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    Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J. E. and Roncarolo, M. G., A CD4+ T cell subset inhibits antigen-specific T cell responses and prevents colitis . Nature 1997. 389: 737742.
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    Brimnes, J., Reimann, J. M., Nissen, H. and Claesson, M. H., Enteric bacterial antigens activate CD4+ T cells from scid mice with inflammatory bowel disease. Eur. J. Immunol. 2001. 31: 2331.
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    Gad, M., Brimnes, J. and Claesson, M. H., CD4+ T regulatory cells from the colonic lamina propria of normal mice inhibit proliferation of enterobacteria-reactive, disease inducing Th1-cells from scid mice with colitis. Exp. Clin. Immunol .2003. 131: 3440.
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    Thornton, A. M. and Shevach, E. M., CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin-2 production . J. Exp. Med. 1998. 188: 287296.
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    Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 19691980.
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    Takahashi, T., Tagami, T., Yamazaki, Y., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ regulatory T cells constitutively expressing cytotoxic lymphocyte-associated antigen 4. J. Exp. Med. 2000. 192: 303310.
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    Roncarolo, M. G. and Levings, M. K., The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 2000. 12: 676683.
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    Shevach, E. M., CD4+CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002. 2: 389400.
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    Bregenholt, S. and Claesson, M. H., Splenic T helper cell type 1 cytokine profile and extramedullar hematopoiesis in severecombined immunodeficient (scid) mice with inflammatory bowel disease (IBD). Clin. Exp. Immunol. 1998. 111: 166172.
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    Bregenholt, S. and Claesson, M. H., Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease. Eur. J. Immunol. 1998. 28: 379389.
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    Bonhagen, T. S., Vestweber, K., Hamann, D. and Reimann, J., Expression of selectin-binding epitopes and cytokines by CD4+ T cells repopulating scid mice with colitis. Eur. J. Immunol .1998. 6:17851797.
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    Duchmann, R., Schmitt, E., Knolle, P., Meyer zum Buschenfelde, K. H. and Neurath, M., Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies tointerleukin-12. Eur. J. Immunol. 1996. 26: 934938.
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    Hurst, S. D., Sitterding, S. M., Ji, S. and Barrett, T. A., Functional differentiation of T cells in the intestine of T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 1997. 94: 39203925.
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    Sundberg, J. P., Elson, C. O., Bedigian, H. and Birkenmeier, E. H., Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 1994. 107: 17261735.
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    Cong, Y., Brandwein, S. L., McCabe, R. P., Lazenby, A., Birkenmeier, E. H., Sundberg, J. P. and Elson, C. O., CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J. Exp. Med. 1998. 187: 855864.
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    Rudolph, U., Finegold, M. J., Rich, S. S., Harriman, G. R., Srinivasan, Y., Brabet, P., Boulay, G., Bradley, A. and Birnbaumer, L., Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet. 1995. 10: 143150.
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    Ohman, L., Franzen, L., Rudolph, U., Harriman, G. R. and Hultgren Hornquist, E., Immune activation in the intestinal mucosa before the onset of colitis in Galphai2-deficient mice. Scand. J. Immunol. 2000. 52: 8090.
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    Piccirillo, C. and Shevach, E. M., Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 2001. 167: 11371140.
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    Read, S., Malmstrom, V. and Powrie, F., Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+regulatory cells that control intestinal inflammation . J. Exp. Med. 2000. 192: 295302.
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    Claesson, M. H., Bregenholt, S., Bonhagen, K., Thoma, S., Möller, P., Grusby, M. J., Leithäuser, F., Nissen, M. H. and Reimann, J., Colitis inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness and CD45RB surface phenotype. J. Immunol. 1999. 162: 37023710.
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    Bregenholt, S., Reimann, J. and Claesson, M. H., Proliferation and apoptosis of lamina propria CD4+ T cells from scid mice with inflammatory bowel disease. Eur. J. Immunol. 1998. 28: 36553663.
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    Bonhagen, K., Thoma, S., Bland, P., Bregenholt, S., Rudolphi, A., Claesson, M. H. and Reimann, J., Cytotoxic reactivity of gut lamina propria CD4+ α β T cells in scid mice with colitis. Eur. J. Immunol. 1996. 26: 30763083.
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    Bregenholt, S., Petersen, T. R. and Claesson, M. H., The majority of lamina propria CD4+ T cells from scid mice with colitis undergo Fas-mediated apoptosis in vivo. Immunol. Lett. 2001. 78: 712.
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