• 1
    Kono, D. H. and Theofilopoulos, A. N., Genetics of systemic autoimmunity in mouse models of lupus. Int. Rev. Immunol. 2000. 19: 367387.
  • 2
    Watson, M. L., Rao, J. K., Gilkeson, G. S., Ruiz, P., Eicher, E. M., Pisetsky, D. S., Matsuzawa, A., Rochelle, J. M. and Seldin, M. F., Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 1992. 176: 16451656.
  • 3
    Vidal, S., Kono, D. H. and Theofilopoulos, A. N., Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice. J. Clin. Invest. 1998. 101: 696702.
  • 4
    Hogarth, M. B., Slingsby, J. H., Allen, P. J., Thompson, E. M., Chandler, P., Davies, K. A., Simpson, E., Morley, B. J. and Walport, M. J., Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice. J. Immunol. 1998. 161: 27532761.
  • 5
    Morel, L., Rudofsky, U. H., Longmate, J. A., Schiffenbauer, J. and Wakeland, E. K., Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1994. 1: 219229.
  • 6
    Kono, D. H., Park, M. S. and Theofilopoulos, A. N., Genetic complementation in female (BXSB × NZW)F2 mice. J. Immunol. 2003. 171: 64426447.
  • 7
    Lander, E. and Kruglyak, L., Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 1995. 11: 241247.
  • 8
    Qu, W. M., Miyazaki, T., Terada, M., Lu, L. M., Nishihara, M., Yamada, A., Mori, S., Nakamura, Y., Ogasawara, H., Yazawa, C. et al., Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele. Eur. J. Immunol. 2000. 30: 20272037.
  • 9
    Ono, M., Yamamoto, T. and Nose, M., Allelic difference in the nucleotide sequence of the Eta-1/Op gene transcript. Mol. Immunol. 1995. 32: 447448.
  • 10
    Weber, G. F., Differential roles of osteopontin/Eta-1 in early and late lpr disease. Clin. Exp. Immunol. 2001. 126: 578583.
  • 11
    Takahashi, S., Itoh, J., Nose, M., Ono, M., Yamamoto, T. and Kyogoku, M., Cloning and cDNA sequence analysis of nephritogenic monoclonal antibodies derived from an MRL/lpr lupus mouse. Mol. Immunol. 1993. 30: 177182.
  • 12
    Wang, Y., Nose, M., Kamoto, T., Nishimura, M. and Hiai, H., Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am. J. Pathol. 1997. 151: 17911798.
  • 13
    Mouse Genome Informatics. T.J.L. Mouse Genome Database (MGD). World Wide Web (URL: Bar Harbor, Maine. 2005
  • 14
    Giachelli, C. M., Lombardi, D., Johnson, R. J., Murry, C. E. and Almeida, M., Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am. J. Pathol. 1998. 152: 353358.
  • 15
    Patarca, R., Freeman, G. J., Singh, R. P., Wei, F. Y., Durfee, T., Blattner, F., Regnier, D. C., Kozak, C. A., Mock, B. A., Morse III, H. C. et al., Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection. J. Exp. Med. 1989. 170: 145161.
  • 16
    Patarca, R., Wei, F. Y., Singh, P., Morasso, M. I. and Cantor, H., Dysregulated expression of the T cell cytokine Eta-1 in CD4-8-lymphocytes during the development of murine autoimmune disease. J. Exp. Med. 1990. 172: 11771183.
  • 17
    Haywood, M. E., Hogarth, M. B., Slingsby, J. H., Rose, S. J., Allen, P. J., Thompson, E. M., Maibaum, M. A., Chandler, P., Davies, K. A., Simpson, E. et al., Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis Rheum. 2000. 43: 349355.
  • 18
    Ibnou-Zekri, N., Iwamoto, M., Gershwin, M. E. and Izui, S., Protection of murine lupus by the Ead transgene is MHC haplotype-dependent. J. Immunol. 2000. 164: 505511.
  • 19
    Roper, R. J., Weis, J. J., McCracken, B. A., Green, C. B., Ma, Y., Weber, K. S., Fairbairn, D., Butterfield, R. J., Potter, M. R., Zachary, J. F. et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Infect. Immun. 2000. 68: 388397.
  • 20
    Karlsson, J., Zhao, X., Lonskaya, I., Neptin, M., Holmdahl, R. and Andersson, A., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J. Immunol. 2002. 420: 10191026.
  • 21
    Potter, M. R., Rittling, S. R., Denhardt, D. T., Roper, R. J., Weis, J. H., Teuscher, C. and Weis, J. J., Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi. Infect. Immun. 2002. 70: 13721381.
  • 22
    Chabas, D., The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 2001. 294: 17311735.
  • 23
    Blom, T., Franzen, A., Heinegard, D. and Holmdahl, R., The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 2003. 299: 1845.
  • 24
    Steinman, L., Youssef, S., Van Venrooji, N., Chabas, D., Baranzini, S. E., Rittling, S., Denhardt, D., Sobel, R. A., Lock, C., Pedotti, R. and Oksenberg, J. R., Response to comment on ”The influence of the proinflammatory cytokine, osteoontin, on autoimmune demyelinating disease“. Science 2003. 299: 1845.
  • 25
    Jansson, M., Panoutsakopoulou, V., Baker, J., Klein, L. and Cantor, H., Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J. Immunol. 2002. 168: 20962099.
  • 26
    Caillier, S., Barcellos, L. F., Baranzini, S. E., Swerdlin, A., Lincoln, R. R., Steinman, L., Martin, E., Haines, J. L., Pericak-Vance, M., Hauser, S. L. and Oksenberg, J. R., Osteopontin polymorphisms and disease course in multiple sclerosis. Genes. Immun. 2003. 4: 312315.
  • 27
    Comabella, M., Pericot, I., Goertsches, R., Nos, C., Castillo, M., Blas Navarro, J., Rio, J. and Montalban, X., Plasma osteopontin levels in multiple sclerosis. J. Neuroimmunol. 2005. 158: 231239.
  • 28
    Yu, X. Q., Nikolic Paterson, D. J., Mu, W., Giachelli, C. M., Atkins, R. C., Johnson, R. J. and Lan, H. Y., A functional role for osteopontin in experimental crescentic glomerulonephritis in the rat. Proc. Assoc. Am. Physicians 1998. 110: 5064.
  • 29
    Hudkins, K. L., Giachelli, C. M., Eitner, F., Couser, W. G., Johnson, R. J. and Alpers, C. E., Osteopontin expression in human crescentic glomerulonephritis. Kidney Int. 2000. 57: 105116.
  • 30
    Sibalic, V., Fan, X., Loffing, J. and Wuthrich, R. P., Upregulated renal tubular CD44, hyaluronan, and osteopontin in kdkd mice with interstitial nephritis. Nephrol. Dial. Transplant. 1997. 12: 13441353.
  • 31
    Petrow, P. K., Hummel, K. M., Schedel, J., Franz, J. K., Klein, C. L., Muller-Ladner, U., Kriegsmann, J., Chang, P. L., Prince, C. W., Gay, R. E. and Gay, S., Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts. Arthritis Rheum. 2000. 43: 15971605.
  • 32
    Nakama, K., Miyazaki, Y. and Nasu, M., Immunophenotyping of lymphocytes in the lung interstitium and expression of osteopontin and interleukin-2 mRNAs in two different murine models of pulmonary fibrosis. Exp. Lung Res. 1998. 24: 5770.
  • 33
    Giacopelli, F., Marciano, R., Pistorio, A., Catarsi, P., Canini, S., Karsenty, G. and Ravazzolo, R., Polymorphisms in the osteopontin promoter affect its transcriptional activity. Physiol. Genomics 2004. 20: 8796.
  • 34
    Aherrahrou, Z., Axtner, S. B., Kaczmarek, P. M., Jurat, A., Korff, S., Doehring, L. C., Weichenhan, D., Katus, H. A. and Ivandic, B. T., A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. Am. J. Pathol. 2004. 164: 13791387.
  • 35
    Tanaka, K., Morimoto, J., Kon, S., Kimura, C., Inobe, M., Diao, H., Hirschfeld, G., Weiss, J. M. and Uede, T., Effect of osteopontin alleles on beta-glucan-induced granuloma formation in the mouse liver. Am. J. Pathol. 2004. 164: 567575.
  • 36
    Hu, D. D., Lin, E. C., Kovach, N. L., Hoyer, J. R. and Smith, J. W., A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5. J. Biol. Chem. 1995. 270: 2623226238.
  • 37
    Caltabiano, S., Hum, W. T., Attwell, G. J., Gralnick, D. N., Budman, L. J., Cannistraci, A. M. and Bex, F. J., The integrin specificity of human recombinant osteopontin. Biochem. Pharmacol. 1999. 58: 15671578.
  • 38
    Corjay, M. H., Diamond, S. M., Schlingmann, K. L., Gibbs, S. K., Stoltenborg, J. K. and Racanelli, A. L., Alphavbeta3, alphavbeta5, and osteopontin are coordinately upregulated at early time points in a rabbit model of neointima formation. J. Cell. Biochem. 1999. 75: 492504.
  • 39
    Patarca, R., Saavedra, R. A. and Cantor, H., Molecular and cellular basis of genetic resistance to bacterial infection: the role of the early T-lymphocyte activation-1/osteopontin gene. Crit. Rev. Immunol. 1993. 13: 225246.
  • 40
    Lander, E. S., Green, P., Abrahamson, J., Barlow, A., Daly, M. J., Lincoln, S. E. and Newburg, L., MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1987. 1: 174181.
  • 41
    Basten, J. C., Gaffney, P., Wang, S. and Zeng, Z. B., Windows QTL Cartographer Version 2.0. Statistical Genetics, North Carolina State University, Raleigh, NC. 2003.
  • 42
    Nettleton, D. and Doerge, R. W., Accounting for variability in the use of permutation testing to detect quantitative trait loci. Biometrics 2000. 56: 5258.
  • 43
    Schmittgen, T. D., Zakrajsek, B. A., Mills, A. G., Gorn, V., Singer, M. J. and Reed, M. W., Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal. Biochem. 2000. 285: 194204.
  • 44
    Madin, K., Sawasaki, T., Ogasawara, T. and Endo, Y., A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: plants apparently contain a suicide system directed at ribosomes. Proc. Natl. Acad. Sci. USA 2000. 97: 559564.
  • 45
    Overbergh, L., Valckx, D., Waer, M. and Mathieu, C., Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 1999. 11: 305312.