• 1
    Korb, L. C. and Ahearn, J. M., C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J. Immunol. 1997. 158: 45254528.
  • 2
    Botto, M., Dell'Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P. and Walport, M. J., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 1998. 19: 5659.
  • 3
    Nauta, A. J., Trouw, L. A., Daha, M. R., Tijsma, O., Nieuwland, R., Schwaeble, W. J., Gingras, A. R., Mantovani, A., Hack, E. C. and Roos, A., Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur. J. Immunol. 2002. 32: 17261736.
  • 4
    Fujita, T., Evolution of the lectin-complement pathway and its role in innate immunity. Nat. Rev. Immunol. 2002. 2: 346353.
  • 5
    Garred, P., Madsen, H. O. and Svejgaard, A., Genetics of human mannan-binding protein. In Ezekowitz, R. A. B., Sastry, K. and Reid, K. B. M. (Eds.) Collectins and innate immunity. R. G. Landes Company, Austin 1996, pp 139164.
  • 6
    Koch, A., Melbye, M., Sorensen, P., Homoe, P., Madsen, H. O., Molbak, K., Hansen, C. H., Andersen, L. H., Hahn, G. W. and Garred, P., Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA 2001. 285: 13161321.
  • 7
    Turner, M. W. and Hamvas, R. M. J., Mannose-binding lectin: structure, function, genetics and disease associations. Rev. Immunogenet. 2000. 2: 305322.
  • 8
    Garred, P., Voss, A., Madsen, H. O. and Junker, P., Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients. Genes Immun. 2001. 2: 442450.
  • 9
    Ogden, C. A., deCathelineau, A., Hoffmann, P. R., Bratton, D., Ghebrehiwet, B., Fadok, V. A. and Henson, P. M., C1q and mannose-binding lectin engagement of cell surface calreticulinand CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 2001. 194: 781795.
  • 10
    Herrmann, M., Zoller, O. M., Hagenhofer, M., Voll, R. and Kalden, J. R., What triggers anti-dsDNA antibodies? Mol. Biol. Rep. 1996. 23: 265267.
  • 11
    Herrmann, M., Voll, R. E., Zoller, O. M., Hagenhofer, M., Ponner, B. B. and Kalden, J. R., Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum. 1998. 41: 12411250.
  • 12
    Mevorach, D., Mascarenhas, J. O., Gershov, D. and Elkon, K. B., Complement-dependent clearance of apoptotic cells by human macrophages. J. Exp. Med. 1998. 188: 23132320.
  • 13
    Nauta, A. J., Daha, M. R., Kooten, C. and Roos, A., Recognition andclearance of apoptotic cells: a role for complement and pentraxins. Trends Immunol. 2003. 24: 148154.
  • 14
    Clark, H., Palaniyar, N., Strong, P., Edmondson, J., Hawgood, S. and Reid, K. B., Surfactant protein D reduces alveolar macrophage apoptosis in vivo. J. Immunol. 2002. 169: 28922899.
  • 15
    Pittoni, V. and Valesini, G., The clearance of apoptotic cells: implications for autoimmunity. Autoimmun. Rev. 2002. 1: 154161.
  • 16
    Vandivier, R. W., Ogden, C. A., Fadok, V. A., Hoffmann, P. R., Brown, K. K., Botto, M., Walport, M. J., Fisher, J. H., Henson, P. M. and Greene, K. E., Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J. Immunol. 2002. 169: 39783986.
  • 17
    Garred, P., Pressler, T., Lanng, S., Madsen, H. O., Moser, C., Laursen, I., Balstrup, F., Koch, C. and Koch, C., Mannose-binding lectin (MBL) substitution in an MBL-deficient patient with severe cystic fibrosis. Pediatr. Pulmonol. 2002. 33: 201207.
  • 18
    Tan, S. M., Chung, M. C., Kon, O. L., Thiel, S., Lee, S. H. and Lu, J., Improvements on the purification of mannan-binding lectin and demonstration of its Ca2+-independent association with a C1s-like serine protease. Biochem. J. 1996. 319: 329332.
  • 19
    Roos, A., Bouwman, L. H., Gijlswijk-Janssen, D. J., Faber-Krol, M. C., Stahl, G. L. and Daha, M. R., Human IgA activates the complement system via the mannan-binding lectin pathway. J. Immunol. 2001. 167: 28612868.
  • 20
    Wing, M. G., Seilly, D. J., Bridgman, D. J. and Harrison, R. A., Rapid isolation and biochemical characterization of rat C1 and C1q. Mol. Immunol. 1993. 30: 433440.
  • 21
    Jaffe, E. A., Nachman, R. L., Becker, C. G. and Minick, C. R., Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 1973. 52: 27452756.
  • 22
    Roos, A., Nauta, A. J., Broers, D., Faber-Krol, M. C., Trouw, L. A., Drijfhout, J. W. and Daha, M. R., Specific inhibition of the classical complement pathway by C1q-binding peptides. J. Immunol. 2001. 167: 70527059.
  • 23
    Roos, A., Bouwman, L. H., Munoz, J., Zuiverloon, T., Faber-Krol, M. C., Fallaux-van den Houten FC, Klar-Mohamad, N., Hack, C. E., Tilanus, M. G. and Daha, M. R., Functional characterization of the lectin pathway of complement in human serum. Mol. Immunol. 2003. 39: 655668.
  • 24
    Woltman, A. M., de Fijter, J. W., Kamerling, S. W., Paul, L. C., Daha, M. R. and van Kooten, C., The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. Eur. J. Immunol. 2000. 30: 18071812.