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  • 1
    Steinman, L., Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996. 85: 299302.
  • 2
    Noseworthy, J. H., Progress in determining the cause and treatment of multiple sclerosis. Nature 1999. 399: A40.
  • 3
    Walker, L. S. and Abbas, A. K., The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2002. 2: 1119.
  • 4
    Stockinger, B., T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. Adv. Immunol. 1999. 71: 229265.
  • 5
    Shevach, E. M., CD4+CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2002. 2: 389400.
  • 6
    Baecher-Allan, C., Brown, J. A., Freeman, G. J. and Hafler, D. A., CD4+CD25high regulatory cells in human peripheral blood. J. Immunol. 2001. 167: 12451253.
  • 7
    Wing, K., Ekmark, A., Karlsson, H., Rudin, A. and Suri-Payer, E., Characterization of human CD25+CD4+ T cells in thymus, cord and adult blood. Immunology 2002. 106: 190199.
  • 8
    Dieckmann, D., Plottner, H., Berchtold, S., Berger, T. and Schuler, G., Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J. Exp. Med. 2001. 193: 13031310.
  • 9
    Jonuleit, H., Schmitt, E., Stassen, M., Tuettenberg, A., Knop, J. and Enk, A. H., Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 2001. 193: 12851294.
  • 10
    Levings, M. K., Sangregorio, R. and Roncarolo, M. G., Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J. Exp. Med. 2001. 193: 12951302.
  • 11
    Stephens, L. A., Mottet, C., Mason, D. and Powrie F., Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 2001. 31: 12471254.
  • 12
    Taams, L. S., Smith, J., Rustin, M. H., Salmon, M., Poulter, L. W. and Akbar, A. N., Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 2001. 31: 11221131.
  • 13
    Taams, L. S., Vukmanovic-Stejic, M., Smith, J., Dunne, P. J., Fletcher, J. M., Plunkett, F. J., Ebeling, S. B. et al., Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells. Eur. J. Immunol. 2002. 32: 16211630.
  • 14
    Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y., Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat. Immunol. 2003. 4: 330336.
  • 15
    Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 10571061.
  • 16
    Khattri, R., Cox, T., Yasayko, S. A. and Ramsdell, F., An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 2003. 4:337342.
  • 17
    Kukreja, A., Cost, G., Marker, J., Zhang, C., Sun, Z., Lin-Su, K., Ten, S. et al., Multiple immunoregulatory defects in type-1 diabetes. J. Clin. Invest. 2002. 109:131140.
  • 18
    Putman, A. L., Vendrame, F. and Gottlieb, P. A., Characterization of CD4+CD25hi T cells in human type 1 diabetes. Clin. Immunol. 2003S1: 177a.
  • 19
    de Kleer, I. M., Wedderburn, L. R., Taams, L. S., Patel, A., Varsani, H., Klein, M., de Jager, W. et al., CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J. Immunol. 2004. 172: 64356443.
  • 20
    Crispin, J. C., Martinez, A. and Alcocer-Varela, J., Quantification of regulatory T cells in patients with systemic lupus erythematosus. J. Autoimmun. 2003. 21: 273276.
  • 21
    Boyer, O., Saadoun, D., Abriol, J., Dodille, M., Piette, J. C., Cacoub, P. and Klatzmann, D., CD4+CD25+ regulatory T cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood 2004. 103: 34283430.
  • 22
    Kriegel, M. A., Lohmann, T., Gabler, C., Blank, N., Kalden, J. R. and Lorenz, H. M., Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J. Exp. Med. 2004. 199: 12851291.
  • 23
    Sugiyama, H., Gyulai, R., Toichi, E., Garaczi, E., Shimada, S., Stevens, S. R., McCormick, T. S. and Cooper, K. D., Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J. Immunol. 2005. 174: 164173.
  • 24
    Viglietta, V., Baecher-Allan, C. M., Weiner, H. L. and Hafler, D. A., Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 2003. 199: 971979.
  • 25
    Mendel, I., Kerlero de Rosbo, N. and Ben-Nun, A., A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur. J. Immunol. 1995. 25: 19511959.
  • 26
    Kohm, A. P., Carpentier, P. A., Anger, H. A. and Miller, S. M., Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 2002. 169: 47124716.
  • 27
    Wing, K., Lindgren, S., Kollberg, G., Lundgren, A., Harris, R. A., Rudin, A., Lundin, S. and Suri-Payer, E., CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells. Eur. J. Immunol. 2003. 33: 579587.
  • 28
    Reem, G. H., Yeh, N. H., Urdal, D. L., Kilian, P. L. and Farrar, J. J., Induction and upregulation by interleukin 2 of high-affinity interleukin 2 receptors on thymocytes and T cells. Proc. Natl. Acad. Sci. USA 1985. 82: 86638666.
  • 29
    Hazenberg, M. D., Verschuren, M. C., Hamann, D., Miedema, F. and van Dongen, J. J., T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J. Mol. Med. 2001. 79: 631640.
  • 30
    Hug, A., Korporal, M., Schröder, I., Haas, J., Glatz, K., Storch-Hagenlocher, B. and Wildemann, B., Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis. J. Immunol. 2003. 171: 432437.
  • 31
    Lindert, R. B., Haase, C. G., Brehm, U., Linington, C., Wekerle, H. and Hohlfeld, R., Multiple sclerosis: B and T cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain 1999. 122: 20892100.
  • 32
    Diaz-Villoslada, P., Shih, A., Shao, L., Genain, C. P. and Hauser, S. L., Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen. J. Neuroimmunol. 1999. 99: 3643.
  • 33
    Traggiai, E., Biagioli, T., Rosati, E., Ballerini, C., Mazzanti, B., Ben Nun, A., Massacesi, L. and Vergelli, M., IL-7-enhanced T cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol. 2001. 121: 111119.
  • 34
    Hellings, N., Baree, M., Verhoeven, C., D'hooghe, M. B., Medaer, R., Bernard, C. C., Raus, J. and Stinissen, P., T cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls. J. Neurosci. Res. 2001. 63: 290302.
  • 35
    Thornton, A. M. and Shevach, E. M., CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287296.
  • 36
    Bensinger, S. J., Walsh, P. T., Zhang, J., Carroll, M., Parsons, R., Rathmell, J. C., Thompson, C. B. et al., Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J. Immunol. 2004. 172: 52875296.
  • 37
    Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E. et al., The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of Foxp3. Nat. Genet. 2001. 27: 2021.
  • 38
    Kurtzke, J. F., Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983. 33: 14441452.
  • 39
    Ehrenstein, M. R., Evans, J. G., Singh, A., Moore, S., Warnes, G., Isenberg, D. A. and Mauri, C., Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy. J. Exp. Med. 2004. 200: 277285.
  • 40
    Cao, D., Malmstrom, V., Baecher-Allan, C., Hafler, D., Klareskog, L. and Trollmo, C., Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. Eur. J. Immunol. 2003. 33: 215223.
  • 41
    Poser, C. M. and Paty, D. W., Scheinberg L., New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 1983. 13: 227231.
  • 42
    Fritzsching, B. F., Schwer, B., Kartenbeck, J., Pedal, A., Horejsi, V. and Ott, M., Release and intercellular transfer of cell surface CD81 via microparticles. J. Immunol. 2002. 169: 55315537.