Short Paper

The function of human NK cells is enhanced by β-glucan, a ligand of CR3 (CD11b/CD18)

  1. Livia Di Renzo1,*,
  2. Eitan Yefenof2,
  3. Eva Klein1

Article first published online: 13 DEC 2005

DOI: 10.1002/eji.1830210726

Issue

European Journal of Immunology

European Journal of Immunology

Volume 21, Issue 7, pages 1755–1758, July 1991

Additional Information

How to Cite

Di Renzo, L., Yefenof, E. and Klein, E. (1991), The function of human NK cells is enhanced by β-glucan, a ligand of CR3 (CD11b/CD18). Eur. J. Immunol., 21: 1755–1758. doi: 10.1002/eji.1830210726

Author Information

  1. 1

    Department of Tumor Biology, Karolinska Institutet, Stockholm

  2. 2

    The Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah Medical School, Jerusalem

*Department of Tumor Biology, Karolinska Institute, Box 60400, S-10401 Stockholm, Sweden

Publication History

  1. Issue published online: 13 DEC 2005
  2. Article first published online: 13 DEC 2005
  3. Manuscript Revised: 26 MAR 1991
  4. Manuscript Received: 25 JAN 1991

Funded by

  • PHS. Grant Number: 5R01 CA 25250-11

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Abstract

Cells responsible for the natural killer (NK) effect in the human blood can be collected in the low-density lymphocyte subset and the majority of them express CR3. In addition to the iC3b binding site the CR3 molecules possess an epitope which binds β-glucan. Ligands of this site can deliver activation signals to CR3-carrying monocytes and neutrophils. We found that the function of NK cells was also potentiated by preincubation with β-glucan. The treatment increased the proportion of target-binding lymphocytes and of the damaged target cells in the conjugates. The monoclonal antibody OKM-1, directed to the β-glucan-binding site of CR3, abrogated this effect. Another CR3-reactive monoclonal antibody, M522, known to activate monocytes and neutrophils, enhanced the NK function.

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