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  • 1
    Nitschke, L., Carsetti, R., Ocker, B., Köhler, G. and Lamers,M. C., CD22 is a negative regulator of B cell receptor signaling. Curr. Biol. 1997. 7: 133143.
  • 2
    O'Keefe, T. L., Williams, G. T., Davies, S. L. and Neuberger, M. S., Hyperresponsive B cells in CD22-deficient mice. Science 1996. 274: 798801.
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    Otipoby, K. L., Andersson, K. B., Draves, K. E., Klaus, S. J., Farr, A. G., Kerner, J. D., Perlmutter, R. M., Law, C. L. and Clark, E. A., CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 1996. 384: 634637.
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    Sato, S., Miller, A. S., Inaoki, M., Bock, C. B., Jansen, P. J., Tang, M. L. and Tedder, T. F., CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signaltransduction: altered signaling in CD22-deficient mice. Immunity 1996. 5: 551562.
  • 5
    Chan, V. W., Lowell, C. A. and DeFranco, A. L., Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr. Biol. 1998. 8: 545553.
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    Smith, K. G. C., Tarlinton, D. M., Doody, G. M., Hibbs, M. L. and Fearon, D. T., Inhibition of the B cell by CD22: a requirement for Lyn. J. Exp. Med. 1998. 187: 807811.
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    Doody, G. M., Justement, L. B., Delibrias, C. C., Matthews, R. J., Lin, J., Thomas, M. L. and Fearon, D. T., A role in B cell activation for CD22 and the protein tyrosine phosphataseSHP. Science 1995. 269: 242244.
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    Cyster, J. G. and Goodnow, C. C., Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 1995. 2: 1324
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    Cyster, J. G. and Goodnow, C. C., Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity 1997. 6: 509517.
  • 10
    Wakabayashi, C., Adachi, T., Wienands, J. and Tsubata, T., A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science 2002. 298: 23922395.
  • 11
    Sato, S., Jansen, P. J. and Tedder, T. F., CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc. Natl. Acad. Sci. USA 1997. 94: 1315813162.
  • 12
    Otipoby, K. L., Draves, K. E. and Clark, E. A., CD22 regulates B cell receptor-mediated signalsvia two domains that independently recruit Grb2 and SHP-1. J. Biol. Chem. 2001. 276: 4431544322.
  • 13
    Law, C. L., Sidorenko, S. P., Chandran, K. A., Zhao, Z., Shen, S. H., Fischer, E. H. and Clark, E. A., CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. J. Exp. Med. 1996. 183: 547560.
  • 14
    Poe, J. C., Fujimoto, M., Jansen, P. J., Miller, A. S. and Tedder, T. F., CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. J. Biol. Chem. 2000. 275: 1742017427.
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    Yohannan, J., Wienands, J., Coggeshall, K. M. and Justement, L. B., Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. J. Biol. Chem. 1999. 274: 1876918776.
  • 16
    Ono, M., Bolland, S., Tempst, P. and Ravetch, J. V., Role of the inositol phosphatase ship in negative regulation of the immune system by the receptor Fc-gamma-RIIb. Nature 1996. 383: 263266.
  • 17
    Brauweiler, A., Tamir, I., Dal Porto, J., Benschop, R. J., Helgason, C. D., Humphries, R. K., Freed, J. H. and Cambier, J. C., Differential regulation ofB cell development, activation, and death by the src homology 2 domain-containing 5′ inositol phosphatase (SHIP). J. Exp. Med. 2000. 191: 15451554.
  • 18
    Samardzic, T., Marinkovic, D., Danzer, C. P., Gerlach, J., Nitschke, L. and Wirth, T., Reduction of marginal zone B cells in CD22-deficient mice. Eur. J. Immunol. 2002. 32: 561567.
  • 19
    Nitschke, L., Floyd, H., Ferguson, D. J. and Crocker, P. R., Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B cells. J. Exp. Med. 1999. 189: 15131518.
  • 20
    Lajaunias, F., Nitschke, L., Moll, T., Martinez-Soria, E., Semac, I., Chicheportiche, Y., Parkhouse, R. M. and Izui, S., Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes. J. Immunol. 2002. 168: 60786083.
  • 21
    Crocker, P. R. and Varki, A., Siglecs, sialic acids and innate immunity. Trends Immunol. 2001. 22: 337342.
  • 22
    Kelm, S., Gerlach, J., Brossmer, R., Danzer, C. P. and Nitschke, L., The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound. J. Exp. Med. 2002. 195: 12071213.
  • 23
    Jin, L., McLean, P. A., Neel, B. G. and Wortis, H. H., Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling. J. Exp. Med. 2002. 195: 11991205.
  • 24
    Wienands, J., Schweikert, J., Wollscheid, B., Jumaa, H., Nielsen, P. J. and Reth, M., SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J. Exp. Med. 1998. 188: 791795.
  • 25
    Fu, C., Turck, C. W., Kurosaki, T. and Chan, A. C., BLNK: a centrallinker protein in B cell activation. Immunity 1998. 9: 93103.
  • 26
    Hayashi, K., Nittono, R., Okamoto, N., Tsuji, S., Hara, Y., Goitsuka, R. and Kitamura, D., The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells. Proc. Natl. Acad. Sci. USA 2000. 97: 27552760.
  • 27
    Jumaa, H., Wollscheid, B., Mitterer, M., Wienands, J., Reth,M. and Nielsen, P. J., Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 1999. 11: 547554.
  • 28
    Pappu, R., Cheng, A. M., Li, B., Gong, Q., Chiu, C., Griffin, N., White, M., Sleckman, B. P. and Chan, A. C., Requirement forB cell linker protein (BLNK) in B cell development. Science 1999. 286: 19491954.
  • 29
    Ishiai, M., Kurosaki, M., Pappu, R., Okawa, K., Ronko, I., Fu, C., Shibata, M., Iwamatsu, A., Chan, A. C. and Kurosaki, T., BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity 1999. 10: 117125.
  • 30
    Flemming, A., Brummer, T., Reth, M. and Jumaa, H., The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat. Immunol. 2003. 4: 3843.
  • 31
    Jumaa, H., Bossaller, L., Portugal, K., Storch, B., Lotz, M., Flemming, A., Schrappe, M., Postila, V., Riikonen, P., Pelkonen, J., Niemeyer, C. M. and Reth, M., Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Nature 2003. 423: 452456.
  • 32
    Blasioli, J., Paust, S. and Thomas, M. L., Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22. J. Biol. Chem. 1999. 274: 23032307.
  • 33
    Leprince, C., Draves, K. E., Geahlen, R. L., Ledbetter, J. A. and Clark, E. A., CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc. Natl. Acad. Sci. USA 1993. 90: 32363240.
  • 34
    Peaker, C. J. and Neuberger, M. S., Association of CD22 with the B cell antigen receptor. Eur. J. Immunol. 1993. 23: 13581363.
  • 35
    Fujimoto, M., Bradney, A. P., Poe, J. C., Steeber, D. A. and Tedder, T. F., Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop. Immunity 1999. 11: 191200.
  • 36
    Tedford, K., Nitschke, L., Girkontaite, I., Charlesworth, A., Chan, G., Sakk, V., Barbacid, M. and Fischer, K. D., Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nat. Immunol. 2001. 2: 548555.
  • 37
    Chiu, C. W., Dalton, M., Ishiai, M., Kurosaki, T. and Chan, A. C., BLNK: molecular scaffolding through ‘cis’-mediated organization of signaling proteins. EMBO J. 2002. 21: 64616472.
  • 38
    Mizuno, K., Tagawa, Y., Mitomo, K., Arimura, Y., Hatano, N., Katagiri, T., Ogimoto, M. and Yakura, H., Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells. J. Immunol. 2000. 165: 13441351.
  • 39
    Mizuno, K., Tagawa, Y., Mitomo, K., Watanabe, N., Katagiri, T., Ogimoto, M. and Yakura, H., Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase. J. Immunol. 2002. 169: 778786.
  • 40
    Doody, G. M., Bell, S. E., Vigorito, E., Clayton, E., McAdam, S., Tooze, R., Fernandez, C., Lee, I. J. and Turner, M., Signaltransduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat. Immunol. 2001. 2: 542547.
  • 41
    Engels, N., Wollscheid, B. and Wienands, J., Association of SLP-65/BLNK with the B cell antigenreceptor through a non-ITAM tyrosine of Ig-alpha. Eur. J. Immunol. 2001. 31: 21262134.
  • 42
    Kabak, S., Skaggs, B. J., Gold, M. R., Affolter, M., West, K. L., Foster, M. S., Siemasko, K., Chan, A. C., Aebersold, R. and Clark, M. R., The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol. Cell Biol. 2002. 22: 25242535.
  • 43
    Stoddart, A., Ray, R. J. and Paige, C. J., Analysis of murine CD22 during B cell development: CD22 is expressed on B cell progenitors prior to IgM. Int. Immunol. 1997. 9: 15711579.
  • 44
    Niiro, H. and Clark, E. A., Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2002. 2: 945956.
  • 45
    Samardzic, T., Gerlach, J., Muller, K., Marinkovic, D., Hess, J., Nitschke, L. and Wirth, T., CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Eur.J. Immunol. 2002. 32: 24812489.
  • 46
    Cariappa, A., Tang, M., Parng, C., Nebelitskiy, E., Carroll,M., Georgopoulos, K. and Pillai, S., The follicular versus marginal zone B lymphocyte cell fate decision is regulated byAiolos, Btk, and CD21. Immunity 2001. 14: 603615.