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    Smith, C. A., Farrah, T. and Goodwin, R. G., The TNF receptor superfamily of cellular and viralproteins: activation, costimulation and cell death. Cell. 1994. 76: 959962.
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    Grewal, I. S. and Flavell, R. A., A central role of CD40 ligand in the regulation of CD4+ T cell response. Immunol. Today 1996. 17: 410414.
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    DeBenedette, M. A., Shahinian, A., Mak, T. W. and Watts, T. H., Costimulation of CD28 T lymphocytes by 4–1BB ligand. J. Immunol. 1997. 158: 551559.
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    Baum, P. R., Gayle III, R. B., Ramsdell, F., Srinivasan, S., Sorensen, R. A., Watson, M. L., Seldin, M. F., Baker, E., Sutherland, G. R., Clifford, K. N., Alderson, M. R., Goodwin, R. G. and Fanslow, W. C., Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 1994. 13: 39924001.
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    Calderhead, D. M., Buhlmann, J. E., van den Eertwegh, A. J., Claassen, E., Noelle, R. J. and Fell, H. P., Cloning of mouse OX40: a T cell activation marker that may mediate T-B cell interaction. J.Immunol. 1993. 151: 52615271.
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    Ohshima, Y., Tanaka, Y., Tozawa, H., Takahashi, Y., Maliszawski, C. and Delespesse, G., Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 1997. 159: 38383848.
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    Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., Nohara, C., Yagita, H. and Okumura, K., CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 1999. 162: 70587066.
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    Godfrey, W. R., Fagnoni, F. F., Harara, M. A., Buck, D. and Engleman, E. G., Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J. Exp. Med. 1994. 180: 757762.
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    Imura, A., Hori, T., Imada, K., Ishikawa, T., Tanaka, Y., Maeda, M., Imamura, S. and Uchiyama, T., The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J. Exp. Med. 1996. 183: 21852195.
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    Flynn, S., Toellner, K. M., Raykundalia, C., Goodall, M. and Lane, P., CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 1998. 188: 297304.
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    Ohshima, Y., Yang, L. P., Uchiyama, T., Tanaka, Y., Baum, P., Sergerie, M., Hermann, P. and Delespesse, G., OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4+ T cells into high IL-4-producing effectors. Blood. 1998. 92: 33383345.
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    Akiba, H., Miyahira, Y., Atsuta, M., Takeda, K., Nohara, C., Futagawa, T., Matsuda, H., Aoki, T., Yagita, H. and Okumura, H., Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J. Exp. Med. 2000. 191:375380.
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    Nohara, C., Akiba, H., Nakajima, A., Inoue, A., Koh, C. S., Ohshima, H., Yagita, H., Mizuno, Y. and Okumura, K., Ameliorationof experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J. Immunol. 2001. 166: 21082115.
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    Jember, A. G., Zuberi, R., Liu, F. T. and Croft, M., Development ofallergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 2001. 193: 387392.
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    Ohshima, Y., Yang, L. P., Uchiyama, T., Tanaka, Y., Baum, P., Sergerie, M., Hermann, P. and Delespesse, G., OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood. 1998. 92: 33383345.
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    Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L. C., Nose, M., Noda, T. and Sugamura, K., Impairment of antigen-presenting cell function in micelacking expression of OX40 ligand. J. Exp. Med. 2000. 191: 365374.
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    Chen, A. I., McAdam, A. J., Buhlmann, J. E., Scott, S., Lupher, M. L. Jr., Greenfield, E. A., Baum, P. R., Fanslow, W. C., Calderhead, D. M., Freeman, G. J. and Sharpe, A. H., OX40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity. 1999. 11: 689698.
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    Kopf, M., Ruedl, C., Schmitz, N., Gallimore, A., Lefrang, K., Ecabert, B., Odermatt, B. and Bachmann, M. F., OX40-deficient mice are defective in Th cellproliferation but are competent in generating B cell and CTL responses after virus infection. Immunity. 1999. 11: 699708.
  • 31
    Gramaglia, I., Jember, A., Pippig, S. D., Weinberg, A. D., Killeen, N. and Croft, M., The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 2000. 165: 30433050.
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    Rogers, P. R., Song, J., Gramaglia, I., Killeen, N. and Croft, M., OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001. 15: 445455.
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    Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L. C., Nose, M., Noda, T. and Sugamura, K., Impairment of antigen-presenting cell function in micelacking expression of OX40 ligand. J. Exp. Med. 2000. 191: 365374.
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    Takaoka, A., Tanaka, Y., Tsuji, T., Jinushi, T., Hoshino, A., Asakura, Y., Mita, Y., Watanabe, K., Nakaike, S., Togashi, Y., Koda, T., Matsushima, K. and Nishimura, T., A critical role for mouse CXC chemokine(s)in pulmonary neutrophilia during Th type 1-dependent airway inflammation. J. Immunol. 2001. 167: 23492353.