Article

A role for antibodies in the generation of memory antifungal immunity

  1. Claudia Montagnoli1,
  2. Silvia Bozza1,
  3. Angela Bacci1,
  4. Roberta Gaziano1,
  5. Paolo Mosci1,
  6. Joachim Morschhäuser2,
  7. Lucia Pitzurra1,
  8. Manfred Kopf3,
  9. Jim Cutler4,
  10. Luigina Romani1,*

Article first published online: 7 APR 2003

DOI: 10.1002/eji.200323790

Issue

European Journal of Immunology

European Journal of Immunology

Volume 33, Issue 5, pages 1193–1204, May 2003

Additional Information

How to Cite

Montagnoli, C., Bozza, S., Bacci, A., Gaziano, R., Mosci, P., Morschhäuser, J., Pitzurra, L., Kopf, M., Cutler, J. and Romani, L. (2003), A role for antibodies in the generation of memory antifungal immunity. European Journal of Immunology, 33: 1193–1204. doi: 10.1002/eji.200323790

Author Information

  1. 1

    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

  2. 2

    Zentrum für Infektionsforschung, Universität Würzburg, Würzburg, Germany

  3. 3

    Swiss Federal Institute of Technology Zurich, Zürich-Schlieren, Switzerland

  4. 4

    Research Institute for Children, Children's Hospital, New Orleans, USA

*Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Via del Giochetto, I-06122 Perugia, Italy Fax: +39-075-585-7411

Publication History

  1. Issue published online: 7 APR 2003
  2. Article first published online: 7 APR 2003
  3. Manuscript Accepted: 25 FEB 2003
  4. Manuscript Revised: 10 FEB 2003
  5. Manuscript Received: 24 DEC 2002

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Keywords:

  • B cell;
  • Antibody;
  • Th subset;
  • Regulatory T cell;
  • Fungus

Abstract

Protective immunity to Candida albicans and Aspergillus fumigatus is mediated by antigen-specific Th1 cells. To define the role of B cells and antibodies in the generation ofantifungal immune resistance, B cell-deficient (μMT) mice were assessed for immune resistance to primary and secondary infections with both fungi. The results showed that, although passive administration of antibodies increased the fungal clearance, the innate and Th1-mediated resistance to the primary and secondary infections were both heightened in μMT mice with candidiasis and aspergillosis. However, although capable of efficiently restricting the fungal growth, μMT mice did not survive the re-infection with C. albicans, and this was concurrent with the failure to generate IL-10-producing dendritic cells and regulatory CD4+CD25+ T cells. Antifungal opsonizing antibodies restored IL-10 production by dendritic cells from μMT mice, a finding suggesting that the availability of opsonizing antibodies may condition the nature of the dendritic cell interaction with fungi, possibly impacting on the development of long-lasting antifungal immunity.

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