Chronic cough: a natural (and parental) disaster

Authors

  • Lorenzo Moja

    Corresponding author
    1. Italian Cochrane Centre, Mario Negri Institute for Pharmacological Research, Milan, Italy
    • Italian Cochrane Centre, Mario Negri Institute for Pharmacological Research, Milan, Italy.
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Abstract

These are the answers to the Dr Cochrane vignette on pages 1552–1554. How did you get on? Register your score at ebch@wiley.com Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration

Question 1

  • 2.In the medical literature, cough is often defined as chronic after persistence for about four weeks.
  • 3.In non-specific cough, secretions are very limited or non-existent. This cough is classified as ‘dry’.
  • 5.Asthma and non-specific cough are rarely related.

Question 2

  • 2.RR describes the probability of the event in the treatment group compared to the probability in the control group and is interpreted as statistically significant if the 95% CI does not cross one.

Question 3

  • 1.Children receiving antibiotics were significantly less likely to require additional medical treatment (RR:0.15; 95% CI 0.05, 0.49).
  • 4.For every three children treated with antibiotics, one child was cured (95% CI 2.00, 4.00).
  • 5.Children taking antibiotics were significantly more likely than those given placebo to be cured or substantially improved at follow-up (RR 2.42; 95% CI 1.65 to 3.53).

Question 4

  • 5.Very high-dose inhaled corticosteroids are effective but not recommended.

Question 5

  • 4.There was no significant decrease in the frequency of cough (MD − 27.00; 95% CI − 83.07 to 29.07).

Question 6

  • 2.The dose used in the studies included was very high: up to 2 mg/day.
  • 3.High-dose inhaled corticosteroids benefit patients in a time span of two weeks.
  • 4.Very high-dose inhaled corticosteroids may expose children to the risk of adrenal insufficiency.

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