• 1
    Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L. and Wiley, D. C., Structure of the human class I histocompatibility antigen, HLA-A2. Nature 1987. 329: 506512.
  • 2
    Brewerton, D. A., Hart, F. D., Nicholls, A., Caffrey, M., James, D. C. and Sturrock, R. D., Ankylosing spondylitis and HL-A 27. Lancet 1973. 1: 904907.
  • 3
    Brewerton, D. A., Caffrey, M., Nicholls, A., Walters, D., Oates, J. K. and James, D. C., Reiter's disease and HL-A 27. Lancet 1973. 2: 996998.
  • 4
    Benjamin, R. and Parham, P., Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol. Today 1990. 11: 137142.
  • 5
    Mear, J. P., Schreiber, K. L., Münz, C., Zhu, X., Stevanovic, S., Rammensee, H. G., Rowland-Jones, S. L. and Colbert, R. A., Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J. Immunol. 1999. 163: 66656670.
  • 6
    Allen, R. L., Raine, T., Haude, A., Trowsdale, J. and Wilson, M. J., Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures. J. Immunol. 2001. 167: 55435547.
  • 7
    Kollnberger, S., Bird, L., Sun, M. Y., Retiere, C., Braud, V. M., McMichael, A. and Bowness, P., Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. Arthritis Rheum. 2002. 46: 29722982.
  • 8
    Madden, D. R., Gorga, J. C., Strominger, J. L. and Wiley, D. C., The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature 1991. 353: 321325.
  • 9
    Stewart-Jones, G. B. E., di Gleria, K., Kollnberger, S., McMichael, A. J., Jones, E. Y., and Bowness, P., Crystal structures and KIR3DL1 recognition of three immunodominant viral peptides complexed to HLA-B*2705. Eur. J. Immunol. 2005. 35: this issue.
  • 10
    Madden, D. R., Garboczi, D. N. and Wiley, D. C., The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2 [published erratum appears in Cell 1994 Jan 28. 76(2): following 410]. Cell 1993. 75: 693708.
  • 11
    Gomard, E., Sitbon, M., Toubert, A., Begue, B. and Levy, J. P., HLA-B27, a dominant restricting element in antiviral responses? Immunogenetics 1984. 20: 197204.
  • 12
    Goulder, P. J., Phillips, R. E., Colbert, R. A., McAdam, S., Ogg, G., Nowak, M. A., Giangrande, P., Luzzi, G., Morgan, B., Edwards, A. et al., Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 1997. 3: 212217.
  • 13
    Kelleher, A. D., Long, C., Holmes, E. C., Allen, R. L., Wilson, J., Conlon, C., Workman, C., Shaunak, S., Olson, K., Goulder, P. et al., Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses. J. Exp. Med. 2001. 193: 375386.
  • 14
    Lopez de Castro, J. A., Alvarez, I., Marcilla, M., Paradela, A., Ramos, M., Sesma, L., and Vazquez, M., HLA-B27: a registry of constitutive peptide ligands. Tissue Antigens 2004. 63: 424445.
  • 15
    Jardetzky, T. S., Lane, W. S., Robinson, R. A., Madden, D. R. and Wiley, D. C., Identification of self peptides bound to purified HLA-B27. Nature 1991. 353: 326329.
  • 16
    Hillig, R. C., Huelsmeyer, M., Saenger, W., Welfle, K., Misselwitz, R., Welfle, H., Kozerski, C., Volz, A., Uchanska-Ziegler, B. and Ziegler, A., Thermodynamic and structural analysis of peptide-and allele-dependent properties of two HLA-B27 subtypes exhibiting differential disease association. J. Biol. Chem. 2004. 279: 652663.
  • 17
    Ramos, M. and Lopez de Castro, J. A., HLA-B27 and the pathogenesis of spondyloarthritis. Tissue Antigens 2002. 60: 191205.
  • 18
    Hülsmeyer, M., Fiorillo, M. T., Bettosini, F., Sorrentino, R., Saenger, W., Ziegler, A. and Uchanska-Ziegler, B., Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J. Exp. Med. 2004. 199: 271281.
  • 19
    Ramos, M., Paradela, A., Vazquez, M., Marina, A., Vazquez, J. and Lopez de Castro, J. A., Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability. J. Biol. Chem. 2002. 277: 2874928756.
  • 20
    Sesma, L., Montserrat, V., Lamas, J. R., Marina, A., Vazquez, J. and Lopez de Castro, J. A., The peptide repertoires of HLA-B27 subtypes differentially associated to spondyloarthropathy (B*2704 and B*2706) differ by specific changes at three anchor positions. J. Biol. Chem. 2002. 277: 1674416749.
  • 21
    Bowness, P., Allen, R. L., Barclay, D. N., Jones, E. Y. and McMichael, A. J., Importance of a conserved TCR Jα-encoded tyrosine for T cell recognition of an HLA B27/peptide complex. Eur. J. Immunol. 1998. 28: 27042713.
  • 22
    Bowness, P., Moss, P. A., Rowland-Jones, S., Bell, J. I. and McMichael, A. J., Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses. Eur. J. Immunol. 1993. 23: 14171421.
  • 23
    Fiorillo, M. T., Ruckert, C., Hulsmeyer, M., Sorrentino, R., Saenger, W., Ziegler, A. and Uchanska-Ziegler, B., Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes. J. Biol. Chem. 2004. In press: published online as Manuscript M410807200.
  • 24
    Malnati, M. S., Peruzzi, M., Parker, K. C., Biddison, W. E., Ciccone, E., Moretta, A. and Long, E. O., Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science 1995. 267: 10161018.
  • 25
    Peruzzi, M., Wagtmann, N. and Long, E. O., A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B*2705. J. Exp. Med. 1996. 184: 15851590.
  • 26
    Peruzzi, M., Parker, K. C., Long, E. O. and Malnati, M. S., Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. J. Immunol. 1996. 157: 33503356.
  • 27
    Boyington, J. C., Motyka, S. A., Schuck, P., Brooks, A. G. and Sun, P. D., Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature 2000. 405: 537543.
  • 28
    Fan, Q. R., Long, E. O. and Wiley, D. C., Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat. Immunol. 2001. 2: 452460.
  • 29
    Hülsmeyer, M., Hilling, R. C., Volz, A., Rühl, M., Schröder, W., Saenger, W., Ziegler, A. and Uchanska-Ziegler, B., HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J. Biol. Chem. 2002. 277: 4784447853.
  • 30
    Khan, M. A., Update on spondyloarthropathies. Ann. Intern. Med. 2002. 136: 896907.