Scholar of the Medical Research Council of Canada.
Avian CD4 and CD8 interact with a cellular tyrosine protein kinase homologous to mammalian p56lck
Article first published online: 17 NOV 2005
Copyright © 1991 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
European Journal of Immunology
Volume 21, Issue 2, pages 397–401, February 1991
How to Cite
Veillette, A. and Ratcliffe, M. J. H. (1991), Avian CD4 and CD8 interact with a cellular tyrosine protein kinase homologous to mammalian p56lck. Eur. J. Immunol., 21: 397–401. doi: 10.1002/eji.1830210222
- Issue published online: 17 NOV 2005
- Article first published online: 17 NOV 2005
- Manuscript Revised: 17 SEP 1990
- Manuscript Received: 1 AUG 1990
- Medical Research Council of Canada
- National Cancer Institute of Canada
- Cancer Research Society Inc.
Functional as well as immunochemical studies have indicated that chicken T lymphocytes express surface antigens homologous to mammalian CD4 and CD8. The results presented in this report demonstrate that the avian CD4 and CD8 homologs are physically associated with a cellular tyrosine protein kinase related to mammalian p56lck. Furthermore, they show that engagement of either avian CD4 or CD8 is associated with a rapid intracellular tyrosine phosphorylation signal, suggesting that the function of these surface molecules may be mediated through alterations of the associated tyrosine protein kinase. Taken together, these findings demonstrate that the associations of CD4 and CD8 with an intracellular tyrosine protein kinase are evolutionarily conserved, further enhancing the likelihood that they are critical for normal immune functions.