• 1
    van Crevel, R., Karyadi, E., Preyers, F., Leenders, M., Kullberg, B. J., Nelwan, R. H. and van der Meer, J. W., Increased production of interleukin 4 by CD4+ and CD8+ T cells from patients with tuberculosis is related to the presence of pulmonary cavities. J. Infect. Dis. 2000. 181: 11941197.
  • 2
    Seah, G. T., Scott, G. M. and Rook, G. A., Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis. J. Infect. Dis. 2000. 181: 385389.
  • 3
    Lienhardt, C., Azzurri, A., Amedei, A., Fielding, K., Sillah,J., Sow, O. Y., Bah, B., Benagiano, M., Diallo, A., Manetti, R., Manneh, K., Gustafson, P., Bennett, S., D'Elios, M. M., McAdam, K. P. and Del Prete, G., Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo. Eur. J. Immunol. 2002. 32: 16051613.
  • 4
    Smith, S. M., Klein, M. R., Malin, A. S., Sillah, J., McAdam,K. P. and Dockrell, H. M., Decreased IFN-gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients. Tuberculosis (Edinb.) 2002. 82: 713.
  • 5
    Yong, A. J., Grange, J. M., Tee, R. D., Beck, J. S., Bothamley, G. H., Kemeny, D. M. and Kardjito, T., Total and anti-mycobacterial IgE levels in serum from patients with tuberculosis and leprosy. Tubercle 1989. 70: 273279.
  • 6
    Seah, G. T. and Rook, G. A. W., IL-4 influences apoptosis of Mycobacterium-reactive lymphocytes in the presence of TNF-alpha. J. Immunol. 2001. 167: 12301237.
  • 7
    Umland, S. P., Razac, S., Shah, H., Nahrebne, D. K., Egan, R. W. and Billah, M. M., Interleukin-5 mRNA stability in human T cells is regulated differently than interleukin-2, interleukin-3, interleukin-4, granulocyte/macrophage colony-stimulating factor, and interferon-gamma. Am. J. Respir. Cell Mol. Biol. 1998. 18: 631642.
  • 8
    Butler, N. S., Monick, M. M., Yarovinsky, T. O., Powers, L. S. and Hunninghake, G. W., Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J. Immunol. 2002. 169: 37003709.
  • 9
    Atamas, S. P., Choi, J., Yurovsky, V. V. and White, B., An alternative splice variant of human IL-4, IL-4 delta 2, inhibits IL-4-stimulated T cell proliferation. J. Immunol. 1996. 156: 435441.
  • 10
    Seah, G. T., Gao, P. S., Hopkin, J. and Rook, G. A. W., Interleukin-4 and its alternatively spliced variant (IL-4delta2) in atopic asthmatics. Am. J. Resp. Crit. Care Med. 2001. 164: 10161018.
  • 11
    North, R. J., Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin.Exp. Immunol. 1998. 113: 5558.
  • 12
    Jung, Y. J., LaCourse, R., Ryan, L. and North, R. J., Evidence inconsistent with a negative influence of T helper 2 cells on protection afforded by a dominant T helper 1 response against Mycobacterium tuberculosis lung infection in mice. Infect. Immun. 2002. 70: 64366443.
  • 13
    Hernandez-Pando, R., Orozco, H., Sampieri, A., Pavón, L., Velasquillo, C., Larriva-Sahd, J., Alcocer, J. M. and Madrid, M. V., Correlation between the kinetics of Th1/Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis. Immunology 1996. 89: 2633.
  • 14
    Hernandez-Pando, R., Pavon, L., Arriaga, K., Orozco, H., Madrid-Marina, V. and Rook, G. A. W., Pathogenesis of tuberculosis in mice exposed to low and high doses of an environmental mycobacterial saprophyte. Infect. Immun. 1997. 65: 33173327.
  • 15
    Lindblad, E. B., Elhay, M. J., Silva, R., Appelberg, R. and Andersen, P., Adjuvant modulation of immune responses to tuberculosis subunit vaccines. Infect. Immun. 1997. 65: 623629.
  • 16
    Wangoo, A., Sparer, T., Brown, I. N., Snewin, V. A., Janssen, R., Thole, J., Cook, H. T., Shaw, R. J. and Young, D. B., Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease. J. Immunol. 2001. 166: 34323439.
  • 17
    Tramontana, J. M., Utaipat, U., Molloy, A., Akarasewi, P., Burroughs, M., Makonkawkeyoon, S., Johnson, B., Klausner, J. D., Rom, W. and Kaplan, G., Thalidomide treatment reduces tumor necrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis. Mol. Med. 1995. 1: 384397.
  • 18
    Moreira, A. L., Sampaio, E. P., Zmuidzinas, A., Frindt, P., Smith, K. A. and Kaplan, G., Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J. Exp. Med. 1993. 177: 16751680.
  • 19
    Moreira, A. L., Tsenova, L., Aman, M. H., Bekker, L. G., Freeman, S., Mangaliso, B., Schroder, U., Jagirdar, J., Rom, W. N., Tovey, M. G., Freedman, V. H. and Kaplan, G., Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice. Infect. Immun. 2002. 70: 21002107.
  • 20
    Hernandez-Pando, R. and Rook, G. A. W., The role of TNF-alpha in T cell-mediated inflammation depends on the Th1/Th2 cytokine balance. Immunology 1994. 82: 591595.
  • 21
    Al Attiyah, R., Rosen, H. and Rook, G. A. W., A model for the investigation of factors influencing haemorrhagic necrosis mediated by tumour necrosis factor in tissue sites primed with mycobacterial antigen preparations. Clin. Exp. Immunol. 1992. 88: 537542.
  • 22
    Wynn, T. A., Cheever, A. W., Jankovic, D., Poindexter, R. W., Caspar, P., Lewis, F. A. and Sher, A., An IL-12-based vaccination method for preventing fibrosis induced by schistosomeinfection. Nature 1995. 376: 594596.
  • 23
    Lawrence, C. E., Paterson, J. C., Higgins, L. M., MacDonald, T. T., Kennedy, M. W. and Garside, P., IL-4-regulated enteropathy in an intestinal nematode infection. Eur. J. Immunol. 1998. 28: 26722684.
  • 24
    Ferluga, J., Doenhoff, M. J. and Allison, A. C., Increased hepatotoxicity of bacterial lipopolysaccharide in mice infected with Schistosoma mansoni. Parasite Immunol. 1979. 1: 289294.
  • 25
    Lee, C. G., Homer, R. J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J. M., Gotwals, P., Noble, P., Chen, Q., Senior, R. M. and Elias, J. A., Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J. Exp. Med. 2001. 194: 809821.
  • 26
    Kodera, T., McGaha, T. L., Phelps, R., Paul, W. E. and Bona,C. A., Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts. Proc. Natl. Acad. Sci. USA 2002. 99: 38003805.
  • 27
    Sempowski, G. D., Derdak, S. and Phipps, R. P., Interleukin-4 and interferon-gamma discordantlyregulate collagen biosynthesis by functionally distinct lung fibroblast subsets. J. Cell. Physiol. 1996. 167: 290296.
  • 28
    Atamas, S. P., Yurovsky, V. V., Wise, R., Wigley, F. M., Goter Robinson, C. J., Henry, P., Alms, W. J. and White, B., Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis Rheum. 1999. 42: 11681179.
  • 29
    Seah, G. T. and Rook, G. A. W., High levels of mRNA encoding IL-4 in unstimulated peripheral blood mononuclear cells from tuberculosis patients revealed by quantitative nested RT-PCR; correlations with serum IgE levels. Scand. J. Infect. Dis. 2000. 33: 106109.
  • 30
    Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schreiber, R., Mak, T. W. and Bloom, B. R., Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity. 1995. 2: 561572.
  • 31
    Keane, J., Gershon, S., Wise, R. P., Mirabile-Levens, E., Kasznica, J., Schwieterman, W. D., Siegel, J. N. and Braun, M. M., Tuberculosis associated withinfliximab, a tumor necrosis factor alpha-neutralizing agent. N. Engl. J. Med. 2001. 345: 10981104.
  • 32
    Klausner, J. D., Makonkawkeyoon, S., Akarasewi, P., Nakata, K., Kasinrerk, W., Corral, L., Dewar, R. L., Lane, H. C., Freedman, V. H. and Kaplan, G., The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 and M. tuberculosis infection. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1996. 11: 247257.
  • 33
    Sampaio, E. P., Sarno, E. N., Galilly, R., Cohn, Z. A. and Kaplan, G., Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J. Exp. Med. 1991. 173: 699703.
  • 34
    Kam, J. C., Szefler, S. J., Surs, W., Sher, E. R. and Leung,D. Y., Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J. Immunol. 1993. 151: 34603466.
  • 35
    Iademarco, M. F., Barks, J. L. and Dean, D. C., Regulation of vascular cell adhesion molecule-1expression by IL-4 and TNF-alpha in cultured endothelial cells. J. Clin. Invest. 1995. 95: 264271.
  • 36
    Hernandez-Pando, R., Orozco, H., Arriaga, K., Sampieri, A., Larriva, S. J. and Madrid, M. V., Analysis of the local kinetics and localisation of interleukin-1 alpha, tumour necrosis factor-alpha and transforming growth factor-beta during the course of experimental pulmonary tuberculosis. Immunology 1997. 90: 507516.
  • 37
    Jarnagin, J. L. and Luchsinger, D. W., The use of fluorescein diacetate and ethidium bromide as a stain for evaluating viability of mycobacteria. Stain Technol. 1980. 55: 253258.
  • 38
    Finkelman, F. D., Madden, K. B., Morris, S. C., Holmes, J. M., Boiani, N., Katona, I. M. and Maliszewski, C. R., Anti-cytokine antibodies as carrier proteins. Prolongation of invivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol. 1993. 151: 12351244.
  • 39
    Pietch, J. L., Ehlers, S. and Jacobs, E., Cytokine gene expression in the lung of BALB/c mice during primary and secondary intranasal infection with Mycoplasma pneumoniae. Microbiology 1994. 14: 20432047.
  • 40
    Woessner, J. F., The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid. Arch. Biochem. Biophys. 1961. 93: 440447.
  • 41
    Woessner, J. F., Jr., Total, latent and active collagenase during the course of post-partum involution of the rat uterus. Effect of oestradiol. Biochem. J. 1979. 180: 95102.