Article

Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

  1. Raymond G. Goodwin1,*,
  2. Wenie S. Din1,
  3. Terri Davis-Smith1,
  4. Dirk M. Anderson1,
  5. Steven D. Gimpel1,
  6. Timothy A. Sato1,
  7. Charles R. Maliszewski1,
  8. Camilynn I. Brannan2,
  9. Neal G. Copeland2,
  10. Nancy A. Jenkins2,
  11. Terry Farrah2,
  12. Richard J. Armitage1,
  13. William C. Fanslow1,
  14. Craig A. Smith1

Article first published online: 7 DEC 2005

DOI: 10.1002/eji.1830231037

Issue

European Journal of Immunology

European Journal of Immunology

Volume 23, Issue 10, pages 2631–2641, October 1993

Additional Information

How to Cite

Goodwin, R. G., Din, W. S., Davis-Smith, T., Anderson, D. M., Gimpel, S. D., Sato, T. A., Maliszewski, C. R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., Farrah, T., Armitage, R. J., Fanslow, W. C. and Smith, C. A. (1993), Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. European Journal of Immunology, 23: 2631–2641. doi: 10.1002/eji.1830231037

Author Information

  1. 1

    Immunex Research and Development Corporation, NCI-Frederick Cancer Research and Development Center, Frederick

  2. 2

    Seattle and ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick

*Immunex Research and Development Corporation, 51 University Street, Seattle, WA 98101, USA (Fax: 206233-9733)

Publication History

  1. Issue published online: 7 DEC 2005
  2. Article first published online: 7 DEC 2005
  3. Manuscript Accepted: 21 JUL 1993
  4. Manuscript Received: 11 JUN 1993

Funded by

  • National Cancer Institute, Department of Health and Human Services. Grant Number: N01-CO-74101

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Keywords:

  • Murine 4-1BB ligand;
  • Type II protein

Abstract

4-1BB is an inducible T cell antigen that shows sequence homology to members of an emerging family of cytokine receptors, including those for tumor necrosis factor and nerve growth factor. To aid in the analysis of the function of 4-1BB we have utilized a soluble form of the molecule as a probe to identify and clone the gene which encodes its ligand. The ligand for 4-1BB is a type II membrane glycoprotein that has homology to tumor necrosis factor, lymphotoxin, and the ligands for CD40 and CD27, all of which are themselves ligands to receptors in this superfamily. The gene for 4-IBB is on mouse chromosome 4 and maps close to the p80 form of the tumor necrosis factor receptor as well as the gene for CD30. The gene for 4-IBB ligand maps to mouse chromosome 17, but considerably distal to the tumor necrosis factor and lymphotoxin genes. Interaction of 4-1BB with its ligand induces the proliferation of activated thymocytes and splenic T cells, a response which is mimicked on similar cell populations stimulated with an antibody to 4-1BB.

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