SEARCH

SEARCH BY CITATION

  • 1
    Hunter, R. L., Overview of vaccine adjuvants: present and future. Vaccine 2002. 20 Suppl 3: S7S12.
  • 2
    Janeway, C. A. Jr., Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 1989. 54 Pt 1: 113.
  • 3
    Janeway, C. A. Jr., The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 1992. 13: 1116.
  • 4
    Matzinger, P., Tolerance, danger, and the extended family. Annu. Rev. Immunol. 1994. 12: 9911045.
  • 5
    Akira, S. and Hemmi, H., Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 2003. 85: 8595.
  • 6
    Beutler, B., Hoebe, K., Du, X. and Ulevitch, R. J., How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol. 2003. 74: 479485.
  • 7
    Gallucci, S., Lolkema, M., Matzinger, P., Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 1999. 5: 12491254.
  • 8
    Shi, Y., Zheng, W. and Rock, K. L., Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc. Natl. Acad. Sci. U S A 2000. 97: 1459014595.
  • 9
    Shi, Y. and Rock, K. L., Cell death releases endogenous adjuvants that selectively enhance immune surveillance of particulate antigens. Eur. J. Immunol. 2002. 32: 155162.
  • 10
    Scaffidi, P., Misteli, T. and Bianchi, M. E., Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002. 418: 191195.
  • 11
    Li, M., Carpio, D. F., Zheng, Y., Bruzzo, P., Singh, V., Ouaaz, F., Medzhitov, R. M. and Beg, A. A., An essential role of the NF-κB/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J. Immunol. 2001. 166: 71287135.
  • 12
    Dinarello, C. A., Interleukin-1. Cytokine Growth Factor Rev. 1997. 8: 253265.
  • 13
    Calandra, T. and Roger, T., Macrophage migration inhibitory factor: a regulator of innate immunity. Nat. Rev. Immunol. 2003. 3: 791800.
  • 14
    Collins, L. V., Hajizadeh, S., Holme, E., Jonsson, I. M. and Tarkowski, A., Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J. Leukoc. Biol. 2004. In press.
  • 15
    Asea, A., Kraeft, S-K., Kurt-Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R. W., Koo, G. L. and Calderwood, S. K., HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat. Med. 2000. 6: 435442.
  • 16
    Shi, Y., Evans, J. E. and Rock, K. L., Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003. 425: 516521.
  • 17
    Wang, H., Bloom, O., Zhang, M., Ombrellino, M., Che, J., Vishnubhakat, J. M., Frazier, A., Ivanova, S., Borovikova, L., Manogue, K. et al., HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999. 285: 248251.
  • 18
    Andersson, U., Wang, H., Palmblad, K., Aveberger, A. C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H. and Tracey, K. J., High mobility group 1 protein (HMG-1) stimulates pro-inflammatory cytokine synthesis in human monocytes. J. Exp. Med. 2000. 192: 565570.
  • 19
    Goodwin, G. H., Sanders, C. and Johns, E. W., A new group of chromatin-associated proteins witha high content of acidic and basic amino acids. Eur. J. Biochem. 1973. 38: 1419.
  • 20
    Bustin, M., Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol. Cell Biol. 1999. 19: 52375246.
  • 21
    Agresti, A. and Bianchi, M. E., HMGB proteins and gene expression. Curr. Opin. Genet. Dev. 2003.13: 170178.
  • 22
    Paonessa, G., Frank, R. and Cortese, R., Nucleotide sequence of rat liver HMG1 cDNA. Nucleic Acids Res. 1987. 15: 9077.
  • 23
    Wen, L., Huang, J. K., Johnson, B. H. and Reeck, G. R., A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. Nucleic Acids Res. 1989. 17: 11971214.
  • 24
    Rauvala, H., Merenmies, J., Pihlaskari, R., Korkolainen, M., Huhtala, M. L. and Panula, P., The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons. J. Cell Biol. 1988. 107: 22932305.
  • 25
    Ferrari, S., Finelli, P., Rocchi, M. and Bianchi, M. E., The activegene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13. Genomics 1996. 35: 367371.
  • 26
    Li, J., Kokkola, R., Tabibzadeh, S., Yang, R., Ochani, M., Qiang, X., Harris, H. E., Czura, C. J., Wang, H., Ulloa, L. et al., Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol. Med. 2003. 9: 3745.
  • 27
    Calogero, S., Grassi, F., Aguzzi, A., Voigtlander, T., Ferrier, P., Ferrari, S. and Bianchi, M. E., The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat. Genet. 1999. 22: 276280.
  • 28
    Melvin, V. S. and Edwards, D. P., Coregulatory proteins in steroid hormone receptor action: the role of chromatin high mobility group proteins HMG-1 and -2. Steroids 1999. 64: 576586.
  • 29
    Melvin, V. S., Roemer, S. C., Churchill, M. E. and Edwards, D. P., The C-terminal extension (CTE) of the nuclear hormone receptor DNA binding domain determines interactions and functional response to the HMGB-1/-2 co-regulatory proteins. J. Biol. Chem. 2002. 277: 2511525124.
  • 30
    Jayaraman, L., Moorthy, N. C., Murthy, K. G., Manley, J. L., Bustin, M. and Prives, C., High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes Dev. 1998. 12: 462472.
  • 31
    Agrawal, A. and Schatz, D. G., RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends inV(D)J recombination. Cell 1997. 89: 4353.
  • 32
    He, Q., Liang, C. H. and Lippard, S. J., Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin. Proc. Natl. Acad. Sci. U S A 2000. 97: 57685772.
  • 33
    Falciola, L., Spada, F., Calogero, S., Langst, G., Voit, R., Grummt, I. and Bianchi, M. E., High mobility group 1 protein is not stably associated with the chromosomes of somatic cells. J. Cell Biol. 1997. 137: 1926.
  • 34
    Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A. and Bianchi, M. E., Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J. 2003. 22: 55515560.
  • 35
    Wolffe, A. P., Architectural transcription factors. Science 1994. 264: 11001101.
  • 36
    Muller, S., Ronfani, L. and Bianchi, M. E., Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function. J. Intern. Med. 2004, 255: 332343.
  • 37
    Seyedin, S. M., Pehrson, J. R. and Cole, R. D., Loss of chromosomal high mobility group proteins HMG1 and HMG2 when mouse neuroblastoma and Friend erythroleukemia cells become committed to differentiation. Proc. Natl. Acad. Sci. U S A 1981. 78: 59885992.
  • 38
    Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D. et al., The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of RAGE and amphoterin in the developing nervous system. J. Biol. Chem. 1995. 270: 2575225761.
  • 39
    Huttunen, H. J., Fages, C. and Rauvala, H., Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways. J.  Biol. Chem. 1999. 274: 1991919924.
  • 40
    Rouhiainen, A., Imai, S., Rauvala, H. and Parkkinen, J., Occurrenceof amphoterin (HMG1) as an endogenous protein of human platelets that is exported to the cell surface upon platelet activation. Thromb. Haemost. 2000. 84: 10871094.
  • 41
    Parkkinen, J., Raulo, E., Merenmies, J., Nolo, R., Kajander,E. O., Baumann, M. and Rauvala, H., Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation. J. Biol. Chem. 1993. 268: 1972619738.
  • 42
    Sparatore, B., Pedrazzi, M., Passalacqua, M., Gaggero, D., Patrone, M., Pontremoli, S. and Melloni, E., Stimulation of erythroleukaemia cell differentiation by extracellular high-mobility group-box protein 1 is independent of the receptor for advanced glycation end-products. Biochem. J. 2002. 363: 529535.
  • 43
    Gardella, S., Andrei, C., Ferrera, D., Lotti, L. V., Torrisi, M. R., Bianchi, M. E. and Rubartelli, A., The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep. 2002. 3: 9951001.
  • 44
    Wang, H., Vishnubhakat, J. M., Bloom, O., Zhang, M., Ombrellino, M., Sama, A. and Tracey, K. J., Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery 1999. 126: 389392.
  • 45
    Sparatore, B., Patrone, M., Passalacqua, M., Pedrazzi, M., Gaggero, D., Pontremoli, S. and Melloni, E., Extracellular processing of amphoterin generates a peptide active on erythroleukaemia cell differentiation. Biochem. J. 2001. 357: 569574.
  • 46
    Sass, G., Heinlein, S., Agli, A., Bang, R., Schumann, J. and Tiegs, G., Cytokine expression in three mouse models of experimental hepatitis. Cytokine 2002. 19: 115120.
  • 47
    Fang, W. H., Yao, Y. M., Shi, Z. G., Yu, Y., Wu, Y., Lu, L. R. and Sheng, Z. Y., The significance of changes in high mobility group-1 protein mRNA expression in rats after thermal injury. Shock 2002. 17: 329333.
  • 48
    Schmidt, A. M., Yan, S. D., Yan, S. F. and Stern, D. M., The biology of the receptor for advanced glycation end products and its ligands. Biochim. Biophys. Acta 2000. 1498: 99111.
  • 49
    Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C. et al., Blockade of RAGE-amphoterin signaling suppresses tumour growth and metastases. Nature 2000. 405: 354360.
  • 50
    Degryse, B., Bonaldi, T., Scaffidi, P., Muller, S., Resnati,M., Sanvito, F., Arrigoni, G. and Bianchi, M. E., The high mobility group (hmg) boxes of thenuclear protein hmg1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. J. Cell Biol. 2001. 152: 11971206.
  • 51
    Mistry, A. R., Falciola, L., Monaco, L., Tagliabue, R., Acerbis, G., Knight, A., Harbottle, R. P., Soria, M., Bianchi, M. E., Coutelle, C. and Hart, S. L., Recombinant HMG1 protein produced in Pichia pastoris: a nonviral gene delivery agent. Biotechniques 1997. 22: 718729.
  • 52
    Treutiger, C. J., Mullins, G. E., Johansson, A. S., Rouhiainen, A., Rauvala, H. M., Erlandsson-Harris, H., Andersson, U., Yang, H., Tracey, K. J., Andersson, J. and Palmblad, J. E., High mobility group 1 B-box mediates activation of human endothelium. J. Intern. Med. 2003. 254: 375385.
  • 53
    Palumbo, R., Sampaolesi, M., De Mayis, F., Tonlorenzi, R., Colombetti, S., Mondino, A., Cossu, G. and Bianchi, M. E., Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J. Cell Biol. 2004. 164: 441449.
  • 54
    Park, J. S., Svetkauskaite, D., He, Q., Kim, J. Y., Strassheim, D., Ishizaka, A. and Abraham, E., Involvement of TLR 2 and TLR 4 in cellular activation by high mobility group box 1 protein (HMGB1). J. Biol. Chem. 2004. 279: 73707377.
  • 55
    Park, J. S., Arcaroli, J., Yum, H. K., Yang, H., Wang, H., Yang, K. Y., Choe, K. H., Strassheim, D., Pitts, T. M., Tracey, K. J. and Abraham, E., Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am. J. Physiol. Cell. Physiol. 2003. 284: C870–C879.
  • 56
    Fiuza, C., Bustin, M., Talwar, S., Tropea, M., Gerstenberger, E., Shelhamer, J. H. and Suffredini, A. F., Inflammation-promoting activity of HMGB1 on human microvascular endothelialcells. Blood 2003. 101: 26522660.
  • 57
    Abraham, E., Arcaroli, J., Carmody, A., Wang, H. and Tracey,K. J., HMG-1 as a mediator of acute lung inflammation. J. Immunol. 2000. 165: 29502954.
  • 58
    Pullerits, R., Jonsson, I. M., Verdrengh, M., Bokarewa, M., Andersson, U., Erlandsson-Harris, H. and Tarkowski, A., High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis. Arthritis Rheum. 2003. 48: 16931700.
  • 59
    Zetterstrom, C. K., Bergman, T., Rynnel-Dagoo, B., Erlandsson Harris, H., Soder, O., Andersson, U. and Boman, H. G., High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid. Pediatr. Res. 2002. 52: 148154.
  • 60
    Read, C. M., Cary, P. D., Crane-Robinson, C., Driscoll, P. C. and Norman, D. G., Solution structure of a DNA-binding domain from HMG1. Nucleic Acids Res. 1993. 21: 34273436.
  • 61
    Weir, H. M., Kraulis, P. J., Hill, C. S., Raine, A. R., Laue, E. D. and Thomas, J. O., Structure of the HMG box motif in the B-domain of HMG1. EMBO J. 1993. 12: 13111319.
  • 62
    Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H. E., Susarla, S. M., Ulloa, L., Wang, H., DiRaimo, R. et al., Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl. Acad. Sci. U S A 2004. 101: 296301.
  • 63
    Ombrellino, M., Wang, H., Ajemian, M. S., Talhouk, A., Sher,L. A., Friedman, S. G. and Tracey, K. J., Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet 1999. 354: 14461447.
  • 64
    O'Connor, K. A., Hansen, M. K., Rachal Pugh, C., Deak, M. M., Biedenkapp, J. C., Milligan, E. D., Johnson, J. D., Wang, H., Maier, S. F., Tracey, K. J. and Watkins, L. R., Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. Cytokine 2003. 24: 254265.
  • 65
    Kokkola, R., Sundberg, E., Ulfgren, A. K., Palmblad, K., Li,J., Wang, H., Ulloa, L., Yang, H., Yan, X. J., Furie, R. et al., High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum. 2002. 46: 25982603.
  • 66
    Taniguchi, N., Kawahara, K., Yone, K., Hashiguchi, T., Yamakuchi, M., Goto, M., Inoue, K., Yamada, S., Ijiri, K., Matsunaga, S. et al., High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Arthritis Rheum. 2003. 48: 971981.
  • 67
    Ulfgren, A.-K., Grundtman, C., Alexandersson, H., Borg, C., Andersson, U., Erlandsson Harris, H. and Lundberg, I., Cortocosteroid-therapy downregulates the proinflammatory mediator HMGB1 in myositis patients. Arthritis Rheum. 2004. In press.
  • 68
    Remick, D., Manohar, P., Bolgos, G., Rodriguez, J., Moldawer, L. and Wollenberg, G., Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture. Shock 1995. 4: 8995.
  • 69
    Calandra, T., Echtenacher, B., Roy, D. L., Pugin, J., Metz, C. N., Hultner, L., Heumann, D., Mannel, D., Bucala, R. and Glauser, M. P., Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat. Med. 2000. 6: 164170.
  • 70
    Kokkola, R., Li, J., Sundberg, E., Aveberger, A. C., Palmblad, K., Yang, H., Tracey, K. J., Andersson, U. and Harris, H. E., Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity. Arthritis Rheum. 2003. 48: 20522058.
  • 71
    Ulloa, L., Ochani, M., Yang, H., Tanovic, M., Halperin, D., Yang, R., Czura, C. J., Fink, M. P. and Tracey, K. J., Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc. Natl. Acad. Sci. U S A 2002. 99: 1235112356.
  • 72
    Yang, R., Gallo, D. J., Baust, J. J., Uchiyama, T., Watkins,S. K., Delude, R. L. and Fink, M. P., Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am. J. Physiol. Gastrointest. Liver Physiol. 2002. 283: G212–G221.
  • 73
    Sappington, P. L., Yang, R., Yang, H., Tracey, K. J., Delude, R. L. and Fink, M. P., HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 2002. 123: 790802.