• 1
    Allen, R. L., Bowness, P. and McMichael, A., The role of HLA-B27 in spondyloarthritis, Immunogenetics 1999. 50: 220227.
  • 2
    Brown, M. A., Pile, K. D., Kennedy, L. G., Calin, A., Darke, C., Bell, J., Wordsworth, B. P. and Cornelis, F., HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom, Ann. Rheum. Dis. 1996. 55: 268270.
  • 3
    Goulder, P. J., Phillips, R. E., Colbert, R. A., McAdam, S., Ogg, G., Nowak, M. A., Giangrande, P., Luzzi, G., Morgan, B., Edwards, A. et al., Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS, Nat. Med. 1997. 3: 212217.
  • 4
    Huet, S., Nixon, D. F., Rothbard, J., Townsend, A. R. M., Ellis, S. A. and McMichael, A. J., Structural homologies between two HLA B27 restricted peptides suggest residues important for interaction with HLA B27. Int. Immunol. 1990. 2: 311316.
  • 5
    Nixon, D. F., Townsend, A. R. M., Elvin, J. G., Rizza, C. R., Gallwey, J. and McMichael, A. J., HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature 1988. 336: 484487.
  • 6
    Wilson, J. D., Ogg, G. S., Allen, R. L., Davis, C., Shaunak, S., Downie, J., Dyer, W., Workman, C., Sullivan, S., McMichael, A. J. and Rowland-Jones, S. L., Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection, AIDS 2000. 14: 225233.
  • 7
    Bowness, P., Moss, P. A. H., Rowland-Jones, S. L., Bell, J. I. and McMichael, A. J., Conservation of T-cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T-lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class-I-restricted responses. Eur. J. Immunol. 1993. 23: 14171421.
  • 8
    Brooks, J. M., Murray, R. J., Thomas, W. A., Kurilla, M. G. and Rickinson, A. B., Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide. J. Exp. Med. 1993. 178: 879887.
  • 9
    Crotzer, V. L., Christian, R. E., Brooks, J. M., Shabanowitz, J., Settlage, R. E., Marto, J. A., White, F. M., Rickinson, A. B., Hunt, D. F. and Engelhard, V. H., Immunodominance among EBV-derived epitopes restricted by HLA-B27 does not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell lines. J. Immunol. 2000. 164: 61206129.
  • 10
    Madden, D. R., Gorga, J. C., Strominger, J. L. and Wiley, D. C., The structure of HLA B27 reveals nonamer self-peptides bound in an extended conformation. Nature 1991. 353: 321325.
  • 11
    Madden, D. R., Gorga, J. C., Strominger, J. L. and Wiley, D. C., The three dimensional structure of HLA-B27 at 2.1Å resolution suggests a general mechanism for tight peptide binding to MHC. Cell 1992. 70: 10351048.
  • 12
    Jardetzky, T. S., Lane, W. S., Robinson, R. A., Madden, D. R. and Wiley, D. C., Identification of self peptides bound to purified HLA-B27. Nature 1991. 353: 326329.
  • 13
    Callan, M. F. C., Reyburn, H. T., Bowness, P., Rowland-Jones, J. S., Bell, J. I. and McMichael, A. J., Selection of T cell receptor variable gene-encoded amino acids on the third binding site loop: a factor influencing variable chain selection in a T cell response. Eur. J. Immunol. 1995. 25: 15291534.
  • 14
    Bowness, P., Allen, R. L., Barclay, D. N., Jones, E. Y. and McMichael, A. J., Importance of a conserved TCR Jα-encoded tyrosine for T cell recognition of an HLA B27/peptide complex. Eur. J. Immunol. 1998. 28: 27042713.
  • 15
    Bowness, P., Allen, R. L. and McMichael, A. J., Identification of T cell receptor recognition residues for a viral peptide presented by HLA B27. Eur. J. Immunol. 1994. 24: 23572363.
  • 16
    Andre, P., Biassoni, R., Colonna, M., Cosman, D., Lanier, L. L., Long, E. O., Lopez-Botet, M., Moretta, A., Moretta, L., Parham, P. et al., New nomenclature for MHC receptors. Nat. Immunol. 2001. 2: 661662.
  • 17
    Cella, M., Longo, A., Ferrara, G. B., Strominger, J. L. and Colonna, M., NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80. J. Exp. Med. 1994. 180: 12351242.
  • 18
    Malnati, M. S., Peruzzi, M., Parker, K. C., Biddison, W. E., Ciccone, E., Moretta, A. and Long, E. O., Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science 1995. 267: 10161018.
  • 19
    Peruzzi, M., Wagtmann, N. and Long, E. O., A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705. J. Exp. Med. 1996. 184: 15851590.
  • 20
    Peruzzi, M., Parker, K. C., Long, E. O. and Malnati, M. S., Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. J. Immunol. 1996. 157: 33503356.
  • 21
    Hulsmeyer, M., Fiorillo, M. T., Bettosini, F., Sorrentino, R., Saenger, W., Ziegler, A. and Uchanska-Ziegler, B. Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J. Exp. Med. 2004. 199: 271281.
  • 22
    Hillig, R. C., Huelsmeyer, M., Saenger, W., Welfle, K., Misselwitz, R., Welfle, H., Kozerski, C., Volz, A., Uchanska-Ziegler, B. and Ziegler, A., Thermodynamic and structural analysis of peptide-and allele-dependent properties of two HLA-B27 subtypes exhibiting differential disease association. J. Biol. Chem. 2003. 10: 16521653.
  • 23
    Madden, D. R., Garboczi, D. N. and Wiley, D. C., The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 1993. 75: 693708.
  • 24
    Speir, J. A., Stevens, J., Joly, E., Butcher, G. W. and Wilson, I. A., Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa. Immunity 2001. 14: 8192.
  • 25
    Colonna, M., Samaridis, J., Cella, M., Angman, L., Allen, R. L., O'Callaghan, C. A., Dunbar, R., Ogg, G. S., Cerundolo, V. and Rolink, A., Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J. Immunol. 1998. 160: 30963100.
  • 26
    Maenaka, K., Maenaka, T., Tomiyama, H., Takiguchi, M., Stuart, D. I. and Jones, E. Y., Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes. J. Immunol. 2000. 165: 32603267.
  • 27
    Fan, Q. R., Long, E. O. and Wiley, D. C., Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat. Immunol. 2001. 2: 452460.
  • 28
    Lopez de Castro, J. A., Alvarez, I., Marcilla, M., Paradela, A., Ramos, M., Sesma, L. and Vazquez, M., HLA-B27: a registry of constitutive peptide ligands. Tissue Antigens 2004. 63: 424445.
  • 29
    Hulsmeyer, M., Hillig, R. C., Volz, A., Ruhl, M., Schroder, W., Saenger, W., Ziegler, A. and Uchanska-Ziegler, B., HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J. Biol. Chem. 2002. 18: 4784447853.
  • 30
    Phillips, R. E., Rowland-Jones, S., Nixon, D. F., Gotch, F. M., Edwards, J. P., Ogunlesi, A. O., Elvin, J. G., Rothbard, J. A., Bangham, C. R. M., Rizza, C. R. and McMichael, A. J., Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 1991. 354: 453459.
  • 31
    Kelleher, A. D., Long, C., Holmes, E. C., Allen, R. L., Wilson, J., Conlon, C., Workman, C., Shaunak, S., Olson, K., Goulder, P. et al., Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med. 2001. 193: 375386.
  • 32
    Goulder, P. J., Brander, C., Tang, Y., Tremblay, C., Colbert, R. A., Addo, M. M., Rosenberg, E. S., Nguyen, T., Allen, R., Trocha, A. et al., Evolution and transmission of stable CTL escape mutations in HIV infection. Nature 2001. 412: 334338.
  • 33
    Garcia, F., Marina, A. and Lopez de Castro, J. A., Lack of carboxyl-terminal tyrosine distinguishes the B*2706-bound peptide repertoire from those of B*2704 and other HLA-B27 subtypes associated with ankylosing spondylitis. Tissue Antigens 1997. 49: 215221.
  • 34
    Kollnberger, S., Bird, L., Sun, M. Y., Retiere, C., Braud, V. M., McMichael, A. and Bowness, P., Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. Arthritis Rheum. 2002. 46: 29722982.
  • 35
    Otwinowski, Z. and Minor, W., Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 1997. 276: 307326.
  • 36
    Kissinger, C. R., Gehlhaar, D. K. and Fogel, D. B., Rapid automated molecular replacement by evolutionary search. Acta Crystallogr. D Biol. Crystallogr. 1999. 55: 484491.
  • 37
    Brunger, A. T., Adams, P. D. and Rice, L. M., Recent developments for the efficient crystallographic refinement of macromolecular structures. Curr. Opin. Struct. Biol. 1998. 8: 606611.
  • 38
    Jones, T. A., Zhou, J. Y., Cdowan, S. W. and Kjeldgaard, M., Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Cryst. 1991. A 47: 110119.
  • 39
    Stuart, D. L., Levine, M., Muirhead, H. and Stammers, D. K., The crystal structure of cat pyruvate kinase at a resolution of 2.6A. J. Mol. Biol. 1979. 134: 109142.
  • 40
    Esnouf, R. M., Further additions to MolScript version 1.4, including reading and contouring of electron-density maps. Acta Crystallogr. 1999. 55: 938940.
  • 41
    Nicholls, A., Sharp, K. A. and Honig, B., Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 1991. 11: 281296.
  • 42
    Allen, R. L., O'Callaghan, C. A., McMichael, A. J. and Bowness, P., Cutting edge: HLA-B27 can form a novel β2-microglobulin-free heavy chain homodimer structure. J. Immunol. 1999. 162: 50455048.