• 1
    Caplan, A., Mesenchymal stem cells. J. Orthop. Res. 1991. 9: 641650.
  • 2
    Bianco, P., Riminucci, M., Gronthos, S. and Robey, P., Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001. 19: 180192.
  • 3
    Caplan, A., In vivo remodeling. Ann. N. Y. Acad. Sci. 2002. 961: 307308.
  • 4
    Quarto, R., Mastrogiacomo, M., Cancedda, R., Kutepov, S., Mukhachev, V., Lavroukov, A., Kon, E. and Marcacci, M., Repair of large bone defects with the use of autologous bone marrow stromal cells. N. Engl. J. Med. 2001. 344: 385386.
  • 5
    Horwitz, E., Prockop, D., Fitzpatrick, L., Koo, W., Gordon, P., Neel, M., Sussman, M., Orchard, P., Marx, J., Pyeritz, R. and Brenner, M., Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat. Med. 1999. 5: 309313.
  • 6
    Ishida, T., Inaba, M., Hisha, H., Sugiura, K., Adachi, Y., Nagata, N., Ogawa, R., Good, R. and Ikehara, S., Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. Complete prevention of recurrence of autoimmune diseases in MRL/MP-Ipr/Ipr mice by transplantation of bone marrow plus bones (stromal cells) from the same donor. J. Immunol. 1994. 152: 31193127.
  • 7
    Ikehara, S., Successful allogeneic bone marrow transplantation. Crucial roles of stromal cells in prevention of graft rejection. Acta Haematol 2001. 105: 172178.
  • 8
    Maitra, B., Szekely, E., Gjini, K., Laughlin, M., Dennis, J., Haynesworth, S. and Koç1, O., Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T cell activation. Bone Marrow Transplant. 2004. 33: 597604.
  • 9
    Le Blanc, K., Rasmusson, I., Sundberg, B., Gotherstrom, C., Hassan, M., Uzunel, M. and Ringden, O., Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004. 363: 14391441.
  • 10
    Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., Longoni, P., Matteucci, P., Grisanti, S. and Gianni, A., Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002. 99: 38383843.
  • 11
    Krampera, M., Glennie, S., Dyson, J., Scott, D., Laylor, R., Simpson, E. and Dazzi, F., Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003. 101: 37223729.
  • 12
    Potian, J., Aviv, H., Ponzio, N., Harrison, J. and Rameshwar, P., Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J. Immunol. 2003. 171: 34263434.
  • 13
    Ozkaynak, E., Wang, L., Goodearl, A., McDonald, K., Qin, S., O'Keefe, T., Duong, T., Smith, T., Gutierrez-Ramos, J., Rottman, J. et al., Programmed death-1 targeting can promote allograft survival. J. Immunol. 2002. 169: 65466553.
  • 14
    Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D., Okumura, K. et al., Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 2002. 169: 55385545.
  • 15
    Gao, W., Demirci, G., Strom, T. and Li, X., Stimulating PD-1 negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival. Transplantation 2003. 76: 994999.
  • 16
    Freeman, G., Long, A., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L., Malenkovich, N., Okazaki, T., Byrne, M. et al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000. 192: 10271034.
  • 17
    Latchman, Y., Wood, C., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A., Brown, J., Nunes, R. et al., PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2001. 2: 261268.
  • 18
    Khaled, A. and Durum, S., Lymphocide: cytokines and the control of lymphoid homeostasis. Nat. Rev. Immunol. 2002. 2: 817830.
  • 19
    McKarns, S., Schwartz, R. and Kaminski, N., Smad3 is essential for TGF-beta1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation. J. Immunol. 2004. 172: 42754284.
  • 20
    Groux, H. and Cottrez, F., The complex role of interleukin-10 in autoimmunity. J. Autoimmun. 2003. 20: 281285.
  • 21
    Cooke, K. and Ferrara, J., A protective gene for graft-versus-host disease. N. Engl. J. Med. 2003. 349: 21832184.
  • 22
    Kuznetsov, S., Mankani, M., Gronthos, S., Satomura, K., Bianco, P. and Robey, P., Circulating skeletal stem cells. J. Cell Biol 2001. 153: 11331139.
  • 23
    Jiang, Y., Jahagirdar, B., Reinhardt, R., Schwartz, R., Keenek, C., Ortiz-Gonzalezk, X., Reyes, M., Lenvik, T., Lund, T., Blackstad, M. et al., Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002. 418: 4149.
  • 24
    Peister, A., Mellad, J., Larson, B., Hall, B., Gibson, L. and Prockop, D., Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 2004. 103: 16621668.
  • 25
    Probst, H., McCoy, K., Okazaki, T., Honjo, T. and van den Broek, M., Resting dendritic cells induce peripheral CD8(+) T cell tolerance through PD-1 and CTLA-4. Nat. Immunol. 2005. 6: 280286.
  • 26
    Rodig, N., Ryan, T., Allen, J., Pang, H., Grabie, N., Chernova, T., Greenfield, E., Liang, S., Sharpe, A., Lichtman, A. and Freeman, G., Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur. J. Immunol. 2003. 33: 31173126.
  • 27
    Hori, J., Ng, T., Shatos, M., Klassen, H., Streilein, J. and Young, M., Neural progenitor cells lack immunogenicity and resist destruction as allografts. Stem Cells 2003. 21: 405416.
  • 28
    Nelson, B., Martyak, T., Thompson, L., Moon, J. and Wang, T., Uncoupling of promitogenic and antiapoptotic functions of IL-2 by Smad-dependent TGF-beta signaling. J. Immunol. 2003. 170: 55635570.
  • 29
    Kelly, J., Spolski, R., Imada, K., Bollenbacher, J., Lee, S. and Leonard, W., A role for Stat5 in CD8+ T cell homeostasis. J. Immunol. 2003. 170: 210217.
  • 30
    Levings, M., Sangregorio, R., Sartirana, C., Moschin, A., Battaglia, M., Orban, P. and Roncarolo, M., Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 2002. 196: 13351346.
  • 31
    Zheng, S., Wang, J., Koss, M., Quismorio, F., Dixon Gray, J. and Horwitz, D., CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-β suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J. Immunol. 2004. 172: 15311539.
  • 32
    Aramaki, O., Shirasugi, N., Takayama, T., Shimazu, M., Kitajima, M., Ikeda, Y., Azuma, M., Okumura, K., Yagita, H. and Niimi, M., Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen. Transplantation 2004. 77: 612.