  • Nielsen L, Johnsen C, Mosbech H, Poulsen L, Malling H. Antihistamine premedication in specific cluster immunotherapy: a double-blind, placebo-controlled study. Journal of Allergy and Clinical Immunology 1996;97(6):120713.
  • Nolte 1999 {published data only}
  • Nolte H. Allergen extracts, dosing, efficacy and safety of immunotherapy. International Review of Allergology and Clinical Immunology 1999;5 (3):1848.
  • Norman 1968 {published data only}
  • Norman P, Winkenwerder W, Lichtenstein L. Immunotherapy of hay fever with ragweed antigen E: comparisons with whole pollen extract and placebos. Journal of Allergy 1968;42(2):93108.
  • Norman 1969 {published data only}
  • Norman P. A rational approach to desensitization. Journal of Allergy 1969;44(3):12945.
  • Norman 1971 {published data only}
  • Norman P, Winkenwerder W, Lichtenstein L. Maintenance immunotherapy in ragweed hay fever. Booster injections at six week intervals. Journal of Allergy 1971;47(5):27382.
  • Norman 1972 {published data only}
  • Norman PS, Winkenwerder WL, Lichtenstein LM. Trials of alum-precipitated pollen extracts in the treatment of hay fever. Journal of Allergy and Clinical Immunology 1972;50 (1):3144.
  • Norman 1981 {published data only}
  • Norman P, Lichtenstein L, Marsh D. Studies on allergoids from naturally occurring allergens. IV. Efficacy and safety of long-term allergoid treatment of ragweed hay fever. The Journal of Allergy and Clinical Immunology 1981;68(6):46070.
  • Norman 1984 {published data only}
  • Norman P, King T, Alexander JJ, et al.Immunologic responses to conjugates of antigen E in patients with ragweed hay fever. Journal of Allergy and Clinical Immunology 1984;73(6):7829.
  • Norman 1990b {published data only}
  • Norman P, Creticos P, Marsh D. Frequency of booster injections of allergoids. Journal of Allergy and Clinical Immunology 1990;85(1 (Pt 1)):8894.
  • Nouri 2005 {published data only}
  • Nouri A, Pilette C, Jacobson M, Watanabe H, Durham S. IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: effect of immunotherapy. Journal of Allergy and Clinical Immunology 2005;116(1):739.
  • Nouri-Aria 2004a {published data only}
  • Nouri-Aria K, Pilette C, Jacobson M, Wilson D, Durham S. Grass pollen immunotherapy (IT) decreases IL-9 mRNA expressing cells in the nasal mucosa during the pollen season. [Abstract]. Journal of Allergy and Clinical Immunology 2004;113(Suppl 2):S106.
  • Nouri-Aria 2004b {published data only}
  • Nouri-Aria K, Wachholz P, Francis J, Jacobson M, Walker S, Wilcock L, et al.Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. Journal of Immunology 2004;172(5):32529.
  • Nowak-Wegrzyn 2004 {published data only}
  • Nowak-Wegrzyn A, Mofidi S, Ma S, Bardina L, Beyer K. Birch and ragweed pollen immunotherapy in the treatment of pollen-food allergy syndrome [Abstract]. Journal of Allergy and Clinical Immunology 2004;113(Suppl 2):S146.
  • Ohashi 1997 {published data only}
  • Ohashi Y, Nakai Y, Kakinoki Y, Ohno Y, Okamoto H, Sakamoto H, Kato A, Tanaka A. The effect of immunotherapy on the serum levels of eosinophil cationic protein in seasonal allergic rhinitis.. Clinical Otolaryngology and Allied Sciences 1997;22(2):1005.
  • Olsen 1995 {published data only}
  • Olsen O, Frolund L, Heinig J, Jacobsen L, Svendsen U. A double-blind, randomized study investigating the efficacy and specificity of immunotherapy with Artemisia vulgaris or Phleum pratense/betula verrucosa. Allergologia et Immunopathologia (Madrid) 1995;23(2):738.
  • Osterballe 1980 {published data only}
  • Osterballe O. Immunotherapy in hay fever with two major allergens 19,25 and partially purified extract of timothy grass pollen. Allergy 1980;35:47389.
  • Osterballe 1982 {published data only}
  • Osterballe O. Immunotherapy with grass pollen major allergens. Clinical results from a prospective 3-year double blind study. Allergy 1982;37:37988.
  • Osterballe 1982a {published data only}
  • Osterballe O. Nasal and skin sensitivity during immunotherapy with two major allergens 19, 25 and partially purified extract of timothy grass pollen. Allergy 1982;37(3):16977.
  • Osterballe 1982b {published data only}
  • Osterballe O, Egeskjold E, Johansen A, Skov P. Anti-IgG antibodies during immunotherapy with purified grass pollen extracts. Allergy 1982;37(3):20916.
  • Osterballe 1982c {published data only}
  • Osterballe O, Lowenstein H, Norn S, Prahl P, Skov P, Skov P, Weeke B. Immunotherapy with grass pollen major allergens. Immunological results from a prospective 3-year double blind study. Allergy 1982;37(7):491501.
  • Osterballe 1982d {published data only}
  • Osterballe O, Lowenstein H, Prahl P, Skov P, Weeke B. Immunotherapy in hay fever with timothy major allergens. Allergy 1982;37(Suppl 1):89.
  • Osterballe 1982e {published data only}
  • Osterballe O. Side effects during immunotherapy with purified grass pollen extracts. Allergy 1982;37(8):55362.
  • Osterballe 1983 {published data only}
  • Osterballe O, Ipsen H, Weeke B, Lowenstein H. Specific IgE response toward allergenic molecules during perennial hyposensitization: a three-year prospective double-blind study. Journal of Allergy and Clinical Immunology 1983;71(1 (Pt 1)):406.
  • Parr 1976 {published data only}
  • Parr E. Hay fever treated with ACTH gel. Clinical Allergy 1976;6(5):47986.
  • Pastorello 1987 {published data only}
  • Pastorello EA, Incorvaia C, Gerosa A, Vassellatti D, Italia M, Pravettoni V. Allergen specific IgG subclass antibody response in hyposensitization with Dermatophagoides pteronyssinus extract. New England and Regional Allergy REFJTL 1987;8(6):41721.
  • Pastorello 1988 {published data only}
  • Pastorello E, Pravettoni V, Qualizza R, Codecasa L, Incorvaia C. A double blind placebo controlled trial of specific immunotherapy with aluminium hydroxide adsorbed allergoid in grass pollen induced rhinitis. Allergy 1988;43(Suppl 7):48.
  • Pence 1976 {published data only}
  • Pence HL, Mitchell DQ, Greely RL, Updegraff BR, Selfridge HA. Immunotherapy for mountain cedar pollinosis. Journal of Allergy and Clinical Immunology 1976;58:3950.
  • Peng 1992 {published data only}
  • Peng Z, Naclerio R, Norman P, Adkinson NJ. Quantitative IgE- and IgG-subclass responses during and after long-term ragweed immunotherapy. Journal of Allergy and Clinical Immunology 1992;89(2):51929.
  • Pereira 2003 {published data only}
  • Pereira S, Clark T, Darby Y, Salib R, Salagean M, Hewitt L, Powell J, Howarth P, Scadding G. Effects of anti-eotaxin monoclonal antibody CAT-213 on allergen-induced rhinitis. Journal of Allergy and Clinical Immunology 2003;111(2 (Pt 2)):S268.
  • Petersen 1988 {published data only}
  • Petersen BN, Janniche H, Munch EP, Wihl JA, Bowadt H, Ipsen H, Lowenstein H. Immunotherapy with partially purified and standardized tree pollen extracts. Allergy 1988;43:35362.
  • Pilette 2003 {published data only}
  • Pilette C, Nouri-Aria K, Jacobson M, Durham S. Seasonal increases in interleukin-9 expression and in mast cell infiltration of the nasal mucosa in allergic rhinitis are inhibited by grass pollen immunotherapy. XXII Congress of the European Academy of Allergology and Clinical Immunology (EAACI). 2003.
  • Polosa 2003 {published data only}
  • Polosa R, Ligotti F, Mangano G, Mastruzzo C, Pistorio M, Crimi N. Monitoring of seasonal variability in bronchial hyper-responsiveness and sputum cell counts in non-asthmatic subjects with rhinitis and effect of specific immunotherapy. Clinical and Experimental Allergy 2003;33(7):87381.
  • Pronk-Admiraal 2001 {published data only}
  • Pronk-Admiraal C, Schilte P, Bartels P. Effect of immunotherapy on eosinophil activation in pollen sensitive children. Clinical Laboratory 2001;47(5-6):2318.
  • Radcliffe 1996 {published data only}
  • Radcliffe MJ, Lampe FC, Brostoff J. Allergen-specific low-dose immunotherapy in perennial allergic rhinitis: A double-blind placebo-controlled crossoever study. Journal of Investigational Allergology and Clinical Immunology 1996;6:2427.
  • Radcliffe 2003 {published data only}
  • Radcliffe M, Lewith G, Turner R, Prescott P, Church M, Holgate S. Enzyme potentiated desensitisation in the treatment of seasonal allergic rhinitis: double blind randomised controlled study. BMJ 2003;327(7409):2514.
  • Rajakulasingam 1997 {published data only}
  • Rajakulasingam K, Durham S, O'Brien F, Humbert M, Barata L, Reece L, Kay A, Grant J. Enhanced expression of high-affinity IgE receptor (Fc epsilon RI) alpha chain in human allergen-induced rhinitis with co-localization to mast cells, macrophages, eosinophils, and dendritic cells. Journal of Allergy and Clinical Immunology 1997;100(1):7886.
  • Rak 1988 {published data only}
  • Rak S, Lowhagen O, Venge P. The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients. Journal of Allergy and Clinical Immunology 1988;82:47080.
  • Rak 1990 {published data only}
  • Rak S, Hakanson L, Venge P. Immunotherapy abrogates the generation of eosinophil and neutrophil chemotactic activity during pollen season. Journal of Allergy and Clinical Immunology 1990;86(5):70613.
  • Rak 2001 {published data only}
  • Rak S, Heinrich C, Jacobsen L, Scheynius A, Venge P. A double-blinded, comparative study of the effects of short preseason specific immunotherapy and topical steroids in patients with allergic rhinoconjunctivitis and asthma. Journal of Allergy and Clinical Immunology 2001;108:9218.
  • Rasp 1999 {published data only}
  • Rasp G, Klimek L. Short-term immunotherapy-a survey of current studies. Wiener Medizinische Wochenschrift 1999;149(14-15):4039.
  • Ricca 1997 {published data only}
  • Ricca V, Ciprandi G, Pesce G, Riccio A, Varese P, Pecora S, Canonica G. Preseasonal specific immunotherapy with modified Phleum pratense allergenic extracts: tolerability and effects. Allergologia et Immunopathologia (Madrid) 1997;25(4):16775.
  • Roberts 2006 {published data only}
  • Roberts G, Hurley C, Turcanu V, Lack G. Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthma. Journal of Allergy and Clinical Immunology 2006;117:2638.
  • Rogala 2004 {published data only}
  • Rogala B, Jarzab J, Rymarczyk B, Tluczykont B. Allergen specific-IgG4 in circulating immune complexes in patients with inhalant allergy undergoing specific immunotherapy [Wplyw swoistej immunoterapii alergii wziewnej na stezenie IgG4 w krazacych kompleksach immunologicznych]. Wiadomosci lekarskie 2004;57(3-4):12330.
  • Rover 2002 {published data only}
  • Rover A, Reimann S, Zuberbier T, Worm M. Immunophenotypic characterization of peripheral B cells: During short-term immunotherapy with tree pollen allergoid and the immunoadjuvant monophosphoryl lipid A. Journal of Investigational Allergology and Clinical Immunology 2002;12(4):22734.
  • Rozniecka 1995a {published data only}
  • Rozniecka M, Kowalski M, Grzegorczyk J, Wojciechowska B, Sliwinska KM, Rozniecki J. Characteristics of hay fever during pollen season with regard to the influence of specific immunotherapy. I. Clinical course and biochemical changes in nasal lavage] [Przebieg pylkowicy w sezonie pylenia z uwzglednieniem wplywu swoistej immunoterapii. Czesc I: Przebieg kliniczny i zmiany biochemiczne w wydzielinie z nosa]. Pneumonologia i Alergologia Polska 1995;63(3-4):13543.
  • Rozniecka 1995b {published data only}
  • Rozniecka M, Kowalski M, Grzegorczyk J, Wojciechowska B, Sliwinska-Kowalska M, Rozniecki J. The characteristics of pollinosis during the pollen season and the influence of specific immunotherapy. Part II: Cytologic changes and chemotactic activity in nasal lavage [Przebieg pylkowicy w sezonie pylenia z uwzglednieniem wplywu immunoterapii swoistej Czesc II: Zmiany cytologiczne i aktywnosc chemotaktyczna w wydzielinie z nosa]. Pneumonologia i Alergologia Polska 1995;63(3-4):14452.
  • Ruiz 2001 {published data only}
  • Ruiz A, Casanovas M, Gomez MJ, Cimarra M, Martinez-Cocera C, Fernandez-Caldas E, Leti CBF. Safety and efficacy of immunotherapy with a standardized depigmented and glutaraldehyde-polyerized extract of phleum pratense pollen. Journal of Allergy and Clinical Immunology 2001;107(2 (Pt 2)):S260.
  • Sandstrom 2001 {published data only}
  • Sandstrom T, Adelroth E, Rak S, Haahtela T, Aasand G, Rosenhall L, et al.Xolair is effective in the treatment of seasonal birch pollen allergic rhinitis. Annals of Allergy, Asthma and Immunology 2001;86:83.
  • Scordamaglia 1992 {published data only}
  • Scordamaglia A, Passalacqua G, Pisati P, Moscato G, Bertoletti R, Ruffoni S, Canonica G. A multi-allergen ELISA screening method. Comparison with Pharmacia CAP system and Phazet skin prick test. Allergologia et Immunopathologia (Madrid) 1992;20(5):17983.
  • Simon 1990a {published data only}
  • Simon H, Metzner G, Keil E, Forner K, Vogt W, Jager L. Phase-I study of diacetyl-splenopentin (BCH 069). Allergie und Immunologie 1990;36(4):24551.
  • Simon 1990b {published data only}
  • Simon H, Metzner G, Vogt W, Piesch C, Forner K, Schlenvoigt G, Storz H, Haroske D, Jager L. Clinical, biochemical and immunological effectiveness of diacetyl-splenopentin (BCH 069) in hay fever. Allergologia et Immunopathologia (Madrid) 1990;18(3):15560.
  • Simons 2003 {published data only}
  • Simons F, Shikishima Y, van Nest G, Eiden J, HayGlass K. Allergen-selective redirection of immunoregulatory responses in ragweed-allergic humans using dynavax Amb a 1 immunostimulatory oligodeoxyribonucleotide conjugate (AIC). Journal of Allergy and Clinical Immunology 2003;111(2 (Pt 2)):S267.
  • Sin 1996 {published data only}
  • Sin B, Misirhgil Z, Aybay C, Gurbuz L, Imir T. Effect of allergen specific immunotherapy on natural killer cell activitiy, IgE, IFN-g levels and clinical response in patients with allergic rhinitis and asthma. Journal of Investigational Allergology and Clinical Immunology 1996;6:3417.
  • Skoda-Turk 1980 {published data only}
  • Skoda-Turk R, Horak F, Jager S. A modified therapy of hayfever with a depot-preparation (author's transl) [Modifizierte Therapie mit einem Depotpraparat bei Graserpollenallergie.]. Wiener Klinische Wochenschrift. Supplementum 1980;117:246.
  • Sobel 1966 {published data only}
  • Sobel G. Treatment of grass pollenosis with various preparations: eleven-year study. Annals of Allergy 1966;24(9):45968.
  • Soyogul 2005 {published data only}
  • Soyogul G, Bueyuekoeztuerk S, Palanduez S, Rayaman E, Colakoglu B, Cevikbas A. The effects of allergen-specific immunotherapy on polymorphonuclear leukocyte functions in patients with seasonal allergic rhinitis. International Immunopharmacology 2005;5(4):6616.
  • Spiegelman 1967 {published data only}
  • Spiegelman J, Friedman H, Tuft L. Immunologic responses of pollinosis patients treated with alum-precipitated pyridine ragweed extract. Annals of Allergy 1967;25(5):26274.
  • Stuck 2001 {published data only}
  • Stuck B, Schneider-Gene S, Klimek L, Hoermann K. Birch pollen allergoid plus MPL in short-term immunotherapy. Otolaryngology - Head and Neck Surgery 2001;125(2):P199200.
  • Stuck 2004 {published data only}
  • Stuck B, Schneider G, Schaefer D, Klimek L, Hoermann K. Short-term preseasonal immunotherapy with birch pollen allergoid plus monophosphoryllipid A (MPL) - Influence on cytokine production of peripheral T cells in patients with allergic rhinitis. Allergy and Clinical Immunology International 2004;16(2):604.
  • Sykora 2004 {published data only}
  • Sykora T, Tamele L, Zemanova M, Petras M. Efficacy and safety of specific allergen immunotherapy with standardized depod allergen H-AI depot (pollens) [Ucinnost a bezpecnost alergenove imunoterapie se standardizovanymi depotnimi alergeny h-ai depot (pollens)]. Alergie 2004;6(3):1708.
  • Symington 1977 {published data only}
  • Symington I, O'Neill D, Kerr J. Comparision of a glutaraldehyde-modified pollen--tyrosine adsorbate with an alum-precipitated pollen vaccine in the treatment of hay fever.. Clinical Allergy 1977;7(2):18994.
  • Taudorf 1983 {published data only}
  • Taudorf E, Weeke B. Orally administered grass pollen. Allergy 1983;38(8):5614.
  • Te Pas 2004 {published data only}
  • Te Pas E, Hoyte E, McIntire J, Umetsu D. Clinical efficacy of microencapsulated timothy grass pollen extract in grass-allergic individuals. Annals of Allergy, Asthma, and Immunology 2004;92(1):2531.
  • Troise 2000 {published data only}
  • Troise C, Bignardi D, Modena P, Pissacroia C, Di Berardino F. Preventive symptomatic immunotherapy versus placebo in seasonal rhinitis due to grasses in children and to Parietaria in adult patients. Allergie et Immunologie 2000;32(6):2469.
  • Tulic 2004 {published data only}
  • Tulic M, Fiset P, Christodoulopoulos P, Vaillancourt P, Desrosiers M, Lavigne F, Eiden J, Hamid Q. Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response. Journal of Allergy and Clinical Immunology 2004;113(2):23541.
  • Turkeltaub 1990 {published data only}
  • Turkeltaub P, Campbell G, Mosimann J. Comparative safety and efficacy of short ragweed extracts differing in potency and composition in the treatment of fall hay fever. Use of allergenically bioequivalent doses by parallel line bioassay to evaluate comparative safety and efficacy. Allergy 1990;45(7):52846.
  • Vaishnav 2005 {published data only}
  • Vaishnav A, Whaley S, Hamilton R, Levitt D, Creticos P. Evaluation of safety and clinical efficacy of higher dose immunotherapy with AIC (immunostimulatory DNA conjugated with Amb a 1) in patients with ragweed-induced seasonal allergic rhinitis (SAR) [Abstract]. Journal of Allergy and Clinical Immunology 2005;115(2 (Suppl 1)):S65.
  • Valovirta 1999 {published data only}
  • Valovirta E. PAT-the Preventive Allergy Treatment Study design and preliminary results. Wiener Medizinische Wochenschrift 1999;149(14-5):4423.
  • van Adelsberg 2003 {published data only}
  • van Adelsberg J, Philip G, Pedinoff A, Meltzer E, Ratner P, Menten J, Reiss T. Montelukast improves symptoms of seasonal allergic rhinitis over a 4-week treatment period. Allergy 2003;58(12):126876.
  • Van Metre 1980a {published data only}
  • Van Metre TE, Adkinson NF, Lichtenstein LM, Mardiney MR, Norman PS, Rosenberg GL, Sobotka AK, Valentine MD. A controlled study of the effectiveness of the Rinkel method of immunotherapy for ragweed pollen hay fever. Journal of Allergy and Clinical Immunology 1980;65:28897.
  • Van Metre 1980b {published data only}
  • Van Metre TE, Adkinson NF, Amodio FJ, Lichtenstein LM, Mardiney MR, Norman PS, et al.A comparative study of the effectiveness of the Rinkel method and the current standard method of immunotherapy for ragweed pollen hay fever. Journal of Allergy and Clinical Immunology 1980;66:50013.
  • van Metre 1982 {published data only}
  • van Metre TJ, Adkinson NJ, Amodio F, Kagey-Sobotka A, Lichtenstein L, Mardiney MJ, et al.A comparison of immunotherapy schedules for injection treatment of ragweed pollen hay fever. Journal of Allergy and Clinical Immunology 1982;69(2):18193.
  • Vanselow 1966 {published data only}
  • Vanselow N, Kelly J, Meyers M, Johnson A. The effect of 6-mercaptopurine on antibody production in atopic individuals. Journal of Allergy 1966;37:14557.
  • Varney 1992 {published data only}
  • Varney V, Jacobson M, Sudderick R, Robinson D, Irani A, Schwartz L, Mackay I, Kay A, Durham S. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils. American Review of Respiratory Disease 1992;146(1):1706.
  • Varney 1993 {published data only}
  • Varney VA, Hamid QA, Gaga M, Sun Ying M, Jacobson M, Frew AJ, Kay AB, Durham SR. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. Journal of Clinical Investigations 1993;92:64451.
  • Verstraeten 1987 {published data only}
  • Verstraeten J, Verstraeten A. Clinical evaluation of hyposensitization in allergic rhinitis: comparison of the results obtained with three different extracts. Material from a 3-year study. Annals of Allergy 1987;58(6):41620.
  • Vittorio 1996 {published data only}
  • Vittorio R, Giorgio C, Giampaola G, Annamaria R, Paola V, Silvia P, Walter C. Preseasonal specific immunotherapy with modified phleum pratense allergenic extracts: tolerability and effects. Allergologia et Immunopathologia 1996;24(6):25562.
  • Wachholz 2002 {published data only}
  • Wachholz P, Nouri-Aria K, Wilson D, Walker S, Verhoef A, Till S, Durham S. Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology 2002;105(1):5662.
  • Wahn 2003 {published data only}
  • Wahn U, Meltzer E, Finn AJ, Kowalski M, Decosta P, Hedlin G, et al.Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis.[ Erratum appears in J Allergy Clin Immunol. 2003 Jul;112(1):71]. Journal of Allergy and Clinical Immunology 2003;111(4):7639.
  • Walker 1995 {published data only}
  • Walker SM, Varney VA, Gaga M, Jacobson MR, Durham SR. Grass pollen immunotherapy: efficacy and safety during 4-year follow-up study. Allergy 1995;50:40513.
  • Walker 2003 {published data only}
  • Walker S, Jacobson M, Durham S. Grass pollen immunotherapy for two years has sustained effects during two years double-blind placebo-controlled withdrawal of treatment. Journal of Allergy and Clinical Immunology 2003;111(2 (Pt 2)):S267.
  • Watanabe 2003 {published data only}
  • Watanabe H, Nouri-Aria K, Jacobson M, Wilson D, Durham S. Successful grass pollen immunotherapy inhibits eosinophil accumulation in the nasal mucosa: role of adhesion molecules and apoptosis [Abstract]. Allergy and Clinical Immunology International 2003;15(Suppl 1):Abstract No.O-14-2.
  • Weyer 1981a {published data only}
  • Weyer A, Donat N, L'Heritier C, Juilliard F, Pauli G, Soufflet B, David B. Grass pollen hyposensitization versus placebo therapy. I. Clinical effectiveness and methodological aspects of a pre-seasonal course of desensitization with a four-grass pollen extract. Allergy 1981;36(5):30917.
  • Weyer 1981b {published data only}
  • Weyer A, Doinel C, Debbia M, L'Heritier C, Rivat L, Le Mao J, Hirth C, David B. Grass pollen hyposensitization versus placebo therapy. II. Immunotherapy-induced changes in serum IgE and IgG levels. Allergy 1981;36(5):31928.
  • Weyer 1990 {published data only}
  • Weyer A, Guinnepain MT, Sutra JP, Borgnon A, Herpin-Richard N, Ickoviv MR, et al.Seasonal increase of spontaneous histamine release in washed leucocytes from rhinitis patients sensitive to grass pollen. Clinical and Experimental Immunology 1990;79:38591.
  • Wihl 1988 {published data only}
  • Wihl JA, Ipsen H, Petersen BN, Munch EP, Janniche H, Lowenstein H. Immunotherapy with partially purified and standardized tree pollen extracts. Allergy 1988;43:3639.
  • Wilcock 2005 {published data only}
  • Wilcock L, Wachholz P, Na D, Klunker S, Francis J, Larsen J, Durham S. Time-course of Serum IgG4 levels and IgG inhibitory activity following withdrawal of grass pollen immunotherapy (IT). Journal of Allergy and Clinical Immunology 2005;115(2 (Suppl 1)):S265.
  • Williams 2001 {published data only}
  • Williams A, McCarthy K, Howarth P, Stern M, Eccles R, Rajakulasingam K. A study to determine the efficacy of a nasally administered rye grass peptide, Ptl-0901, in the treatment of severe seasonal hayfever. Journal of Allergy and Clinical Immunology 2001;107(2 (Pt 2)):S256.
  • Williams 2002 {published data only}
  • Williams AM, Frank E, Meyer H, Cromwell O, Rajakulasingham RK. Effectiveness of preseasonal allergoid immunotherapy in patients with grass pollen allergy [Abstract]. Allergy 2002;57(s73):51.
  • Wilson 2001a {published data only}
  • Wilson D, Irani A, Walker S, Jacobson M, Mackay I, Schwartz L, Durham S. Grass pollen immunotherapy inhibits seasonal increases in basophils and eosinophils in the nasal epithelium. Clinical and Experimental Allergy 2001;31(11):170513.
  • Wilson 2001b {published data only}
  • Wilson D, Nouri-Aria K, Walker S, Pajno G, O'Brien F, Jacobson M, Mackay I, Durham S. Grass pollen immunotherapy: symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season. Journal of Allergy and Clinical Immunology 2001;107(6):9716.
  • Winther 2000a {published data only}
  • Winther L, Malling H, Moseholm L, Mosbech H. Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. I. Efficacy estimated by a model reducing the bias of annual differences in pollen counts. Allergy 2000;55(9):81826.
  • Winther 2000b {published data only}
  • Winther L, Malling H, Mosbech H. Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. II. Side-effects. Allergy 2000;55(9):82735.
  • Wuthrich 1968 {published data only}
  • Wuthrich B, Storck H. Desensitization results in pollen allergic patients with allpyral and aqueous extracts [Desensibilisierungresulate bei Pollenallergikern mit Allpyral und mit wasserigen Extrakten]. Schweizerische Medizinische Wochenschrift. Journal Suisse de Medecine 1968;98(17):6538.
  • Wuthrich 1977 {published data only}
  • Wuthrich B. Immunotherapy of pollinosis: results of a 2-year study with a new allergen preparation (novo-helisen depot) (author's transl) [Zur spezifischen Hyposensibilisierung der Pollinosis. Ergebnisse einer zweijahrigen Studie mit einem neuen Allergen-Praparat (Novo-Helisen Depot)]. Schweizerische Rundsdchau fur Medizinische Praxis 1977;66(9):2606.
  • Wuthrich 1980 {published data only}
  • Wuthrich B, Hafner G. Pollinosis. II. Specific hyposensitization: indications and results of treatment. A study with the allergen preparation Stallergenes-Depot in the pollen season of 1976, 1977 and 1978 [Pollinosis. II. Spezifische Hyposensibilisierung: Indikation und Behandlungsergebnisse Eine Studie mit dem Allergen-Praparat Stallergenes-Depot in der Pollensaison 1976, 1977 und 1978]. Schweizerische Medizinische Wochenschrift. Journal Suisse de Medecine 1980;110(8):28190.
  • Yariktas 2002 {published data only}
  • Yariktas M, Unlu M, Doner F, Sahin U. Comparison of Leukotriene Receptor Antagonist and Antihistamine Therapy in Seasonal Allergic Rhinitis [Mevsimsel Allerjik Rinitte Lökotrien Reseptör Antagonisti ile Antihistaminik Tedavisinin Karsilastirilmasi]. Turkish Archives of Otolaryngology 2002;40(4):2526.
  • References to studies awaiting assessment
  • Frank 2001 {published data only}
  • Frank E, Williams A, Cromwell O, Atkinson P, Rajakulasingam K. Effectiveness of a pre-seasonal allergoid immunotherapy in patients with seasonal allergic rhinitis due to grass pollen. Journal of Allergy and Clinical Immunology 2001;107(2 (Pt 2)):S260.
  • Szymanski 1996 {published data only}
  • Szymanski W, Rogalewska A, Zlotnik I, Obrzut D, Chyrek-Borowska S. The clinical evaluation of Polish allergen extracts Catalet C and Catalet D in patients with pollinosis. Pneumonologia i Alergologia Polska 1996;64(Suppl 2):2531.
  • References to ongoing studies
  • Rajakulasingam 2006 {published data only}
  • Rajakulasingam, K. Study for evaluation of safety and efficacy of a pre-seasonal immunotherapy with an allergoid preparation of an extract of a 6 grass pollen mixture in pts with a clinically relevant grass pollen sensitivity. National Research Register 2006.
  • Additional references
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  • Bousquet 2001
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