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  • 1
    Altman, J. D., Moss, P. A., Goulder, P. J., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J. and Davis, M. M., Phenotypic analysis of antigen-specific T lymphocytes. Science 1996. 274: 9496.
  • 2
    Luxembourg, A. T., Borrow, P., Teyton, L., Brunmark, A. B., Peterson, P. A. and Jackson, M. R., Biomagnetic isolation of antigen-specific CD8+ T cells usable in immunotherapy. Nat. Biotechnol. 1998. 16: 281285.
  • 3
    Keenan, R. D., Ainsworth, J., Khan, N., Bruton, R., Cobbold, M., Assenmacher, M., Milligan, D. W. and Moss, P. A., Purification of cytomegalovirus-specific CD8 T cells from peripheral blood using HLA-peptide tetramers. Br. J. Haematol. 2001. 115: 428434.
  • 4
    McDermott, A. B., Spiegel, H. M., Irsch, J., Ogg, G. S. and Nixon, D. F., A simple and rapid magnetic bead separation technique for the isolation of tetramer-positive virus-specific CD8 T cells. Aids 2001. 15: 810812.
  • 5
    Lechner, F., Wong, D. K., Dunbar, P. R., Chapman, R., Chung, R. T., Dohrenwend, P., Robbins, G., Phillips, R., Klenerman, P. and Walker, B. D., Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 2000. 191: 14991512.
  • 6
    Urbani, S., Boni, C., Missale, G., Elia, G., Cavallo, C., Massari, M., Raimondo, G. and Ferrari, C., Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C. J. Virol. 2002. 76: 1242312434.
  • 7
    Lechner, F., Gruener, N. H., Urbani, S., Uggeri, J., Santantonio, T., Kammer, A. R., Cerny, A., Phillips, R., Ferrari, C., Pape, G. R. and Klenerman, P., CD8+ T lymphocyte responses are induced during acute hepatitis C virus infection but are not sustained. Eur. J. Immunol. 2000. 30: 24792487.
  • 8
    Lauer, G. M., Ouchi, K., Chung, R. T., Nguyen, T. N., Day, C. L., Purkis, D. R., Reiser, M., Kim, A. Y., Lucas, M., Klenerman, P. and Walker, B. D., Comprehensive analysis of CD8+-T cell responses against hepatitis C virus reveals multiple unpredicted specificities. J. Virol. 2002. 76: 61046113.
  • 9
    Barnes, E., Harcourt, G., Brown, D., Lucas, M., Phillips, R., Dusheiko, G. and Klenerman, P., The dynamics of T-lymphocyte responses during combination therapy for chronic hepatitis C virus infection. Hepatology 2002. 36: 743754.
  • 10
    He, X. S., Rehermann, B., Lopez-Labrador, F. X., Boisvert, J., Cheung, R., Mumm, J., Wedemeyer, H., Berenguer, M., Wright, T. L., Davis, M. M. and Greenberg, H. B., Quantitative analysis of hepatitis C virus-specific CD8+ T cells in peripheral blood and liver using peptide-MHC tetramers. Proc. Natl. Acad. Sci. USA 1999. 96: 56925697.
  • 11
    Gervois, N., Guilloux, Y., Diez, E. and Jotereau, F., Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions. J. Exp. Med. 1996. 183: 24032407.
  • 12
    Pittet, M. J., Valmori, D., Dunbar, P. R., Speiser, D. E., Lienard, D., Lejeune, F., Fleischhauer, K., Cerundolo, V., Cerottini, J. C. and Romero, P., High frequencies of naive Melan-A/MART-1-specific CD8+ T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals. J. Exp. Med. 1999. 190: 705715.
  • 13
    Dunbar, P. R., Smith, C. L., Chao, D., Salio, M., Shepherd, D., Mirza, F., Lipp, M., Lanzavecchia, A., Sallusto, F., Evans, A., Russell-Jones, R., Harris, A. L. and Cerundolo, V., A shift in the phenotype of melan-A-specific CTL identifies melanoma patients with an active tumor-specific immune response. J. Immunol. 2000. 165: 66446652.
  • 14
    Zippelius, A., Pittet, M. J., Batard, P., Rufer, N., de Smedt, M., Guillaume, P., Ellefsen, K., Valmori, D., Lienard, D., Plum, J., MacDonald, H. R., Speiser, D. E., Cerottini, J. C. and Romero, P., Thymic selection generates a large T cell pool recognizing a self-peptide in humans. J. Exp. Med. 2002. 195: 485494.
  • 15
    Appay, V., Dunbar, P. R., Callan, M., Klenerman, P., Gillespie, G. M., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., Little, S., Havlir, D. V., Richman, D. D., Gruener, N., Pape, G., Waters, A., Easterbrook, P., Salio, M., Cerundolo, V., McMichael, A. J. and Rowland-Jones, S. L., Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 2002. 8: 379385.
  • 16
    Barnes, E., Lauer, G., Walker, B. and Klenerman, P., T cell failurein hepatitis C virus infection. Viral. Immunol. 2002. 15: 285293.
  • 17
    Sun, Y., Iglesias, E., Samri, A., Kamkamidze, G., Decoville,T., Carcelain, G. and Autran, B., A systematic comparison of methods to measure HIV-1 specific CD8 T cells. J. Immunol. Methods 2003. 272: 2334.
  • 18
    Willberg, C., Barnes, E. and Klenerman, P., HCV immunology – death and the maiden T cell. Cell Death Differ. 2003. 10 Suppl. 1: S3947.
  • 19
    Day, C. L., Seth, N. P., Lucas, M., Appel, H., Gauthier, L., Lauer, G. M., Robbins, G. K., Szczepiorkowski, Z. M., Casson, D. R., Chung, R. T., Bell, S., Harcourt, G., Walker, B. D., Klenerman, P. and Wucherpfennig, K. W., Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J. Clin. Invest. 2003. 112: 831842.
  • 20
    Karadimitris, A., Gadola, S., Altamirano, M., Brown, D., Woolfson, A., Klenerman, P., Chen, J. L., Koezuka, Y., Roberts, I. A., Price, D. A., Dusheiko, G., Milstein, C., Fersht, A., Luzzatto, L. and Cerundolo, V., Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc. Natl. Acad. Sci. USA 2001. 98: 32943298.
  • 21
    Bunce, M., O'Neill, C. M., Barnardo, M. C., Krausa, P., Browning, M. J., Morris, P. J. and Welsh, K. I., Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 1995. 46: 355367.