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  • 1
    Meeusen, E. N. and Balic, A., Do eosinophils have a role in the killing of helminth parasites? Parasitol. Today 2000. 16: 95101.
  • 2
    Lee, N. A., Gelfand, E. W. and Lee, J. J., Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? J. Allergy Clin. Immunol. 2001. 107: 945957.
  • 3
    Yousefi, S., Hemmann, S., Weber, M., Hölzer, C., Hartung, K., Blaser, K. and Simon, H.-U., IL-8 is expressed by human peripheral blood eosinophils. Evidence for increased secretion in asthma. J. Immunol. 1995. 154: 54815490.
  • 4
    Schmid-Grendelmeier, P., Altznauer, F., Fischer, B., Bizer, C., Straumann, A., Menz, G., Blaser, K., Wüthrich, B. and Simon, H.-U., Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J. Immunol. 2002. 169: 10211027.
  • 5
    Bochner, B. S., Systemic activation of basophils and eosinophils . J. Allergy Clin. Immunol. 2000. 106: S292–S302.
  • 6
    Riedel, D., Lindemann, A., Brach, M., Mertelsmann, R. and Herrmann, F., Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce surface expression of interleukin-2 receptor p55-chain and CD4 by human eosinophils. Immunol. 1990. 70: 258261.
  • 7
    Taniguchi, T. and Minami, Y., The IL-2/IL-2 receptor system: a current overview. Cell 1993. 75: 58.
  • 8
    Gruss, H. J., Scott, C., Rollins, B. J., Brach, M. A. and Herrmann, F., Human fibroblasts express functional IL-2 receptors formed by the IL-2R α- and β-chain subunit. Association of IL-2 binding with secretion of the monocyte chemoattractant protein-1. J. Immunol. 1996. 157: 851857.
  • 9
    Ciacci, C., Mahida, Y. R., Dignass, A., Koizumi, M. and Podolsky, D. K., Functional interleukin-2 receptors on intestinal epithelial cells. J. Clin. Invest. 1993. 92: 527532.
  • 10
    Espinoza-Delgado, I., Ortaldo, J. R., Winkler-Pickett, R., Sugamura, K., Varesio, L. and Longo, D. L., Expression and role of p75 interleukin-2 receptor on human monocytes. J. Exp. Med. 1990. 171: 18211826.
  • 11
    Pericle, F., Liu, J. H., Diaz, J. I., Blanchard, D. K., Wei,S., Forni, G. and Djeu, J. Y., Interleukin-2 prevention of apoptosis in human neutrophils. Eur. J. Immunol. 1994. 24: 440444.
  • 12
    Rand, T. H., Silberstein, D. S., Kornfeld, H. and Weller, P. F., Human eosinophils express functional interleukin 2 receptors. J. Clin. Invest. 1991. 88: 825832.
  • 13
    Simon, H.-U., Plötz, S. G., Dummer, R. and Blaser, K., Abnormal clones of T cells producing interleukin 5 in idiopathic eosinophilia. N. Engl. J. Med. 1999. 341: 11121120.
  • 14
    Weller, P. F. and Bubley, G. J., The idiopathic hypereosinophilic syndrome. Blood 1994. 83: 27592779.
  • 15
    Oehling, A. G., Akdis, C. A., Schapowal, A., Blaser, K., Schmitz, M. and Simon, H.-U., Suppression of the immune system by oral glucocorticoid therapy in bronchial asthma. Allergy 1997. 52: 144154.
  • 16
    Gratzl, S., Palca, A., Schmitz, M. and Simon, H.-U., Treatment withIFN-α in corticosteroid-unresponsive asthma. J. Allergy Clin. Immunol. 2000. 105: 10351036.
  • 17
    Hamid, Q., Azzawi, M., Ying, S., Moqbel, R., Wardlaw, A. J., Corrigan, C. J., Bradley, B., Durham, S. R., Collins, J. V., Jeffery, P. K., Quint, D. J. and Kay, A. B., Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 1991. 87: 15411546.
  • 18
    Akdis, C. A., Akdis, M., Simon, D., Dibbert, B., Weber, M., Gratzl, S., Kreyden, O., Disch, R., Wüthrich, B., Blaser, K. and Simon, H.-U., T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J. Invest. Dermatol. 1999. 113: 628634.
  • 19
    Simon, H.-U., Weber, M., Becker, E., Zilberman, Y., Blaser, K. and Levi-Schaffer, F., Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. J. Immunol. 2000. 165: 40694075.
  • 20
    Yousefi, S., Hoessli, D. C., Blaser, K., Mills, G. B. and Simon, H.-U., Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J. Exp. Med. 1996. 183: 14071414.
  • 21
    Simon, H.-U., Yousefi, S., Dibbert, B., Levi-Schaffer, F. and Blaser, K., Anti-apoptotic signals of granulocyte-macrophage colony-stimulating factor are transduced via Jak2 tyrosine kinase in eosinophils. Eur. J. Immunol. 1997. 27: 35363539.
  • 22
    Peters, M. S., Schroeter, A. L. and Gleich, G. J., Immunofluorescence identification of eosinophil granule major basic protein in the flame figures of Wells' syndrome. Br. J. Dermatol. 1983. 109: 141148.
  • 23
    Aberer, W., Konrad, K. and Wolff, K., Wells' syndrome is a distinctive entity and not a histologic diagnosis. J. Am. Acad. Dermatol. 1988. 18: 105114.
  • 24
    Dibbert, B., Weber, M., Nikolaizik, W. H., Vogt, P., Schöni,M. H., Blaser, K. and Simon, H.-U., Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation. Proc. Natl. Acad. Sci. USA 1999. 96: 1333013335.
  • 25
    Daigle, I., Yousefi, S., Colonna, M., Green, D. R. and Simon, H.-U., Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat. Med. 2002. 8: 6167.
  • 26
    Hansel, T. T., De Vries, I. J., Iff, T., Rihs, S., Wandzilak, M., Betz, S., Blaser, K. and Walker, C., An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Meth. 1991. 145: 105110.
  • 27
    Simon, H.-U., Yousefi, S., Schranz, C., Schapowal, A., Bachert, C. and Blaser, K., Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J. Immunol. 1997. 158: 39023908.