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    Renkvist, N., Castelli, C., Robbins, P. F. and Parmiani, G., A listing of human tumor antigens recognized by T cells. Cancer Immunol. Immunother .2001. 50: 315.
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    Li, P., Morris, D. L., Willcox, B. E, Steinle, A., Spies, T. and Strong, R. K., Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat. Immunol. 2001. 2: 443451.
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    Vivier, E., Tomasello, E. and Paul, P., Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr. Opin. Immunol .2002. 14: 306311.
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    Groh, V., Rhinehart, R., Secrist, H., Bauer, S., Garbstein, K. H. and Spies, T., Broad tumor-associated expression and recognition by tumor-derived γ δ T cells of MICA and MICB. Proc. Natl. Acad. Sci. US 1999. 96: 68796884.
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    Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J.H., Lanier, L. L. and Spies, T., Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999. 285: 727729.
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    Cosman, D., Mulberg, J., Sutherland, C., Chin, W., Armitage, R., Fanslow, W., Kubin, M. and Chalupny, J., ULBP novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001. 14: 123133.
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    Sutherland, C., Chalupny, J., Schooley, K., Vandenbos, T., Kubin, M. and Cosman, D., UL16-binding proteins, novel MHC class I-related protein bind to NKG2D and activate multiple signalling pathways in primary NK cells. J. Immunol .2002. 168: 671679.
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    Pende, D., Cantoni, C., Rivera, P., Vitale, M., Castriconi, R., Marcenaro, S., Nanni, M., Biassoni, R., Bottino, C., Moretta, A. and Moretta, L., Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin. Eur. J. Immunol .2001. 31: 10761086.
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    Vetter, C. S., Groh, V., thor Straten, P., Spies, T., Brocker, E.-B. and Becker, J. C., Expression of stress-induced MHC class I related chain molecules on human melanomas. J. Invest. Dermatol .2002. 118: 600605.
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    Pende, D., Rivera, P., Marcenaro, S., Chang, C.-C., Biassoni, R., Conte, R., Kubin, M., Cosman, D., Ferrone, S., Moretta, L. and Moretta, A., Major histocompatibility complex class I-related chain a and UL16-binding protein expression on tumor cell lines of differenthistotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res. 2002. 62: 61786186.
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    Diefenbach, A. and Raulet, D. H., Strategies for target cell recognition by natural killer cells. Immunol. Rev. 2001. 181: 170184.
  • 12
    Groh, V., Steinle, A., Bauer, S. and Spies, T., Recognition of stress-induced MHC molecules by intestinal epithelial γ δ T cells. Science 1998. 279: 17371740.
  • 13
    Groh, V., Rhinehart, R., Randolph-Habecker, J., Topp, M. S., Riddell, S. R. and Spies, T., Costimulation of CD8α β T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nature 2001. 2: 255260.
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    Wu, J., Groh, V. and Spies, T., T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial γ δ T cells. J. Immunol .2002. 169: 12361240.
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    Diefenbach, A., Jensen, E. R., Jamieson, A. M. and Raulet, D. H. Rae1 and H60 ligands of the NKG2D receptor stimulate tumor immunity. Nature 2001. 412: 165171.
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    Travers, P. J., Arklie, J. L., Trowsdale, J., Patillo, R. A. and Rodmer, W. F., Lack of expression of HLA-ABC antigens in choriocarcinoma and other human tumor cell lines. Natl. Cancer Inst. Monogr. 1982. 60: 175180.
  • 17
    Li, Z., Groh, V., Strong, R. K. and Spies, T., A single amino acid substitution causes loss of expression of a MICA allele. Immunogenetics 2000. 51: 246248.
  • 18
    Welte, S. A., Sinzger, C., Lutz, S. Z., Singh-Jasuja, H., Sampaio, K. L., Eknigk, U., Rammensee, H.-G. and Steinle, A. Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein. Eur. J. Immunol .2003. 33: 194203.
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    Cormier, J. N., Panelli, M. C., Hackett, J. A., Bettinotti, M. P., Mixon, A., Wunderlich, J., Parker, L. L., Restifo, N. P., Ferrone, S. and Marincola, F. M., Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model. Int. J. Cancer .1999. 80: 781790.
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    Algarar, I., Cabrera, T. and Garrido, F., The HLA crossroad in tumor immunology. Hum. Immunol .2000. 61: 6573.
  • 21
    Groh, V., Wu, J., Yee, C. and Spies, T., Tumor-derived soluble MIC ligands impair expression of NKG2D and T cell activation. Nature 2002. 419: 734738.
  • 22
    Giacomini, G., Giorda, E., Fraioli, R., Nicotra, M. R., Vitale, N., Setini, A., Delfino, L., Morabito, A., Benevolo, M., Venturo, I., Mottolese, M., Ferrara, G. B. and Natali P. G., Low prevalence of selective human leukocyte antigen (HLA)-A and HLA-B epitope losses in early-passage tumor cell lines. Cancer Res .1999. 59: 26572667.
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    Park, J. G., Oie, H. K., Sugarbaker, P. H., Henslee, J. G., Chen, T.-R., Johnson, B. E. and Gazdar, A., Characteristics of cell lines established from human colorectal carcinoma. Cancer Res. 1987. 47: 67106718.
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    Lapointe, R., Lemieux, R., Olivier, M. and Darveau, A., Tyrosine kinase and cAMP-dependent protein kinase activities in CD40-activated human B lymphocytes. Eur. J. Immunol. 1996. 26: 23762382.
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    Naviaux, R. K., Costanzi, E., Haas, M. and Verma, I. M., The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J. Virol .1996. 70: 57015705.
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    Boss, J. M., Regulation of transcription of MHC class II genes. Curr. Opin. Immunol .1997. 9: 107113.