Inflammation and innate immunity
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Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus
Article first published online: 1 MAR 2004
DOI: 10.1002/eji.200324441
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Wald, O., Pappo, O., Safadi, R., Dagan-Berger, M., Beider, K., Wald, H., Franitza, S., Weiss, I., Avniel, S., Boaz, P., Hanna, J., Zamir, G., Eid, A., Mandelboim, O., Spengler, U., Galun, E. and Peled, A. (2004), Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur. J. Immunol., 34: 1164–1174. doi: 10.1002/eji.200324441
Publication History
- Issue published online: 23 MAR 2004
- Article first published online: 1 MAR 2004
- Manuscript Accepted: 7 FEB 2004
- Manuscript Revised: 25 JAN 2004
- Manuscript Received: 11 AUG 2003
- 1Cytokines and chemokines in the immune response to hepatitis C infection. Curr. Opin. Infect. Dis. 2001. 14: 279–287.
- 2The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns. J. Immunol. 1999. 163: 2314–2321.
- 3Life, activation and death of intrahepatic lymphocytes in chronic hepatitis C. Immunol. Rev. 2000. 174: 77–89.Direct Link:
- 4Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Vα24+ T cells and rapid elimination of effector cells by apoptosis. Eur. J. Immunol. 1998. 28: 3448–3455.
- 5Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 2000. 12: 336–341.
- 6Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. J. Immunol. 1999. 163: 6236–6243.
- 7Liver-infiltrating lymphocytes in end-stage hepatitis C virus: subsets, activation status, and chemokine receptor phenotypes. J. Hepatol. 2003. 38: 67–75.
- 8Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease. Am. J. Pathol. 2002. 160: 1445–1455.
- 9Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999. 283: 845–848.
- 10Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium. J. Immunol. 2000. 165: 6590–6598.
- 11Persistent induction of the chemokine receptor CXCR4 by TGF-β1 on synovial T cells contributes totheir accumulation within the rheumatoid synovium. J. Immunol. 2000. 165: 3423–3429.
- 12Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritis. J. Immunol. 2003. 170: 2147–2152.
- 13Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease. J. Immunol. 2000. 165: 499–508.
- 14Liver biopsy in hepatitis C. J. Hepatol. 1999. 31 Suppl 1: 43–46.
- 15
- 16Histopathologic findings in chronic hepatitis C. J. Hepatol. 1996. 24: 35–42.
- 17DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J. Virol. 2001. 75: 7059–7066.
- 18Enhanced expression of interferon-regulated genes in the liver of patients with chronic hepatitis C virus infection: detection by suppression-subtractive hybridization. J. Virol. 2001. 75: 1332–1338.
- 19Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes. Clin. Exp. Immunol. 2001. 123: 271–279.
- 20Clinicalsignificance of elevated serum interferon-inducible protein-10 levels in hepatitis C virus carriers with persistently normal serum transaminase levels. J. Viral Hepat. 2001. 8: 341–348.
- 21The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow. J. Clin. Invest. 1999. 104: 1199–1211.
- 22Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines. Nat. Immunol. 2001. 2: 515–522.
- 23AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice. J. Immunol. 2001. 167: 4686–4692.
- 24The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood 2000. 95: 3289–3296.
- 25Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1α)-dependent pathways. J. Exp. Med. 1998.187: 1–14.
- 26Immunology of the healthy liver: old questions and new insights. Gastroenterology 2001. 120: 250–260.
- 27The biology of chemokines and their receptors. Annu. Rev. Immunol. 2000. 18: 217–242.
- 28Differential expression of chemokines and chemokine receptors shapes the inflammatory response in rejecting human liver transplants. Transplantation 2001. 72: 1957–1967.
- 29Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 2003. 362: 697–703.
- 30G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat. Immunol. 2002. 3: 687–694.
- 31Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 1999. 189: 451–460.
- 32Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J. Immunol. 2002. 169: 424–433.
- 33CXCR4 mRNA expression in colon, esophageal and gastric cancers and hepatitis C infected liver. Int. J. Oncol. 1999. 14: 917–925.
- 34Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression. Am. J. Pathol. 2002. 160: 641–654.
- 35Transforming growth factor beta and the liver. Hepatology 2001. 34: 859–867.
- 36Regulation of T-cell interaction with fibronectin by transforming growth factor-beta is associated with altered Pyk2 phosphorylation. Immunology 2001. 104: 149–156.
- 37TGF-β1 enhances SDF-1α-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules. Eur. J. Immunol. 2002. 32: 193–202.
- 38Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice. Blood 2003. 102: 1951–1958.
- 39Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur. J. Immunol. 1999. 29: 2037–2045.
- 40Enhanced antitumor immunity in mice deficient in CD69. J. Exp. Med. 2003. 197: 1093–1106.
- 41The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J. Exp. Med. 1998. 188: 157–167.
- 42Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981. 1: 431–435.

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