SEARCH

SEARCH BY CITATION

  • 1
    Brigl, M. and Brenner, M. B., CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 2004. 22: 817890.
  • 2
    Bendelac, A., Rivera, M. N., Park, S. H. and Roark, J. H., Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 1997. 15: 535562.
  • 3
    Godfrey, D. I., Hammond, K. J., Poulton, L. D., Smyth, M. J. and Baxter, A. G., NKT cells: facts, functions and fallacies. Immunol. Today 2000. 21: 573583.
  • 4
    Exley, M., Garcia, J., Balk, S. P. and Porcelli, S., Requirements for CD1d recognition by human invariant Valpha24+ CD4CD8 T cells. J. Exp. Med. 1997. 186: 109120.
  • 5
    Biron, C. A. and Brossay, L., NK cells and NKT cells in innate defense against viral infections. Curr. Opin. Immunol. 2001. 13: 458464.
  • 6
    Norris, S., Doherty, D. G., Collins, C., McEntee, G., Traynor, O., Hegarty, J. E. and O'Farrelly, C., Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells. Hum. Immunol. 1999. 60: 2031.
  • 7
    Ishihara, S., Nieda, M., Kitayama, J., Osada, T., Yabe, T., Ishikawa, Y., Nagawa, H. et al., CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. Eur. J. Immunol. 1999. 29: 24062413.
  • 8
    Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H. et al., CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 1997. 278: 16261629.
  • 9
    Spada, F. M., Koezuka, Y. and Porcelli, S. A., CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J. Exp. Med. 1998. 188: 15291534.
  • 10
    Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P. and Kronenberg, M., CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J. Exp. Med. 1998. 188: 15211528.
  • 11
    Kobayashi, M. K., Uchida, T., Fukushima, H. and Koezuka, Y., KRN 7000, a novel immunomodulator, and its antitumor activities. Oncol. Res. 1995. 7: 529534.
  • 12
    Natori, T., Akimoto, K., Motoki, K., Koezuka, Y. and Higa, T., [Development of KRN7000, derived from agelasphin produced by Okinawan sponge]. Nippon Yakurigaku Zasshi 1997. 110 Suppl 1: 63P–68P.
  • 13
    Watanabe, K., Matsubara, T. and Hakomori, S., alpha-l-Fucopyranosylceramide, a novel glycolipid accumulated in some of the human colon tumors. J. Biol. Chem. 1976. 251: 23852387.
  • 14
    Carnaud, C., Lee, D., Donnars, O., Park, S. H., Beavis, A., Koezuka, Y. and Bendelac, A., Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 1999. 163: 46474650.
  • 15
    Ishikawa, H., Hisaeda, H., Taniguchi, M., Nakayama, T., Sakai, T., Maekawa, Y., Nakano, Y. et al., CD4(+) v(alpha)14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major. Int. Immunol. 2000. 12: 12671274.
  • 16
    Duthie, M. S., Wleklinski-Lee, M., Smith, S., Nakayama, T., Taniguchi, M. and Kahn, S. J., During Trypanosoma cruzi infection CD1d-restricted NK T cells limit parasitemia and augment the antibody response to a glycophosphoinositol-modified surface protein. Infect. Immun. 2002. 70: 3648.
  • 17
    Kumar, H., Belperron, A., Barthold, S. W. and Bockenstedt, L. K., Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi. J. Immunol. 2000. 165: 47974801.
  • 18
    Kawakami, K., Kinjo, Y., Uezu, K., Yara, S., Miyagi, K., Koguchi, Y., Nakayama, T. et al., Monocyte chemoattractant protein-1-dependent increase of V alpha 14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection. J. Immunol. 2001. 167: 65256532.
  • 19
    Exley, M. A., Bigley, N. J., Cheng, O., Tahir, S. M., Smiley, S. T., Carter, Q. L., Stills, H. F. et al., CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus. J. Leukoc. Biol. 2001. 69: 713718.
  • 20
    Johnson, T. R., Hong, S., Van Kaer, L., Koezuka, Y. and Graham, B. S., NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus. J. Virol. 2002. 76: 42944303.
  • 21
    Apostolou, I., Takahama, Y., Belmant, C., Kawano, T., Huerre, M., Marchal, G., Cui, J. et al., Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls. Proc. Natl. Acad. Sci. USA 1999. 96: 51415146.
  • 22
    Smyth, M. J., Thia, K. Y., Street, S. E., Cretney, E., Trapani, J. A., Taniguchi, M., Kawano, T. et al., Differential tumor surveillance by natural killer (NK) and NKT cells. J. Exp. Med. 2000. 191: 661668.
  • 23
    Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y. et al., Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 1997. 278: 16231626.
  • 24
    Takeda, K., Hayakawa, Y., Atsuta, M., Hong, S., Van Kaer, L., Kobayashi, K., Ito, M. et al., Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12. Int. Immunol. 2000. 12: 909914.
  • 25
    Laloux, V., Beaudoin, L., Jeske, D., Carnaud, C. and Lehuen, A., NK T cell-induced protection against diabetes in V alpha 14-J alpha 281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen. J. Immunol. 2001. 166: 37493756.
  • 26
    Wang, B., Geng, Y. B. and Wang, C. R., CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 2001. 194: 313320.
  • 27
    Shi, F. D., Flodstrom, M., Balasa, B., Kim, S. H., Van Gunst, K., Strominger, J. L., Wilson, S. B. and Sarvetnick, N., Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 2001. 98: 67776782.
  • 28
    Gonzalez-Aseguinolaza, G., Van Kaer, L., Bergmann, C. C., Wilson, J. M., Schmieg, J., Kronenberg, M., Nakayama, T. et al., Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 2002. 195: 617624.
  • 29
    Giaccone, G., Punt, C. J., Ando, Y., Ruijter, R., Nishi, N., Peters, M., Von Blomberg, B. M. et al., A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors. Clin. Cancer Res. 2002. 8: 37023709.
  • 30
    Klinman, D. M., Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 2004. 4: 249258.
  • 31
    Krieg, A. M., Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides. Curr. Oncol. Rep. 2004. 6: 8895.
  • 32
    Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M. et al., A Toll-like receptor recognizes bacterial DNA. Nature 2000. 408: 740745.
  • 33
    Krieg, A. M., CpG motifs: the active ingredient in bacterial extracts? Nat. Med. 2003. 9: 831835.
  • 34
    Bauer, S., Kirschning, C. J., Hacker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H. and Lipford, G. B., Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 2001. 98: 92379242.
  • 35
    Takeda, K., Kaisho, T. and Akira, S., Toll-like receptors. Annu. Rev. Immunol. 2003. 21: 335376.
  • 36
    Krug, A., Luker, G. D., Barchet, W., Leib, D. A., Akira, S. and Colonna, M., Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 2004. 103: 14331437.
  • 37
    Hochrein, H., Schlatter, B., O'Keeffe, M., Wagner, C., Schmitz, F., Schiemann, M., Bauer, S. et al., Herpes simplex virus type-1 induces IFN-{alpha} production via Toll-like receptor 9-dependent and -independent pathways. Proc. Natl. Acad. Sci. USA 2004. 101: 1141611421.
  • 38
    Lund, J., Sato, A., Akira, S., Medzhitov, R. and Iwasaki, A., Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 2003. 198: 513520.
  • 39
    Rothenfusser, S., Tuma, E., Endres, S. and Hartmann, G., Plasmacytoid dendritic cells: the key to CpG(1). Hum. Immunol. 2002. 63: 11111119.
  • 40
    Gursel, M., Verthelyi, D. and Klinman, D. M., CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells. Eur. J. Immunol. 2002. 32: 26172622.
  • 41
    Krug, A., Rothenfusser, S., Selinger, S., Bock, C., Kerkmann, M., Battiany, J., Sarris, A. et al., CpG-A oligonucleotides induce a monocyte-derived dendritic cell-like phenotype that preferentially activates CD8 T cells. J. Immunol. 2003. 170: 34683477.
  • 42
    Rothenfusser, S., Hornung, V., Krug, A., Towarowski, A., Krieg, A. M., Endres, S. and Hartmann, G., Distinct CpG oligonucleotide sequences activate human gamma delta T cells via interferon-alpha/-beta. Eur. J. Immunol. 2001. 31: 35253534.
  • 43
    Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S. and Hartmann, G., Quantitative expression of toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002. 168: 45314537.
  • 44
    Rothenfusser, S., Hornung, V., Ayyoub, M., Britsch, S., Towarowski, A., Krug, A., Sarris, A. et al., CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro. Blood 2004. 103: 21622169.
  • 45
    Hartmann, G., Weeratna, R. D., Ballas, Z. K., Payette, P., Blackwell, S., Suparto, I., Rasmussen, W. L. et al., Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo. J. Immunol. 2000. 164: 16171624.
  • 46
    Davis, H. L., Suparto, I., Weeratna, R., Jumintarto, Iskandriati, D., Chamzah, S., Ma'ruf, A. et al., CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans. Vaccine 2000. 18: 19201924.
  • 47
    Verthelyi, D., Wang, V. W., Lifson, J. D. and Klinman, D. M., CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques. AIDS 2004. 18: 10031008.
  • 48
    Verthelyi, D., Kenney, R. T., Seder, R. A., Gam, A. A., Friedag, B. and Klinman, D. M., CpG oligodeoxynucleotides as vaccine adjuvants in primates. J. Immunol. 2002. 168: 16591663.
  • 49
    Klinman, D. M., Currie, D., Gursel, I. and Verthelyi, D., Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol. Rev 2004. 199: 201216.
  • 50
    Halperin, S. A., Van Nest, G., Smith, B., Abtahi, S., Whiley, H. and Eiden, J. J., A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 2003. 21: 24612467.
  • 51
    Sprent, J., Zhang, X., Sun, S. and Tough, D., T-cell proliferation in vivo and the role of cytokines. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2000. 355: 317322.
  • 52
    Krug, A., Rothenfusser, S., Hornung, V., Jahrsdorfer, B., Blackwell, S., Ballas, Z. K., Endres, S. et al., Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur. J. Immunol. 2001. 31: 21542163.
  • 53
    Hartmann, G. and Krieg, A. M., Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 2000. 164: 944953.
  • 54
    Kadowaki, N., Antonenko, S., Ho, S., Rissoan, M. C., Soumelis, V., Porcelli, S. A., Lanier, L. L. and Liu, Y. J., Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. J. Exp. Med. 2001. 193: 12211226.
  • 55
    Loza, M. J., Metelitsa, L. S. and Perussia, B., NKT and T cells: coordinate regulation of NK-like phenotype and cytokine production. Eur. J. Immunol. 2002. 32: 34533462.
  • 56
    Steinman, R. M., The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 1991. 9: 271296.
  • 57
    Krug, A., Veeraswamy, R., Pekosz, A., Kanagawa, O., Unanue, E. R., Colonna, M. and Cella, M., Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells. J. Exp. Med. 2003. 197: 899906.
  • 58
    Schlecht, G., Garcia, S., Escriou, N., Freitas, A. A., Leclerc, C. and Dadaglio, G., Murine plasmacytoid dendritic cells induce effector/memory CD8+ T cell responses in vivo after viral stimulation. Blood 2004. 104:18081815.
  • 59
    Salio, M., Cella, M., Vermi, W., Facchetti, F., Palmowski, M. J., Smith, C. L., Shepherd, D. et al., Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions. Eur. J. Immunol. 2003. 33: 10521062.
  • 60
    Ito, T., Amakawa, R., Inaba, M., Hori, T., Ota, M., Nakamura, K., Takebayashi, M. et al., Plasmacytoid dendritic cells regulate Th cell responses through OX40 ligand and type I IFNs. J. Immunol. 2004. 172: 42534259.
  • 61
    Bansal-Pakala, P., Halteman, B. S., Cheng, M. H. and Croft, M., Costimulation of CD8 T cell responses by OX40. J. Immunol. 2004. 172: 48214825.
  • 62
    Taniguchi, M., Harada, M., Kojo, S., Nakayama, T. and Wakao, H., The regulatory role of V{alpha} 14 NKT cells in innate and acquired immune repsonse. Annu. Rev. Immunol. 2003. 21: 483513.
  • 63
    Osman, Y., Kawamura, T., Naito, T., Takeda, K., Van Kaer, L., Okumura, K. and Abo, T., Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur. J. Immunol. 2000. 30: 19191928.
  • 64
    Sfondrini, L., Besusso, D., Zoia, M. T., Rodolfo, M., Invernizzi, A. M., Taniguchi, M., Nakayama, T. et al., Absence of the CD1 molecule up-regulates antitumor activity induced by CpG oligodeoxynucleotides in mice. J. Immunol. 2002. 169: 151158.
  • 65
    Poeck, H., Wagner, M., Battiany, J., Rothenfusser, S., Wellisch, D., Hornung, V., Jahrsdorfer, B. et al., Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2004. 103: 30583064.
  • 66
    Wagner, M., Poeck, H., Jahrsdoerfer, B., Rothenfusser, S., Prell, D., Bohle, B., Tuma, E. et al., IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA. J. Immunol. 2004. 172: 954963.