• 1
    Herzenberg, L. A., Kantor, A. B. and Herzenberg, L. A., Layered evolution in the immune system. A model for the ontogeny and development of multiple lymphocyte lineages. Ann. N. Y. Acad. Sci. 1992. 651: 19.
  • 2
    Hardy, R. R. and Hayakawa, K., CD5 B cells, a fetal B cell lineage. Adv. Immunol. 1994. 5: 297339.
  • 3
    Kocks, C. and Rajewsky, K., Stable expression and somatic hypermutation of antibody V regions in B cell developmental pathways. Ann. Rev. Immunol. 1989. 7: 537559.
  • 4
    Casali, P. and Notkins, A. L., CD5+ B lymphocytes, polyreactive antibodies and the human B cell repertoire. Immunol. Today 1989. 10: 364368.
  • 5
    Takatsu, K., Tominaga, A., Harada, N., Mita, S., Matsumoto, M., Takahashi, T., Kikuchi, Y. and Yamaguchi, N., T cell-replacing factor (TRF)/interleukin 5 (IL-5): molecular and functional properties. Immunol. Rev. 1988. 102: 107135.
  • 6
    Hitoshi, Y., Yamaguchi, N., Mita, S., Sonoda, E., Takaki, S., Tominaga, A. and Takatsu, K., Distribution on IL-5 receptor-positive B cells. Expression of IL-5 receptor on Ly-1(CD5)+ B cells. J. Immunol. 1990. 144: 42184225.
  • 7
    Tominaga, A., Mita, S., Nishikawa, S., Ogawa, M., Hitoshi, Y., Kikuchi, Y. and Takatsu, K., Establishment of IL-5 dependent early B cell lines from bone marrow cells by long term bone marrow culture. Growth Factors 1989. 1: 135146.
  • 8
    Tominaga, A., Takaki, S., Koyama, N., Katoh, S., Matsumoto, R., Migita, M., Hitoshi, Y., Hosoya, Y., Yamaguchi, S., Kanai, Y., Miyazaki, J., Usaku, G., Yamamura, K. and Takatsu, K., Transgenic mice expressing a B cell growth and differentiation factor gene (interkeukin 5) develop eosinophilia and autoantibody production. J. Exp. Med. 1991. 173: 429437.
  • 9
    Shirai, T., Hirose, S., Okada, T. and Nishimura, H., Immunology and immunopathology of the autoimmune disease of NZB and related mouse strains. In Rihova, B. and Vetvicka, V. (Eds.) Immunological disorders in mice. CRC Press Inc., Boca Raton 1991, pp 95136.
  • 10
    Okada, T., Abe, M., Takiura, F., Hirose, S. and Shirai, T., Distinct surface phenotypes of B cells responsible for spontaneous production of IgM and IgG anti-DNA antibodies in autoimmune-prone NZB×NZW F1 mice. Autoimmunity 1990. 7: 109120.
  • 11
    Herron, L. R., Coffman, R. L., Bond, M. W. and Kotzin, B. L., Increased autoantibody production by NZB/NZW B cells in response to IL-5. J. Immunol. 1988. 141: 842848.
  • 12
    Umland, S. P., Go, N. F., Cupp, J. E. and Howard, M., Responses of B cells from autoimmune mice to IL-5. J. Immunol. 1989. 142: 15281535.
  • 13
    Kanno, K., Okada, T., Abe, M., Hirose, S. and Shirai, T., Differential sensitivity to interleukins of CD5+ and CD5 anti-DNA antibody-producing B cells in murine lupus. Autoimmunity 1993. 14: 205214.
  • 14
    Jiang, Y., Hirose, S., Hamano, Y., Kodera, S., Tsurui, H., Abe, M., Terashima, K., Ishikawa, S. and Shirai, T., Mapping of a gene for the increased susceptibility of B1 cells to Mott cell formation in murine autoimmune disease. J. Immunol. 1997. 158: 992997.
  • 15
    East, J., De Sousa, M. A. B. and Parrott, D. M. V., Immunopathology of New Zealand Black (NZB) mice. Transplantation 1965. 3: 711729.
  • 16
    Shultz, L. D., Coman, D. R., Lyons, B. L., Sidman, C. L. and Taylor, S., Development of plasmacytoid cells with Russell bodies in autoimmune “viable motheaten” mice. Am. J. Pathol. 1987. 127: 3850.
  • 17
    Taki, S., Hirose, S., Kinoshita, K., Nishimura, H., Shimamura, T., Hamuro, J. and Shirai, T., Somatically mutated IgG anti-DNA antibody clonally related to germ-line encoded IgM anti-DNA antibody. Eur. J. Immunol. 1992. 22: 987992.
  • 18
    Tillman, D. M., Jou, N.-T., Hill, R. J. and Marion, T. N., Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB×NZW) F1 mice. J. Exp. Med. 1992. 176: 761779.
  • 19
    Labrecque, N., Madsen, L., Fugger, L., Benoist, C. and Mathis, D., Toxic MHC class II β chains. Immunity 1999. 11: 515516.
  • 20
    Nishimura, H., Ishikawa, S., Nozawa, S., Awaji, M., Saito, J., Abe, M., Gotoh, Y., Tokushima, M., Kimoto, M., Akakura, S., Tsurui, H., Hirose, S. and Shirai, T., Effects of transgenic mixed-haplotype major histocompatibility complex class II molecules Aαdz on autoimmune disease in New Zealand mice. Int. Immunol. 1996. 8: 967976.
  • 21
    Hirose, S., Yan, K., Abe, M., Jiang, Y., Hamano, Y., Tsurui, H. and Shirai, T., Precursor B cells for autoantibody production in genomically Fas-intact autoimmune disease are not subject to Fas-mediated immune elimination. Proc. Natl. Acad. Sci. USA 1997. 94: 92919295.
  • 22
    Hasegawa, K., Abe, M., Okada, T., Hirose, S., Sato, H. and Shirai, T., Are Ly-1 B cells responsible for the IL2-hyperresponsiveness of B cells in autoimmune-prone NZB×NZW F1 mice? Int. Immunol. 1989. 1: 99103.
  • 23
    Sekigawa, I., Noguchi, K., Hasegawa, K., Hirose, S., Sato, H. and Shirai, T., B cell hyperresponsiveness to interleukin 2 and the age-associated decline in murine lupus. Clin. Immunol. Immunopathol. 1989. 51: 172184.
  • 24
    Satoh, S., Katagiri, T., Takaki, S., Kikuchi, Y., Hitoshi, Y., Yonehara, S., Tsukada, S., Kitamura, D., Watanabe, T., Witte, O. and Takatsu, K., IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. J. Exp. Med. 1994. 180: 21012111.
  • 25
    Yousefi, S., Hoessli, D. C., Blaser, K., Mills, G. B. and Simon, H. U., Requirement of Lyn and Syk tyrosine kinase for the prevention of apoptosis by cytokines in human eosinophils. J. Exp. Med. 1996. 183: 14071414.
  • 26
    Yasue, T., Nishizumi, H., Aizawa, S., Yamamoto, T., Miyake, K., Mizoguchi, C., Uehara, S., Kikuchi, Y. and Takatsu, K., A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5. Proc. Natl. Acad. Sci. USA 1997. 94: 1030710312.
  • 27
    Ogata, N., Kouro, T., Yamada, A., Koike, M., Hanai, N., Ishikawa, T. and Takatsu, K., Jak2 and Jak1 constitutively associate with an interleukin-5 (IL-5) receptor α and βc subunit, respectively, and are activated upon IL-5 stimulation. Blood 1998. 91: 22642271.
  • 28
    Pazdrak, K., Olszewska-Pazdrak, B., Stafford, S., Garofalo, R. P. and Alam, R., Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation. J. Exp. Med. 1998. 188: 421429.
  • 29
    Kikuchi, Y., Yasue, T., Miyake, K., Kimoto, M. and Takatsu, K., CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor α chain: synergistic effects with interleukin 5. Proc. Natl. Acad. Sci. USA 1995. 92: 1181411818.
  • 30
    Horikawa, K., Kaku, H., Nakajima, H., Davey, H. W., Henninghausen, L., Iwamoto, I., Yasue, T., Kariyone, A. and Takatsu, K., Essential role of STAT5 for IL-5-dependent IgH switch recombination in mouse B cells. J. Immunol. 2001. 167: 50185026.
  • 31
    Okada, T., Takiura, F., Tokushige, K., Nozawa, S., Kiyosawa, T., Nakauchi, H., Hirose, S. and Shirai, T., Major histocompatibility complex controls clonal proliferation of CD5+ B cells in H-2-congenic New Zealand mice: a model for B cell chronic lymphocytic leukemia and autoimmune disease. Eur. J. Immunol. 1991. 21: 27432748.
  • 32
    Shirai, T., Okada, T. and Hirose, S., Genetic regulation of CD5+ B cells in autoimmune disease and in chronic lymphocytic leukemia. Ann. N. Y. Acad. Sci. 1992. 651: 509526.
  • 33
    Hamano, Y., Hirose, S., Ida, A., Abe, M., Zhang, D., Kodera, S., Jiang, Y., Shirai, J., Miura, Y., Nishimura, H. and Shirai, T., Susceptibility alleles for aberrant B-1 cell proliferation involved in spontaneously occurring B cell chronic lymphocytic leukemia in a model of New Zealand White mice. Blood 1998. 92: 37723779.
  • 34
    Hirose, S., Jiang, Y., Hamano, Y. and Shirai, T., Genetic aspects of inherent B cell abnormalities associated with SLE and B cell malignancy: lessons from New Zealand mouse models. Int. Rev. Immunol. 2000. 19: 389421.
  • 35
    Li, N., Nakamura, K., Jiang, Y., Tsurui, H., Matsuoka, S., Abe, M., Ohtsuji, M., Nishimura, H., Kato, K., Kawai, T., Atsumi, T., Koike, T., Shirai, T., Ueno, H. and Hirose, S., Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum. Mol. Genet. 2004. 13: 171179.
  • 36
    Conley, C. L., Misiti, J. and Laster, A. J., Genetic factors predisposing to chronic lymphocytic leukemia and to autoimmune disease. Medicine 1980. 59: 323334.
  • 37
    Hirose, S., Nagasawa, R., Sekikawa, I., Hamaoki, M., Ishida, Y., Sato, H. and Shirai, T., Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB×NZW) F1 mice. J. Exp. Med. 1983. 158: 228233.
  • 38
    Hirose, S., Ueda, G., Noguchi, K., Okada, T., Sekigawa, I., Sato, H. and Shirai, T., Requirement of H-2 heterozygosity for autoimmunity in (NZB×NZW) F1 hybrid mice. Eur. J. Immunol. 1986. 16: 16311633.
  • 39
    Hirose, S., Kinoshita, K., Nozawa, S., Nishimura, H. and Shirai, T., Effects of major histocompatibility complex on autoimmune disease of H-2-congenic New Zealand mice. Int. Immunol. 1990. 2: 10911095.
  • 40
    Tominaga, A., Matsumoto, M., Harada, N., Takahashi, T., Kikuchi, Y. and Takatsu, K., Molecular properties and regulation of mRNA expression for murine T cell-replacing factor (TRF)/IL-5. J. Immunol. 1988. 140: 11751181.
  • 41
    Yamaguchi, N., Hitoshi, Y., Mita, S., Hosoya, Y., Murata, Y., Kikuchi, Y., Tominaga, A. and Takatsu, K., Characterization of the murine interleukin 5 receptor by using a monoclonal antibody. Int. Immunol. 1990. 2: 181187.
  • 42
    Stall, A. M., Farinas, M. C., Tarlington, D. M., Lalor, P. A., Herzenberg, L. A., Strober, S. and Herzenberg, L. A., Ly-1 B cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Proc. Natl. Acad. Sci. USA 1988. 85: 73127316.