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  • 1
    Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J. and Waterfield, M. D., Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 2001. 70: 535602.
  • 2
    Wymann, M. P., Zvelebil, M. and Laffargue, M., Phosphoinositide 3-kinase signalling – which way to target? Trends Pharmacol. Sci. 2003. 24: 366376.
  • 3
    Sawyer, C., Sturge, J., Bennett, D. C., O'Hare, M. J., Allen, W. E., Bain, J., Jones, G. E. and Vanhaesebroeck, B., Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110 delta. Cancer Res. 2003. 63: 16671675.
  • 4
    Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtchenkov, M., Malek, D., Stoyanova, S., Vanhaesebroeck, B., Dhand, R. and Nurnberg, B., Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 1995. 269: 690693.
  • 5
    Stephens, L. R., Eguinoa, A., Erdjment-Bromage, H., Lui, M., Cooke, F., Coadwell, J., Smrcka, A. S., Thelen, M., Cadwallader, K., Tempst, P. and Hawkins, P. T., The Gbetagamma/sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 1997. 89: 105114.
  • 6
    Arcaro, A. and Wymann, M. P., Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 1993. 296: 297301.
  • 7
    Hannigan, M., Zhan, L., Li, Z., Ai, Y., Wu, D. and Huang, C. K., Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc. Natl. Acad. Sci. USA 2002. 99: 36033608.
  • 8
    Tigani, B., Hannon, J. P., Mazzoni, L. and Fozard, J. R., Effects of wortmannin on airways inflammation induced by allergen in actively sensitised Brown Norway rats. Eur. J. Pharmacol. 2001. 433: 217223.
  • 9
    Cozier, G. E., Carlton, J., Bouyoucef, D. and Cullen, P. J., Membrane targeting by pleckstrin homology domains. Curr. Top. Microbiol. Immunol. 2004. 282: 4988.
  • 10
    Cantley, L. C., The phosphoinositide 3-kinase pathway. Science 2002. 296: 16551657.
  • 11
    Welch, H. C. E., Coadwell, W. J., Ellson, C. D., Ferguson, G. J., Andrews, S. R., Erdjument-Bromage, H., Tempst, P., Hawkins, P. T. and Stephens, L. R., P-Rex1, a PtdIns(3,4,5)P-3- and G beta gamma-regulated guanine-nucleotide exchange factor for Rac. Cell 2002. 108: 809821.
  • 12
    Geijsen, N., van Delft, S., Raaijmakers, J. A., Lammers, J. W., Collard, J. G., Koenderman, L. and Coffer, P. J., Regulation of p21rac activation in human neutrophils. Blood 1999. 94: 11211130.
  • 13
    Foukas, L. C. and Okkenhaug, K., Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases. Arch. Biochem. Biophys. 2003. 414: 1318.
  • 14
    Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., Pearce, W., Meek, S. E., Salpekar, A., Waterfield, M. D., Smith, A. J. H. and Vanhaesebroeck, B., Impaired B and T cell antigen receptor signaling in p110 delta PI 3-kinase mutant mice. Science 2002. 297: 10311034.
  • 15
    Clayton, E., Bardi, G., Bell, S. E., Chantry, D., Downes, C. P., Gray, A., Humphries, L. A., Rawlings, D., Reynolds, H., Vigorito, E. and Turner, M., A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 2002. 196: 753763.
  • 16
    Jou, S. T., Carpino, N., Takahashi, Y., Piekorz, R., Chao, J. R., Carpino, N., Wang, D. and Ihle, J. N., Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B cell receptor complex. Mol. Cell. Biol. 2002. 22: 85808591.
  • 17
    Hirsch, E., Katanaev, V. L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F. and Wymann, M. P., Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 2000. 287: 10491052.
  • 18
    Sasaki, T., Irie-Sasaki, J., Jones, R. G., Oliveira-dos-Santos, A. J., Stanford, W. L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I. et al., Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 2000. 287: 10404046.
  • 19
    Laffargue, M., Calvez, R., Finan, P., Trifilieff, A., Barbier, M., Altruda, F., Hirsch, E. and Wymann, M. P., Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity 2002. 16: 441451.
  • 20
    Hirsch, E., Bosco, O., Tropel, P., Laffargue, M., Calvez, R., Altruda, F., Wymann, M. P. and Montrucchio, G., Resistance to thromboembolism in PI3K gamma-deficient mice. FASEB J. 2001. 15: 20192021.
  • 21
    Crackower, M. A., Oudit, G. Y., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Hirsch, E., Suzuki, A., Shioi, T., Irie-Sasaki, J. et al., Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002. 110: 737749.
  • 22
    Xu, J., Wang, F., Van Keymeulen, A., Herzmark, P., Straight, A., Kelly, K., Takuwa, Y., Sugimoto, N., Mitchison, T. and Bourne, H. R., Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 2003. 114: 201214.
  • 23
    Heit, B., Tavener, S., Raharjo, E. and Kubes, P., An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J. Cell Biol. 2002. 159: 91102.
  • 24
    Barnes, P. J., Chronic obstructive pulmonary disease: 12: New treatments for COPD. Thorax 2003. 58: 803808.
  • 25
    Chollet-Martin, S., Jourdain, B., Gibert, C., Elbim, C., Chastre, J. and Pocidalo, M. A., Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. Am. J. Respir. Crit. Care Med. 1996. 154: 594601.
  • 26
    Yum, H. K., Arcaroli, J., Kupfner, J., Shenkar, R., Penninger, J. M., Sasaki, T., Yang, K. Y., Park, J. S. and Abraham, E., Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J. Immunol. 2001. 167: 66016608.
  • 27
    Oppenheim, J. J., Matsushima, K., Yoshimura, T., Leonard, E. J. and Neta, R., Relationship between interleukin 1 (IL1), tumor necrosis factor (TNF) and a neutrophil attracting peptide (NAP-1). Agents Actions 1989. 26: 134140.
  • 28
    Haskill, S., Peace, A., Morris, J., Sporn, S. A., Anisowicz, A., Lee, S. W., Smith, T., Martin, G., Ralph, P. and Sager, R., Identification of three related human GRO genes encoding cytokine functions. Proc. Natl. Acad. Sci. USA 1990. 87: 77327736.
  • 29
    Ulich, T. R., Yin, S., Guo, K., Del Castillo, J., Eisenberg, S. P. and Thompson, R. C., The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation. Am. J. Pathol. 1991. 138: 521524.
  • 30
    Sadhu, C., Masinovsky, B., Dick, K., Sowell, C. G. and Staunton, D. E., Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J. Immunol. 2003. 170: 26472654.
  • 31
    Li, Z., Hannigan, M., Mo, Z. C., Liu, B., Lu, W., Wu, Y., Smrcka, A. V., Wu, G. Q., Li, L., Liu, M. Y., Huang, C. K. and Wu, D. Q., Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of cdc42. Cell 2003. 114: 215227.
  • 32
    Jones, G. E., Prigmore, E., Calvez, R., Hogan, C., Dunn, G. A., Hirsch, E., Wymann, M. P. and Ridley, A. J., Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1. Exp. Cell Res. 2003. 290: 120131.
  • 33
    Sadhu, C., Dick, K., Tino, W. T. and Staunton, D. E., Selective role of PI3Kdelta in neutrophil inflammatory responses. Biochem. Biophys. Res. Comm. 2003. 308: 764769.
  • 34
    Puri, K. D., Doggett, T. A., Douangpanya, J., Hou, Y., Tino, W. T., Wilson, T., Graf, T., Clayton, E., Turner, M., Hayflick, J. S. and Diacovo, T. G., Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Blood 103: 34483456.
  • 35
    Wymann, M. P., Bulgarelli-Leva, G., Zvelebil, M. J., Pirola, L., Vanhaesebroeck, B., Waterfield, M. D. and Panayotou, G., Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol. Cell. Biol. 1996. 16: 17221733.
  • 36
    Baggiolini, M. and Wymann, M. P., Turning on the respiratory burst. Trends Biochem. Sci. 1990. 15: 6972.
  • 37
    Barker, S. A., Caldwell, K. K., Hall, A., Martinez, A. M., Pfeiffer, J. R., Oliver, J. M. and Wilson, B. S., Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by FcepsilonR1 cross-linking. Mol. Biol. Cell 1995. 6: 11451158.
  • 38
    Turner, L., Ward, S. G. and Westwick, J., A role for phosphoinositide 3-kinase in RANTES induced chemotaxis of T lymphocytes. Biochem. Soc. Trans. 1995. 23: 283S.
  • 39
    Walker, E. H., Pacold, M. E., Perisic, O., Stephens, L., Hawkins, P. T., Wymann, M. P. and Williams, R. L., Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol. Cell 2000. 6: 909919.
  • 40
    Reif, K., Okkenhaug, K., Sasaki, T., Penninger, J. M., Vanhaesebroeck, B. and Cyster, J. G., Cutting edge: Differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J. Immunol. 173: 22362240.
  • 41
    Curnock, A. P., Sotsios, Y., Wright, K. L. and Ward, S. G., Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class IA and IB phosphoinositide 3-kinases. J. Immunol. 170: 40214030.
  • 42
    Chodniewicz, D. and Zhelev, D. V., Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by two distinct pathways. Blood 2003. 101: 11811184.
  • 43
    Chodniewicz, D. and Zhelev, D. V., Novel pathways of F-actin polymerization in the human neutrophil. Blood 2003
  • 44
    Akasaki, T., Koga, H. and Sumimoto, H., Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. J. Biol. Chem. 1999. 274: 1805518059.
  • 45
    Domin, J., Pages, F., Volinia, S., Rittenhouse, S. E., Zvelebil, M. J., Stein, R. C. and Waterfield, M. D., Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 1997. 326: 139147.
  • 46
    Nakanishi, S., Kakita, S., Takahashi, I., Kawahara, K., Tsukuda, E., Sano, T., Yamada, K., Yoshida, M., Kase, H. and Matsuda, Y., Wortmannin, a microbial product inhibitor of myosin light chain kinase. J. Biol. Chem. 1992. 267: 21572163.