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  • 1
    Trapani, J. A. and Smyth, M. J., Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2002. 2: 735747.
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    Barry, M., Bleackley, R. C., Cytotoxic lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2002. 2: 401409.
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    Lieberman, J., The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat. Rev. Immunol. 2003. 3: 361370.
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    Trapani, J. A., Sutton, V. R., Thia, K. Y., Li, Y. Q., Froelich, C. J., Jans, D. A., Sandrin, M. S. and Browne, K. A., A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J. Cell Biol. 2003. 160: 223233.
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    Veugelers, K., Motyka, B., Frantz, C., Shostak, I., Sawchuk, T. and Bleackley, R. C., The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. Blood 2004. 103: 38453853.
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    Froelich, C. J., Orth, K., Turbov, J., Seth, P., Gottlieb, R., Babior, B., Shah, G. M. et al., New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J. Biol. Chem. 1996. 271: 2907329079.
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    Browne, K. A., Blink, E., Sutton, V. R., Froelich, C. J., Jans, D. A. and Trapani, J. A., Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin . Mol. Cell. Biol. 1999. 19: 86048615.
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    Wilharm, E., Parry, M. A., Friebel, R., Tschesche, H., Matschiner, G., Sommerhoff, C. P. and Jenne, D. E., Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma. J. Biol. Chem. 1999. 274: 2733127337.
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    Waugh, S. M., Harris, J. L., Fletterick, R. and Craik, C. S., The structure of the pro-apoptotic protease granyzme B reveals the molecular determinants of its specificity. Nat. Struct. Biol. 2000. 7: 762765.
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    Estebanez-Perpina, E., Fuentes-Prior, P., Belorgey, D., Braun, M., Kiefersauer, R., Maskos, K., Huber, R. et al., Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue. Biol. Chem. 2000. 381: 12031214.
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    Bell, J. K., Goetz, D. H., Mahrus, S., Harris, J. L., Fletterick, R. J. and Craik, C. S. The oligomeric structure of human granyzme A is a determinant of its extended substrate specificity. Nat. Struct. Biol. 2003. 10: 527534.
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    Hink-Schauer, C., Estebanez-Perpina, E., Kurschus, F. C., Bode, W. and Jenne, D. E., Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat. Struct. Biol. 2003. 10: 535540.
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    Hamann, D., Baars, P. A., Rep, M. H., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R. and van Lier, R. A., Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 1997. 186: 14071418.
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    Faint, J. M., Annels, N. E., Curnow, S. J., Shields, P., Pilling, D., Hislop, A. D., Wu, L. et al., Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics. J. Immunol. 2001. 167: 212220.
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    Campbell, J. J., Bowman, E. P., Murphy, K., Youngman, K. R., Siani, M. A., Thompson, D. A., Wu, L., et al., 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3β receptor CCR7. J. Cell. Biol. 1998. 141: 10531059.
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