On secondment from CSIRO Australian Animal Health Laboratory, Geelong, Australia.
Recognition by major histocompatibility complex class I-restricted cytolytic T lymphocytes of cells expressing vaccinia-encoded viral and class I proteins
Article first published online: 17 NOV 2005
Copyright © 1987 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 17, Issue 10, pages 1515–1518, 1987
How to Cite
Andrew, M. E., Coupar, B. E. H., Boyle, D. B. and Blanden, R. V. (1987), Recognition by major histocompatibility complex class I-restricted cytolytic T lymphocytes of cells expressing vaccinia-encoded viral and class I proteins. Eur. J. Immunol., 17: 1515–1518. doi: 10.1002/eji.1830171021
- Issue published online: 17 NOV 2005
- Article first published online: 17 NOV 2005
- Manuscript Received: 21 MAY 1987
- Reserve Bank of Australia, Rural Credits Fund
Target cells expressing influenza virus hemagglutinin (HA) could be recognized by cytotoxic T lymphocytes (CTL) in conjunction with the murine major histocompatibility complex class I antigen, H-2Kd, when both antigens were encoded by recombinant vaccinia virus. This recognition occurred if HA and H-2Kd were encoded by separate vaccinia viruses following dual infection of target cells or if HA and H-2Kd were encoded by a single recombinant virus. In contrast, target cells expressing nucleoprotein (NP) were only recognized by H-2Kd-restricted CTL if both NP and H-2Kd were encoded by the same vaccinia virus. These results show that the requirements for association of H-2Kd with different viral antigens derived from HA or NP can vary. Possible factors contributing to this difference are discussed.