R. R. Hardy was a Fellow of the American Cancer Society, California Division.
Peritoneal Ly-1 B cells: Genetic control, autoantibody production, increased lambda light chain expression
Article first published online: 17 NOV 2005
Copyright © 1986 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 16, Issue 4, pages 450–456, 1986
How to Cite
Hayakawa, K., Hardy, R. R. and Herzenberg, L. A. (1986), Peritoneal Ly-1 B cells: Genetic control, autoantibody production, increased lambda light chain expression. Eur. J. Immunol., 16: 450–456. doi: 10.1002/eji.1830160423
- Issue published online: 17 NOV 2005
- Article first published online: 17 NOV 2005
- Manuscript Received: 30 OCT 1985
- NIH. Grant Numbers: GM-17367, HD-01287, CA-04681
Previous studies demonstrate that Ly-1 B cells and their progenitors are clearly detectable in peritoneum in normal mice. In this publication, we show (a) that peritoneal Ly-1 B cells resemble splenic Ly-1 B cells with respect to surface marker expression and functional activity (autoantibody production); (b) that Ly-1 B frequencies in peritoneum are considerably higher than in spleen; and (c) that genetic mechanisms reduce peritoneal Ly-1 B frequencies to minimal levels in SJL-related mice and to below detectability in CBA/N and other mice with the X-linked immunodeficiency (Xid). In addition, we show that that peritoneal (and perhaps splenic) Ly-1 B populations demonstrate an unique bias in immunoglobulin commitment. That is, they are selectively enriched for cells that express IgM heavy chains in association with lambda light chains. Thus, as a whole, evidence presented here defines the peritoneum as a tightly regulated lymphocyte compartment that normally houses a large population of mature Ly-1 B cells with distinctive functional properties.