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    Thornton, A. M. and Shevach, E. M., CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287296.
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    Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Shimizu, J. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol .1998. 10: 19691980.
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    Hong, S., Wilson, M.T., Serizawa, I., Wu, L., Singh, N., Naidenko, O.V., Miura, T., Haba, T., Scherer, D.C., Wei, J., Kronenberg, M., Koezuka, Y. and Van Kaer, L., The natural killer T cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med .2001. 7: 10521056.
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    Miyamoto, K., Miyake, S. and Yamamura, T., A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001. 413: 531534.
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    Shi, F., Ljunggren, H.-G. and Sarvetnick, N., Innate immunity and autoimmunity: from self-protection to self-destruction. Trends Immunol .2001. 22: 97101.
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    Yang, Y. F., Tomura, M., Ono, S., Hamaoka, T. and Fujiwara, H., Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells. Int. Immunol .2000. 12: 16691675.
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    Hara, M., Kingsley, C. I., Niimi, M., Read, S., Turvey, S. E., Bushell, A. R., Morris, P. J., Powrie, F. and Wood, K., IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol .2001. 166: 37893796.
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    Sanchez-Fueyo, A., Weber, M., Domenig, C., Strom, T. S. and Zheng, X. X., Tracking the immunoregulatory mechanisms active during allograft tolerance. J. Immunol .2002. 68: 22742281.
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    Thorstenson, K. M. and Khoruts, A., Generation of anergic and potentially immunoregulatory CD25+CD4 T cells invivo after the induction of peripheral tolerance with intravenous or oral antigen. J. Immunol .2001. 167: 188195.
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    Baecher-Allan, C., Brown, J. A., Freeman, G. J. and Hafler, D. A., CD4+CD25+high regulatory cells in human peripheral blood. J. Immunol. 2001. 167: 12451253.
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    Jonuleit, H., Schmitt, E., Stassen, M., Tuettenberg, A., Knop, J. and Enk, A. H., Identification and functional characterization of human CD4+CD25+ T cells with regulatory properties isolatedfrom peripheral blood. J. Exp. Med .2001. 193: 12851294.
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    Dieckmann, D., Plottner, H., Berchtold, S., Berger, T. and Schuler, G., Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood. J. Exp. Med .2001. 193: 13031310.
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    Ng, W. F., Duggan, P. J., Ponchel, F., Matarese, G., Lombardi, G., Edwards, A. D., Isaacs, J. D. and Lechler, R. I., Human CD4+CD25+ T cells: a naturally occuring population of regulatory T cells. Blood 2001. 98: 27362744.
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    Chai, J. G., Tsang, J. Y. S., Lechler, R., Simpson, E., Dyson, J. and Scott, D., CD4+CD25+ T cells as immunoregulatory T cells in vitro. Eur. J. Immunol .2002. 32: 23652375.
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    Powrie, F., Carlino, J. O., Leach, M. W., Mauze, S. and Coffman, R. L., A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1 mediated colitis by CD45RBlow CD4+ T cells . J. Exp. Med .1996. 183: 26692674.
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    Kingsley, C. I., Karim, M., Bushell, A. R. and Wood, K. J., CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4 and IL-10 dependent immunoregulation of alloresponses. J. Immunol .2002. 18: 10801086.
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    Dieckmann, D., Bruett, C. H., Ploettner, H., Lutz, M. B. and Schuler, G., Human CD4+CD25+ regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med .2002. 196: 247253.
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    Jonuleit, H., Schmitt, E., Kakirman, H., Stassen, M., Knop, J. and Enk, A. H., Infectious tolerance: human CD25+ regulatory T cells convey suppressor activity to conventional CD4+ T helper cells. J. Exp. Med .2002. 196: 255260.
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    McHugh, R. S., Whitters, M. J., Piccirillo, C. A., Young, D. A., Shevach, E. M., Colins, M. and Byrne, M. C., CD4+CD25+ immunoregulatory T cells, gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002. 16: 311323.
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    Shimizu, J., Yamazaki, S., Takahasi, T., Ishida, Y. and Sakaguchi, S., Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol .2002. 3: 135142.
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    Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic T lymphocytes-associated antigen 4. J. Exp. Med .2000. 192: 303309.
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    Gao, Q., Rouse, T. M., Kazmerzak, K. and Field, E. H., CD4+CD25+ cells regulate CD8 cell anergy in neonatal tolerant mice. Transplantation 1999. 68: 18911897.
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    Piccirillo, C. A. and Shevach, E. M., Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol .2001. 167: 11371140.
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    van Maurik, A., Herber, M., Wood, K. J. and Jones, N. D., Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J.Immunol .2002. 169: 54015404.
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    Murakami, M., Sakamoto, A., Bender, J., Kappler, J. and Marrack, P., CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc. Natl. Acad. Sci. USA 2002. 99: 88328837.
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    Kursar, M., Bonhagen, K., Fensterle, J., Kohler, A., Hurwitz, R., Kamradt, T., Kaufmann, S. H. E. and Mittrücker, H.-W., Regulatory CD4+CD25+ T cells restrict memory CD8+ T cells responses. J. Exp. Med .2002. 196: 15851592.
  • 32
    Bystry, R. S., Aluvihare, V., Welch, K. A., Kallokourdis, M. and Betz, A. G., B cells and professional APC recruit regulatory T cells via CCL4. Nat. Immunol .2001. 2: 11261132.
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    O'Shea, J. J., Ma, A. and Lipsky, P., Cytokines and autoimmunity. Nat. Rev. Immunol. 2002. 2: 3745.
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    Levings, M. K., Sangregorio, R. and Roncarolo, M. G., Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med .2001. 193: 1295302.
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    Pontoux, C., Banz, A. and Papiernik, M., Natural CD4+CD25+ regulatory T cellscontrol the burst of superantigen-induced cytokine production: the role of IL-10. Int. Immunol .2002. 14: 233239.
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    Taylor, P. A., Lees, C. J. and Blazar, B. R., The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002. 99: 34933499.
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    Yamagiwa, S., Gray, J. D., Hashimoto, S. and Horwitz, D. A., A rolefor TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol .2001. 166: 72827289.
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    Cohen, J. L., Trenado, A,. Vasey, D., Klatzmann, D. and Salomon, B. L., CD4+CD25+ immunoregulatory T cells: new therapeutics for graft-versus-host disease. J. Exp. Med .2002. 196: 401406.
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    Jiang, S., Camara, N., Lombardi, G. and Lechler, R. I., Induction of allopeptide-specific human regulatory CD4+CD25+ regulatory T cells ex-vivo. Blood 2003. 102: 21802186.
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    Strehlau, J., Pavlakis, M., Lipman, M., Shapiro, M., Vasconcelos, L., Harmon, W. and Strom, T. B., Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc. Natl. Acad. Sci. USA 1997. 94: 695700.