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    Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 19691980.
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    Suri-Payer, E. and Cantor, H., Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4+CD25+ T cells. J. Autoimmun. 2001. 16: 115123.
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    Belkaid, Y., Piccirillo, C. A., Mendez, S., Shevach, E. M. and Sachs, D. L., CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002. 420: 502507.
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    Chambers, C. A. and Allison, J. P., Costimulatory regulation of T cell function. Curr. Opin. Cell Biol. 1999. 11: 203210.
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    Thornton, A. M. and Shevach, E. M., Suppressor effector function of CD4+CD25+ immunoregulatory cells is antigen nonspecific. J. Immunol. 2000. 164: 183190.
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    Salomon, B., Lenschow, D. J., Rhee, L., Ashourian, N., Singh,B., Sharpe, A. and Bluestone, J. A., B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 2000. 12: 431440.
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    Takahashi, T., Tagami,T., Yamazuki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W. and Sakaguchi, S., Dominant immmunologic self-tolerance by CD25+CD4+ regulatory T cells constitutively expressing CTLA-4. J. Exp. Med. 2000. 192: 303309.
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    Read, S., Malmstrom, S. and Powrie, F., CTLA-4 plays an essential role in the function of CD25+CD4+ regulatory cells which control intestinal inflammation. J. Exp. Med. 2000. 192: 295302.
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    Tang, Q., Henriksen, K. J., Boden, E. K., Tooley, A. J., Ye,J., Subudhi, S. K., Zheng, X. X., Strom, T. B. and Bluestone, J. A., Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J. Immunol. 2003. 171: 33483352.
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    Salomon, B. and Bluestone, J. A., Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 2001. 19: 225252.
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    Piccirillo, C. A. and Shevach, E. M., Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J. Immunol. 2001. 167: 11371140.
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    McHugh, R. S., Whitters, M. J., Piccirillo, C. A., Young, D. A., Shevach, E. M., Collins, M. and Byrne, M. C., CD4+CD25+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002. 16: 311323.
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    Gavin, M. A., Clarke, S. R., Negrou, E., Gallegos, A. and Rudensky, A., Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo. Nat. Immunol. 2001. 3: 330401.
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    Sugamura, K., Asao, H., Kondo, M., Tanaka, N., Ishii, N., Ohbo, K., Nakamura, M. and Takeshita, T., The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Ann. Rev. Immunol. 1996. 14: 179205.
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    Teague, T. K., Marrack, P., Kappler, J. W. and Vella, A. T., IL-6 rescues resting mouse T cells from apoptosis. J. Immunol. 1997. 158: 57915796.
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    Joseph, S. B., Miner, K. T. and Croft, M., Augmentation of naive Th1 and Th2 effector CD4 responses by IL-6, IL-1 and TNF. Eur. J. Immunol. 1998. 28: 277289.
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    Groux, H., O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, J. E. and Roncarolo, M. G., A CD4+ T cell subset inhibits antigen-specific T cell responses and prevents colitis. Nature 1997. 389: 737742.
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    Zheng, S. G., Gray, J. D., Ohtsuka, K., Yamagiwa, S. and Horwitz, D. A., Generation ex vivo of TGF-β-producing regulatory T cells from CD4+CD25 precursors. J. Immunol. 2002. 169: 41834189.
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    Bacchetta, R., Sartirana, C., Levings, M. K., Bordignon, C., Narula, S. and Roncarolo, M. G., Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur. J. Immunol. 2002. 32: 22372245.
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    Sadlack, B., Lohler, J., Schorle, H., Klebb, G., Haber, H., Sickel, E., Noelle, R. J. and Horak, I., Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur. J. Immunol. 1995. 25: 30533059.
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    Willerford, D. M., Chan, J., Ferry, J. A., Davivson, L., Ma,A. and Alt, F. W., Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995. 3: 521530.
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    Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Simard, J. J. L., Ohashi, P. S., Griesser, H., Tanaguchi, T., Paige, C. J. and Mak, T. W., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 1995. 268: 14721476.
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    Malek, T. R., Yu, A., Vincek, V., Scibelli, P. and Kong, L., CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice: implications for the nonredundant function of IL-2. Immunity 2002. 17: 167178.
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    Bluestone, J. A. and Abbas, A. K., Natural versus adaptive regulatory T cells: development, function and physiologic roles. Nat. Rev. Immunol. 2003. 3: 253257.
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    Aranda, R., Sydora, B. C., McAllister, P. L., Binder, S. W., Yang, H. Y., Targan, S. R. and Kronenberg, M., Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4(+), CD45RB(high) T cells to SCID recipients. J. Immunol. 1997. 158: 34643473.
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    Liu, Z. J., Geboes, K., Hellings, P., Maerten, P., Heremans,H., Vandenberghe, P., Boon, L., van Kooten, P., Rutgeerts, P. and Ceuppens, J. L., B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis. J. Immunol. 2001. 167: 18301838.
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    Egen, J. G. and Allison, J. P., Cytotoxic T lymphocyte antigen-4 accumulation in the immunologic synapse is regulated by TCR signal strength. Immunity 2002. 16: 2335.
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    Shevach, E. M. Regulatory cells in autoimmunity. Annu. Rev. Immunol. 2000. 18: 423449.
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    Kirberg, J., Baron, A., Jakob, S., Rolink, A., Karjalainen, K. and von Boehmer, H., Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 1994. 180: 2534.
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    Borriello, F., Sethna, M. P., Boyd, S. D., Schweitzer, A. N., Tivol, E. A., Jacoby, D., Strom, T. B., Simpson, E. M., Freeman, G. J. and Sharpe, A. H., B7–1 and B7–2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 1997. 6: 303313.