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    Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., Mattson, M. P., Flavell, R. A. and Mullan, M., Microglial activation resulting from CD40-CD40L interaction after β-amyloid stimulation. Science 1999. 286: 23522355.
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    Tan, J., Town, T., Crawford, F., Mori, T., DelleDonne, A., Crescentini, R., Obregon, D., Flavell, R. A. and Mullan, M. J., Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat. Neurosci. 2002. 5: 12881293.
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    Kikuchi, T., Worgall, S., Singh, R., Moore, M. A. and Crystal, R.G., Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells. Nat. Med. 2000. 6: 11541159.
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    McLellan, A., Heldmann, M., Terbeck, G., Weih, F., Linden, C., Brocker, E. B., Leverkus, M. and Kampgen, E., MHC class II and CD40 play opposing roles in dendritic cell survival. Eur. J. Immunol. 2000. 30: 26122619.
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    Bard, F., Cannon, C., Barbour, R., Burke, R. L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K. et al., Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 2000. 8: 916919.
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    Matyszak, M. K., Denis-Donini, S., Citterio, S., Longhi, R., Granucci, F. and Ricciardi-Castagnoli, P., Microglia induce myelin basic protein-specific T cell anergy or T cell activation, according to their state of activation. Eur. J. Immunol. 1999. 29: 30633076.
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    Aloisi, F., De Simone, R., Columba-Cabezas, S., Penna, G. and Adorini, L., Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells. J. Immunol. 2000. 164: 17051712.
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    Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J. and Landreth, G. E., A cell surface receptor complex for fibrillar β-amyloid mediates microglial activation. J. Neurosci. 2003. 23: 26652674.
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    Koenigsknecht, J. and Landreth, G., Microglial phagocytosis of fibrillar β-amyloid through a β1 integrin-dependent mechanism. J. Neurosci. 2004. 24: 98389846.
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    Ferrer, I., Boada Rovira, M., Sanchez Guerra, M. L., Rey, M. J. and Costa-Jussa, F., Neuropathology and pathogenesis of encephalitis following amyloid-β immunization in Alzheimer's disease. Brain Pathol. 2004. 14: 1120.
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    Becker, T., Hartl, F. U. and Wieland, F., CD40, an extracellular receptor for binding and uptake of HSP70-peptide complexes. J. Cell Biol. 2002. 158: 12771285.
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    Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke-Haerter, P. J., Smith, M. A. et al., Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. FASEB J. 2002. 16: 601603.
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    Tan, J., Town, T. and Mullan, M., CD45 inhibits CD40L-induced microglial activation via negative regulation of the Src/p44/42 MAPK pathway. J. Biol. Chem. 2000. 275: 3722437231.
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    Mitrasinovic, O. M. and Murphy, G. M., Jr., Accelerated phagocytosis of amyloid-β by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. J. Biol. Chem. 2002. 277: 2988929896.
  • 40
    Tan, J., Town, T., Paris, D., Placzek, A., Parker, T., Crawford, F., Yu, H., Humphrey, J. and Mullan, M., Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis. J. Neuroimmunol. 1999. 97: 7785.
  • 41
    Town, T., Vendrame, M., Patel, A., Poetter, D., DelleDonne, A., Mori, T., Smeed, R., Crawford, F., Klein, T., Tan, J. et al., Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's β-amyloid (1–42). J. Neuroimmunol. 2002. 132: 4959.