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    Reith, W. and Mach, B., The bare lymphocyte syndrome and the regulation of MHC expression. Annu. Rev. Immunol. 2001. 19: 331373.
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    Ting, J. P. and Trowsdale, J., Genetic control of MHC class II expression. Cell 2002. 109 Suppl: S21–S33.
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    Steimle, V., Durand, B., Barras, E., Zufferey, M., Hadam, M. R., Mach, B. and Reith, W., A novel DNA binding regulatory factor is mutated in primary MHC class II deficiency (Bare Lymphocyte Syndrome). Genes Dev. 1995. 9: 10211032.
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    Masternak, K., Barras, E., Zufferey, M., Conrad, B., Corthals, G., Aebersold, R., Sanchez, J. C., Hochstrasser, D. F., Mach, B. and Reith, W., A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. Nat. Genet. 1998. 20: 273277.
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    Nagarajan, U. M., Louis-Plence, P., DeSandro, A., Nilsen, R., Bushey, A. and Boss, J. M., RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. Immunity 1999. 10: 153162.
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    Durand, B., Sperisen, P., Emery, P., Barras, E., Zufferey, M., Mach, B. and Reith, W., RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. EMBO J. 1997. 16: 10451055.
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    Moreno, C. S., Beresford, G. W., Louis-Plence, P., Morris, A. C. and Boss, J. M., CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 1999. 10: 143151.
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    Masternak, K., Muhlethaler-Mottet, A., Villard, J., Zufferey, M., Steimle, V. and Reith, W., CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 2000. 14: 11561166.
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    Boss, J. M. and Jensen, P. E., Transcriptional regulation of the MHC class II antigen presentation pathway. Curr. Opin. Immunol. 2003. 15: 105111.
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    Westerheide, S. D., Louis-Plence, P., Ping, D., He, X. F. and Boss, J. M., HLA-DMA and HLA-DMB gene expression functions through the conserved S-X-Y region. J. Immunol. 1997. 158: 48124821.
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    Taxman, D. J., Cressman, D. E. and Ting, J. P., Identification of class II transcriptional activator-induced genes by representational difference analysis: discoordinate regulation of the DN alpha / DO beta heterodimer. J. Immunol. 2000. 165: 14101416.
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    Nagarajan, U. M., Lochamy, J., Chen, X., Beresford, G. W., Nilsen, R., Jensen, P. E. and Boss, J. M., Class II transactivator is required for maximal expression of HLA-DOB in B cells. J. Immunol. 2002. 168: 17801786.
  • 20
    Khalil, H., Deshaies, F., Bellemare-Pelletier, A., Brunet, A., Faubert, A., Azar, G. A. and Thibodeau, J., Class II transactivator-induced expression of HLA-DO(beta) in HeLa cells. Tissue Antigens 2002. 60: 372382.
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    Martin, B. K., Chin, K. C., Olsen, J. C., Skinner, C. A., Dey, A., Ozato, K. and Ting, J. P., Induction of MHC class I expression by the MHC class II transactivator CIITA. Immunity 1997. 6: 591600.
  • 22
    Gobin, S. J., Peijnenburg, A., Keijsers, V. and van den Elsen, P. J., Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Immunity 1997. 6: 601611.
  • 23
    Gourley, T., Roys, S., Lukacs, N. W., Kunkel, S. L., Flavell, R. A. and Chang, C. H., A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production. Immunity 1999. 10: 377386.
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    Gourley, T. S., Patel, D. R., Nickerson, K., Hong, S. C. and Chang, C. H., Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator. J. Immunol. 2002. 168: 44144419.
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    Sisk, T. J., Gourley, T., Roys, S. and Chang, C. H., MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300. J. Immunol. 2000. 165: 25112517.
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    Otten, L. A., Tacchini-Cottier, F., Lohoff, M., Annunziato, F., Cosmi, L., Scarpellino, L., Louis, J., Steimle, V., Reith, W. and Acha-Orbea, H., Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes. J. Immunol. 2003. 170: 11501157.
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    Gourley, T. S. and Chang, C. H., Cutting edge: the class II transactivator prevents activation-induced cell death by inhibiting Fas ligand gene expression. J. Immunol. 2001. 166: 29172921.
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    Zhu, X. S. and Ting, J. P., A 36-amino-acid region of CIITA is an effective inhibitor of CBP: novel mechanism of gamma interferon-mediated suppression of collagen alpha(2)(I) and other promoters. Mol. Cell Biol. 2001. 21: 70787088.
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    Lima, R. G., Van Weyenbergh, J., Saraiva, E. M., Barral-Netto, M., Galvao-Castro, B. and Bou-Habib, D. C., The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells. J. Infect. Dis. 2002. 185: 15611566.
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    Okamoto, H., Asamitsu, K., Nishimura, H., Kamatani, N. and Okamoto, T., Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA. Biochem. Biophys. Res. Commun. 2000. 279: 494499.
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    Wong, A. W., Brickey, W. J., Taxman, D. J., van Deventer, H. W., Reed, W., Gao, J. X., Zheng, P., Liu, Y., Li, P., Blum, J. S. et al., CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat. Immunol. 2003. 4: 891898.
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    Landmann, S., Muhlethaler-Mottet, A., Bernasconi, L., Suter, T., Waldburger, J. M., Masternak, K., Arrighi, J. F., Hauser, C., Fontana, A. and Reith, W., Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression. J. Exp. Med. 2001. 194: 379392.
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    Nagarajan, U. M., Bushey, A. and Boss, J. M., Modulation of gene expression by the MHC class IItransactivator. J. Immunol. 2002. 169: 50785088.
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    Muhlethaler-Mottet, A., Otten, L. A., Steimle, V. and Mach, B., Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 1997. 16: 28512860.
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    Waldburger, J. M., Suter, T., Fontana, A., Acha-Orbea, H. and Reith, W., Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene. J. Exp. Med. 2001. 194: 393406.
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    Muhlethaler-Mottet, A., Di Berardino, W., Otten, L. A. and Mach, B., Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. Immunity 1998. 8: 157166.
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    Piskurich, J. F., Wang, Y., Linhoff, M. W., White, L. C. and Ting, J. P., Identification of distinct regions of 5′ flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene. J. Immunol. 1998. 160: 233240.
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