Thymic dependence of amphibian antibody responses
Article first published online: 16 NOV 2005
Copyright © 1974 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 4, Issue 5, pages 343–346, May 1974
How to Cite
Turner, R. J. and Manning, M. J. (1974), Thymic dependence of amphibian antibody responses. Eur. J. Immunol., 4: 343–346. doi: 10.1002/eji.1830040506
- Issue published online: 16 NOV 2005
- Article first published online: 16 NOV 2005
- Manuscript Received: 21 DEC 1973
- Medical Research Council project
Larvae of Xenopus laevis were thymectomized at one week post fertilization and tested as toadlets for their ability to produce circulating antibodies.
Sham-thymectomized animals immunized with human IgG in adjuvant produced both high (IgM) and low molecular weight antibody, while in those immunized with sheep red blood cells, antibody, was detectable only in the IgM moiety. Thymectomized siblings, though apparently healthy, failed to respond to either antigen.
The inhibition of IgM antibody in the amphibian following thymic depletion contrasts with the mammal, where normal or subnormal titers can still be demonstrated. This may point to phylogenetic differences in the role of the thymus. Alternatively, early-thymectomized Xenopus may simply be closer to a completely athymic condition.