• 1
    Waldmann, T. A. and Tagaya, Y., The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NKcell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 1999. 17: 1949.
  • 2
    Lodolce, J. P., Boone, D. L., Chai, S., Swain, R. E., Dassopoulos, T., Trettin, S. and Ma, A., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998. 9: 669676.
  • 3
    Kennedy, M. K., Glaccum, M., Brown, S. N., Butz, E. A., Viney, J. L., Embers, M., Matsuki, N., Charrier, K., Sedger, L., Willis, C. R. et al., Reversible defects in natural killer and memory CD8 T cell lineages in interleukin-15-deficient mice. J. Exp. Med. 2000. 191: 771780.
  • 4
    Fehniger, T. A., Suzuki, K., Ponnappan, A., VanDeusen, J. B., Cooper, M. A., Florea, S. M., Freud, A. G., Robinson, M. L., Durbin, J. and Caligiuri, M. A., Fatal leukemia in interleukin-15 transgenic mice follows early expansion in natural killer and memory phenotype CD8+ T cells. J. Exp. Med. 2001. 193: 219231.
  • 5
    Bamford, R. N., Battiata, J. D., Burton, J. D., Sharma, H. and Waldmann, T. A., Interleukin(IL)-15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region/IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc. Natl. Acad. Sci. USA 1996. 93: 28972902.
  • 6
    Onu, A., Pohl, T., Krause, H. and Bulfone-Paus, S., Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J. Immunol. 1997. 158: 255262.
  • 7
    Blauvelt, A., Asada, H., Klaus-Kovtun, V., Altman, D. J., Lucey, D. R. and Katz, S. I., Interleukin-15 mRNA is expressed by keratinocytes, Langerhans cells, and blood-derived dendritic cells and is down-regulated by ultraviolet B irradiation. J. Invest. Dermatol. 1996. 106: 10471052.
  • 8
    Mohamadzadeh, M., Berard, F., Essert, G., Chalouni, C., Pulendran, B., Davoust, J., Bridges, G., Palucka, A. K. and Banchereau, J., Interleukin-15 skews monocyte differentiation into dendritic cells with features of Langerhans cells. J. Exp. Med. 2001. 194: 10131019.
  • 9
    Rückert, R., Asadullah, K., Seifert, M., Budagian, V. M., Arnold, R., Trombotto, C., Paus, R. and Bulfone-Paus, S., Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J. Immunol. 2000. 165: 22402250.
  • 10
    Hayday, A., Theodoridis, E., Ramsburg, E. and Shires, J., Intraepithelial lymphocytes: exploring the third way in immunology. Nat. Immunol. 2001. 2: 9971003.
  • 11
    Carding, S. R. and Egan, P. J., γ δ T cells: functional plasticity and heterogeneity. Nat. Rev. Immunol. 2002. 2: 336345.
  • 12
    Saitou, M., Sugai, S., Tanaka, T., Shimouchi, K., Fuchs, E., Narumiya, S. and Kakizuka, A., Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 1995. 374: 159162.
  • 13
    Beissert, S., He, H.-T., Hueber, A.-O., Lelluch, A. O., Metze, D., Mehling, A., Luger, T. A., Schwarz, T. and Grabbe, S., Impaired cutaneous immune responses in Thy-1-deficient mice. J. Immunol. 1998. 161: 52965302.
  • 14
    Ku, C. C., Murakami, M., Sakamoto, A., Kappler, J. and Marrack P., Control of homeostasis of CD8+ T cells by opposing cytokines. Science 2000. 288: 675678.
  • 15
    Bulfone-Paus, S., Ungureanu, D., Pohl, T., Lindner, G., Paus, R., Rückert, R., Krause, H. and Kunzendorf, U., Interleukin-15 protects from lethal apoptosis in vivo. Nat. Med. 1997. 3: 11241128.
  • 16
    Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Suzuki, H., Nakashima, I., Nishiyama, Y. and Yoshikai, Y., A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology 2000. 275: 5766.
  • 17
    Ohteki, T., Suzue, K., Maki, C., Ota, T. and Koyasu, S., Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat. Immunol. 2001. 2: 11381143.
  • 18
    Howie, S., Norval, M. and Maingay, J., Exposure to low-dose ultraviolet irradiation suppresses delayed-type hypersensitivity to herpes simplex virus in mice. J. Invest. Dermatol. 1986. 86: 125128.
  • 19
    Akiba, H., Kehren, J., Ducluzeau, M. T., Krasteva, M., Horand, F., Kaiserlian, D., Kaneko, F. and Nicolas, J. F., Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic T cells inducing keratinocyte apoptosis. J. Immunol. 2002. 68: 30793087.
  • 20
    Armitage, R. J., Macduff, B. M., Eisenman, J., Paxton, R. and Grabstein, K. H., IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 1995. 154: 483490.
  • 21
    Allan, R. S., Smith, C. M., Belz, G. T., van Lint, A. L., Wakim, L. M., Heath, W. R. and Carbone, F. R., Epidermal viral immunity induced by CD8α dendritic cells but not by Langerhans cells. Science 2003. 301: 19251928.
  • 22
    Stanley, M. A., Imiquimod and the imidazoquinolones: mechanism of action and therapeutical potential. Clin. Exp. Dermatol. 2002. 27: 571577.
  • 23
    Gunzer, M., Weishaupt, C., Planelles, L. and Grabbe, S., Two-step negative enrichment of CD4+ and CD8+ T cells from murine spleen via nylon wool adherence and an optimized antibody cocktail. J. Immunol. Methods 2001. 258: 5563.
  • 24
    Mehling, A., Loser, K., Varga, G., Metze, D., Luger, T. A., Schwarz, T., Grabbe, S. and Beissert, S., Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J. Exp. Med. 2001. 194: 615628.