• 1
    Savage, D. C., Mucosal microbiota. In Ogra, P. L., Mestecky, J., Lamm, M. E, Strober, W., Bienenstock, J. and McGhee, J. R. (Eds.) Mucosal immunology. Academic Press, San Diego 1999, p 19.
  • 2
    MacDonald, T. T., Monteleone, G. and Pender, S. L. F., Recent developments in the immunology of inflammatory bowel disease. Scand. J. Immunol. 2000. 51: 29.
  • 3
    Strober, W., Fuss, I. J. and Blumberg, R. S., The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 2002. 20: 495549.
  • 4
    Groux, H. and Powrie, F., Regulatory T cells and inflammatory bowel disease. Immunol. Today 1999.20: 442445.
  • 5
    Powrie, F., Carlino J., Leach, M. W., Mauze, S. and Coffman, R. L., A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB-low CD4+ T cells . J. Exp. Med. 1996. 183: 26692674.
  • 6
    Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L. and Powrie, F., An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 1999. 190: 9951004.
  • 7
    Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J. E. and Roncarolo, M. G., A CD4+ T cell subset inhibits antigen-specific T cell responses and prevents colitis . Nature 1997. 389: 737742.
  • 8
    Strober, W., Kelsall, B. L., Fuss, I., Marth, T., Ludviksson,B., Ehrhardt, R. and Neurath, M., Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol. Today 1997. 18: 6164.
  • 9
    Garside, P., Mowat, A. M. and Khoruts, A., Oral tolerance in disease. Gut 1999. 44: 137142.
  • 10
    Brimnes, J., Reimann, J. M., Nissen, H. and Claesson, M. H., Enteric bacterial antigens activate CD4+ T cells from scid mice with inflammatory bowel disease. Eur. J. Immunol. 2001. 31: 2331.
  • 11
    Gad, M., Brimnes, J. and Claesson, M. H., CD4+ T regulatory cells from the colonic lamina propria of normal mice inhibit proliferation of enterobacteria-reactive, disease inducing Th1-cells from scid mice with colitis. Exp. Clin. Immunol .2003. 131: 3440.
  • 12
    Thornton, A. M. and Shevach, E. M., CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin-2 production . J. Exp. Med. 1998. 188: 287296.
  • 13
    Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 19691980.
  • 14
    Takahashi, T., Tagami, T., Yamazaki, Y., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic lymphocyte-associated antigen 4. J. Exp. Med. 2000. 192: 303310.
  • 15
    Roncarolo, M. G. and Levings, M. K., The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 2000. 12: 676683.
  • 16
    Shevach, E. M., CD4+CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002. 2: 389400.
  • 17
    Bregenholt, S. and Claesson, M. H., Splenic T helper cell type 1 cytokine profile and extramedullar hematopoiesis in severecombined immunodeficient (scid) mice with inflammatory bowel disease (IBD). Clin. Exp. Immunol. 1998. 111: 166172.
  • 18
    Bregenholt, S. and Claesson, M. H., Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease. Eur. J. Immunol. 1998. 28: 379389.
  • 19
    Bonhagen, T. S., Vestweber, K., Hamann, D. and Reimann, J., Expression of selectin-binding epitopes and cytokines by CD4+ T cells repopulating scid mice with colitis. Eur. J. Immunol .1998. 6:17851797.
  • 20
    Duchmann, R., Schmitt, E., Knolle, P., Meyer zum Buschenfelde, K. H. and Neurath, M., Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies tointerleukin-12. Eur. J. Immunol. 1996. 26: 934938.
  • 21
    Hurst, S. D., Sitterding, S. M., Ji, S. and Barrett, T. A., Functional differentiation of T cells in the intestine of T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 1997. 94: 39203925.
  • 22
    Sundberg, J. P., Elson, C. O., Bedigian, H. and Birkenmeier, E. H., Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 1994. 107: 17261735.
  • 23
    Cong, Y., Brandwein, S. L., McCabe, R. P., Lazenby, A., Birkenmeier, E. H., Sundberg, J. P. and Elson, C. O., CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J. Exp. Med. 1998. 187: 855864.
  • 24
    Rudolph, U., Finegold, M. J., Rich, S. S., Harriman, G. R., Srinivasan, Y., Brabet, P., Boulay, G., Bradley, A. and Birnbaumer, L., Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet. 1995. 10: 143150.
  • 25
    Ohman, L., Franzen, L., Rudolph, U., Harriman, G. R. and Hultgren Hornquist, E., Immune activation in the intestinal mucosa before the onset of colitis in Galphai2-deficient mice. Scand. J. Immunol. 2000. 52: 8090.
  • 26
    Piccirillo, C. and Shevach, E. M., Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 2001. 167: 11371140.
  • 27
    Read, S., Malmstrom, V. and Powrie, F., Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+regulatory cells that control intestinal inflammation . J. Exp. Med. 2000. 192: 295302.
  • 28
    Claesson, M. H., Bregenholt, S., Bonhagen, K., Thoma, S., Möller, P., Grusby, M. J., Leithäuser, F., Nissen, M. H. and Reimann, J., Colitis inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness and CD45RB surface phenotype. J. Immunol. 1999. 162: 37023710.
  • 29
    Bregenholt, S., Reimann, J. and Claesson, M. H., Proliferation and apoptosis of lamina propria CD4+ T cells from scid mice with inflammatory bowel disease. Eur. J. Immunol. 1998. 28: 36553663.
  • 30
    Bonhagen, K., Thoma, S., Bland, P., Bregenholt, S., Rudolphi, A., Claesson, M. H. and Reimann, J., Cytotoxic reactivity of gut lamina propria CD4+ α β T cells in scid mice with colitis. Eur. J. Immunol. 1996. 26: 30763083.
  • 31
    Bregenholt, S., Petersen, T. R. and Claesson, M. H., The majority of lamina propria CD4+ T cells from scid mice with colitis undergo Fas-mediated apoptosis in vivo. Immunol. Lett. 2001. 78: 712.
  • 32
    Wilson, D. B., Blyth, J. L. and Nowell, P. C., Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response. J. Exp Med. 1968. 128: 11571181.