• 1
    Okayama, Y., Kirshenbaum, A. S., and Metcalfe, D. D., Expression of a functional high-affinity IgG receptor, FcγRI, on human mast cells: up-regulation by IFN-γ. J. Immunol. 2000. 164: 43324339.
  • 2
    Razin, E. and Rivera, J., Signal transduction in mast cells and basophils. Springer, New York: 1999.
  • 3
    Jouvin, M. H. E., Adamczewski, M., Numerof, R., Letourneur, O., Valle, A. and Kinet, J. P., Differential control of the tyrosine kinases lyn and syk by the two signalling chains of the high affinity immunoglobulin E receptor. J. Biol. Chem. 1994. 269: 591859225.
  • 4
    Benhamou, M., Ryba, N. J. P., Kihara, H., Nishikata, H. and Siraganian, R. P., Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. J. Biol. Chem. 1993. 268: 2331823324.
  • 5
    Turner, H. and Kinet, J. P., Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 1999. 402: B2430.
  • 6
    Jabril-Cuenod, B., Zhang, C., Scharenberg, A. M., Paolini, R., Numerof, R., Beaven, M. A. and Kinet, J. P., Syk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway throuh SOS and Grb2. J. Biol. Chem. 1996. 271: 1626816272.
  • 7
    Daeron, M., Structural bases of FcγR functions. Intern. Rev. Immunol. 1997. 16: 127.
  • 8
    Kinet, J. P., The high affinity IgE receptor (FcϵRI); From physiology to pathology. Annu. Rev. Immunol. 1999. 17: 931972.
  • 9
    Wang, A. V., Scholl, P. R. and Geha, R. S., Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. J. Exp. Med .1994. 180: 11651170.
  • 10
    Kiefer, F., Brumell, J., Al-Alawi, N., Latour, S., Cheng, A., Veillette, A., Grinstein, S. and Pawson, T., The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils. Mol. Cell. Biol. 1998. 18: 42094220.
  • 11
    Gillooly, D. J., Melendez, A. J., Hockaday, A. R., Harnett, M. M. and Allen, J. M., Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requiresdistinct phosphoinositide 3-kinase activities. Biochem. J. 1999. 344: 605611.
  • 12
    Rose, D. M., Winston, B. W., Chan, E. D., Riches, D. W., Gerwins, P., Johnson, G. L. and Henson, P. M., Fc gamma receptor cross-linking activates p42, p38, and JNK/SAPKmitogen-activated protein kinases in murine macrophages: role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis. J. Immunol. 1997. 158: 34333438.
  • 13
    Edberg, J. C., Yee, A. M., Rakshit, D. S., Chang, D. J., Gokhale, J. A., Indik, Z. K., Schreiber, A. D. and Kimberly, R. P., The cytoplasmicdomain of human FcγRIα alters the functional properties of FcγRI-chain receptor complex. J. Biol. Chem. 1999. 274: 3032830333.
  • 14
    Okayama, Y., Hagaman, D. D. and Metcalfe, D. D., A comparison of mediators releaseor generated by IFN-γ-treated human mast cells following aggregation of FcγRI or FcϵRI. J. Immunol. 2001. 166: 47054712.
  • 15
    Woolhiser, M. R., Okayama, Y., Gilfillan, A. M. and Metcalfe, D. D., IgG-dependent activation of human mast cells following up-regulation of FcγRI by IFN-γ. Eur. J. Immunol. 2001. 31: 32983307.
  • 16
    Beaven, M. A. and Baumgartner, R. A., Downstream signals initiated in mast cells by FcϵRI and other receptors. Curr. Op. Immunol. 1996. 8: 766772.
  • 17
    Yamashita, T., Mao, S. Y. and Metzger, H., Aggregation of the high affinity IgE receptor and enhanced activityof p53/p56lyn protein tyrosine kinase. Proc. Natl. Acad. Sci. USA 1994. 91: 112511255.
  • 18
    Benhamou, M., Stephan, V., Robbins, K. C. and Siraganian, R. P., High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations. J. Biol. Chem. 1992. 267: 73107314.
  • 19
    Eiseman, E. and Bolen, J. B., Engagement of the high affinity IgE receptor activates src protein-related tyrosine kinases. Nature 1992. 355: 7880.
  • 20
    Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A. and Connelly, P. A., Discoveryof a novel, potent, and src family-selective tyrosine kinase inhibitor. J. Biol. Chem. 1996. 271: 695701.
  • 21
    Oliver, J. M., Burg, D. L., Wilson, B. S., McLaughlin, J. L. and Geahlen, R. L., Inhibition of mast cell FcϵRI-mediated signaling and effector function by the syk-selective inhibitor, piceatannol. J. Biol. Chem. 1994. 269: 2969729703.
  • 22
    Suzuki, H., Takei, M., Yanagida, M., Nakahata, T., Kawakami,T. and Fukamachi, H., Early and late events in FcϵRI signal transduction in human cultured mast cells. J. Immunol. 1997. 159: 58815888.
  • 23
    Offermanns, S., Jones, S. V. and Bombien, E., Stimulation of mitogen-activated protein kinase activity by different secretory stimuli in rat basophilic leukemia cells. J. Immunol. 1994. 152: 250261.
  • 24
    Tsai, M., Chen, R. H., Tam, S. Y., Blennis, J. and Galli, S. J., Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or FcϵRI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. Eur. J. Immunol. 1993. 23: 32863291.
  • 25
    Trotta, R., Kanakaraj, P. and Perussia, B., FcgammaR-dependent mitogen-activated protein kinase activation in leukocytes: a common signal transduction event necessary for expression of TNF-alpha and early activation genes. J. Exp. Med. 1996. 184: 10271035.
  • 26
    Melendez, A. J., Gilloly, D. J., Harnett, M. M. and Allen, J. M., Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms. Proc. Natl. Acad. Sci. USA 1998. 95: 21692174.
  • 27
    Kitaura, J., Asai, K., Maeda-Yamamoto, M., Kawakami, Y., Kikkawa, U. and Kawakami, T., Akt-dependent cytokine production in mast cells. J. Exp. Med. 2000. 192: 729740.
  • 28
    Li, H. L., Davis, W. and Pure, E., Suboptimal cross-linking of antigen receptor induces syk-dependent activation of p70S6 kinase through protein kinase C and phosphatidylinositol 3-kinase. J. Biol. Chem 1999. 274: 98129820.
  • 29
    Cissel, D. S., Fraundorfer, P. F. and Beaven, M. A., Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line. J. Pharmacol. Exp. Ther. 1998. 285: 110118.
  • 30
    Barker, S. A., Caldwell, K. K., Hall, A., Martinez, A. M., Pfeiffer, J. R., Oliver, J. M. and Wilson, B. S., Wortmannin blocks lipid and protein kinase activities associated with PI-3 kinase and inhibits a subset of responses induced by FcϵRI cross-linking. Mol. Biol. Cell 1995. 6: 11451158.
  • 31
    Benhamou, M., Bonnerot, C., Fridman, W. H. and Daeron, M., Molecular heterogeneityof murine mast cells Fcγ receptors. J. Immunol. 1990. 144: 30713077.
  • 32
    Latour, S., Fridman, W. H. and Daeron, M., Identification, molecular cloning, biologic properties, and tissue distribution of a novel isoform of murine low-affinity IgG receptor homologous to human FcγRIIB1. J. Immunol. 1996. 157: 189197.
  • 33
    Van de Winkel, J. G. and Anderson, C. L., Biology of human immunoglobulin G Fc receptors. J. Leuk.Biol. 1991. 49: 511524.
  • 34
    Rouard, H., Tamasdan, S., Moncuit, J., Moutel, S., Michon, J., Fridman, W. H. and Teillaud, J. L., Fc receptors as targets for immunotherapy. Intern. Rev. Immunol. 1997. 16: 147185.
  • 35
    Ernst, L. K., Duchemin, A. M. and Anderson, C. L., Association of the high-affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor. Proc. Natl. Acad. Sci. USA 1993. 90: 60236027.
  • 36
    Heijnen, I. A. and Van de Winkel, J. G., Human IgG Fc receptors. Int. Rev. Immunol. 1997. 16: 2955.
  • 37
    Melendez, A., Harnett, M. M. and Allen, J. M., FcgammaRI activation of phospholipase Cgamma1 and protein kinase C in dibutyryl cAMP-differentiated U937 cells is dependent solely on the tyrosine-kinase activated form of phosphatidylinositol-3-kinase. Immunology 1999. 98: 18.
  • 38
    Parravicini, V., Gadina, M., Kovarova, M., Odom, S., Gonzales-Espinosa, C., Furumoto, Y., Saitoh, S., Samelson, L. E., O'Shea, J. J. and Rivera, J., Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol. 2002. 3: 741748.
  • 39
    Lin, S., Cicala, C., Scharenberg, A. M. and Kinet, J. P., The Fc(epsilon)RI beta subunit functions as an amplifier of Fc(epsilon)RI gamma-mediated cell activation signals. Cell 1996. 85: 985995.
  • 40
    Lu-Kuo, J. M., Fruman, D. A., Joyal, D. M., Cantley, L. C. and Katz, H. R., Impaired kit-but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. J. Biol. Chem. 2000. 275: 60226029.
  • 41
    Kawakami, Y., Kitaura, J., Satterthwaite, A. B., Kato, R. M., Asai, K., Hartman, S. E., Maeda-Yamamoto, M., Lowell, C. A., Rawlings, D. J., Witte, O. N. and Kawakami, T., Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J. Immunol. 2000. 165: 12101219.
  • 42
    Tsujimura, T., Kanakura, Y. and Kitamura, Y., Mechanisms of constitutive activation of c-kit receptor tyrosinekinase. Leukemia 1997. 11: 396398.
  • 43
    Hundley, T. R., Prasad, A. R. and Beaven, M. A., Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase. J. Immunol. 2001. 167: 16291636.
  • 44
    Kirshenbaum, A. S., Goff, J. P., Semere, T., Foster, B., Scott, L. M. and Metcalfe, D. D., Demonstration that human mast cells arise from a progenitor cell population that is CD34+, c-kit+ and expresses aminopeptidase N (CD13). Blood 1999. 94: 23332342.
  • 45
    Tkaczyk, C., Metcalfe, D. D. and Gilfillan, A. M., Determination of protein phosphorylation in FcϵRI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditions. J. Immunol. Methods 2002. 268:239243.
  • 46
    Gilfillan, A. M., Kado-Fong, H., Wiggan, G. A., Hakimi, J., Kent, U. and Kochan, J. P., Conservation of signal transduction mechanisms via the human Fc epsilon RI alpha after transfection into a rat mast cell line, RBL 2H3. J. Immunol. 1992. 149: 24452451.
  • 47
    Chaves-Dias, C., Hundley, T. R., Gilfillan, A. M., Kirshenbaum, A. S., Cunha-Melo, J. R., Metcalfe, D. D. and Beaven, M. A., Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines. J. Immunol. 2001. 166: 6646656.