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Frontline: Interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR γ δ T cells and interleukin-18-binding protein
Article first published online: 22 JUL 2004
DOI: 10.1002/eji.200425124
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Siegmund, B., Sennello, Joseph A., Lehr, Hans A., Senaldi, G., Dinarello, Charles A. and Fantuzzi, G. (2004), Frontline: Interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR γ δ T cells and interleukin-18-binding protein. Eur. J. Immunol., 34: 2356–2364. doi: 10.1002/eji.200425124
Publication History
- Issue published online: 5 AUG 2004
- Article first published online: 22 JUL 2004
- Manuscript Accepted: 26 APR 2004
- Manuscript Received: 18 MAR 2004
- 1Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1. Nature 1989. 337: 270–278.
- 2IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells. J. Immunol. 1999. 162: 7256–7261.
- 3Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 1989. 4: 729–734.
- 4Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell 1988. 54: 903–909.
- 5Interferon regulator factor-1 is required for a T helper 1 immune response in vivo. Immunity 1997. 6: 681–689.
- 6Reduced incidence and severity of antigen-induced autoimmune diseases in mice lacking interferon regulatory factor-1. J. Exp. Med. 1997. 185: 231–238.
- 7Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion ofIL-5. J. Immunol. 1996. 157: 1261–1270.
- 8A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J. Immunol. 1997. 159: 6276–6282.
- 9In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium. J. Clin. Invest. 2000. 106: 403–410.
- 10The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-α/β+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J. Exp. Med. 1998. 187: 967–972.
- 11The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. Immunity 1997. 7: 243–254.
- 12Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity 1997. 6: 673–680.
- 13Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity. Eur. J. Immunol. 2001. 31: 369–375.Direct Link:
- 14The promoter of IL-18 binding protein; activation byan IFN-γ-induced complex of IFN regulatory factor 1 and CCAT/enhancer binding protein β. Proc. Nat. Acad. Sci. USA 2002. 99: 16957–16962.
- 15Differential regulationof interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-γ primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 2003. 198: 1265–1276.
- 16Requirement for IRF-1 in the microenvironment supporting development of natural killer cells. Nature 1998. 391: 700–703.
- 17A novel method for the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990. 98: 694–702.
- 18The immunology of mucosal models of inflammation. Annu. Rev. Immunol. 2002. 20: 495–549.
- 19Leptin: a pivotal mediator of intestinal inflammation. Gastroenterology 2002. 122: 2011–2025.
- 20IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 2001. 19: 623–655.
- 21Cis3/socs3/ssi3 plays a negative regulatory role in stat3 activation and intestinal inflammation. J. Exp. Med. 2001. 193: 471–482.
- 22Interleukin-12 induced interferon-γ increases inflammation in acute dextran sulfate sodium induced colitis in mice. Eur. Cytokine Netw. 2000. 11: 67–74.
- 23Protection of the intestinal mucosa by intraepithelial γ δ T cells. Proc. Natl. Acad. Sci. U S A 2002. 99: 14338–14343.
- 24Role of γ δ T cells in the inflammatory response of experimental colitis mice. J. Immunol. 2003. 171: 5507–5513.
- 25Neutralization of IL-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production. Am. J. Physiol. 2001. 281: R1264-R1273.
- 26Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production in mice. Gastroenterology 2001. 121: 1372–1379.
- 27IL-15. Insights from characterizing IL-15-deficient mice. In Fantuzzi, G. (Ed.) Cytokine Knockouts , 2nd Edition. Humana Press, Totowa, NJ, USA 2003, pp 281–301.
- 28Protection against the mortality associated with disease models mediated by TNF and IFN-γ in mice lacking IFN regulatory factor-1. J. Immunol. 1999. 163: 6820–6826.
- 29Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J. Exp. Med. 2001. 194: 1207–1218.
- 30Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cylooxygenase-2. J. Clin. Invest. 2000. 105: 469–478.
- 31Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon γ-dependent cyclooxygenase 2 expression. J. Exp. Med. 2000. 191: 2131–2144.
- 32Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J. Immunol. 2003. 171: 2937–2944.
- 33Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice. Am. J. Physiol. 1998. 274: G472-G479.
- 34Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ cells. Immunity 1994. 1: 553–562.
- 35
- 36The critical role of interleukin-4 but not interferon γ in the pathogenesis of colitis in T-cell receptor α-mutant mice. Gastroenterology 1999. 116: 320–326.
- 37IL-12, but not IFNγ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J. Immunol. 1998. 161: 3143–3149.
- 38Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: increased mortality after γ δ T cell depletion and no effect of α β T cell depletion. Gut 2001. 48: 489–495.
- 39IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease. J. Immunol. 2002. 168: 3608–3616.
- 40IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J. Immunol. 1999. 162: 6829–6835.
- 41Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J. Immunol. 2002. 168: 411–420.
- 42Targeted disruption of IRF-1 and IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell 1993. 75: 83–90.
- 43Pulmonary inflammation induced by Pseudomonas aeuriginosa lipopolysaccharide, phospholipase C and exotoxin A: role of interferon regulatory factor 1. Infect. Immun. 2002. 70: 1352–1358.
- 44Interleukin (IL)-12-induced interferon-γ is dependent on caspase-1 processing of the IL-18 precursor. J. Clin. Invest. 1999. 104: 761–767.

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