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    Jordan, M. S., Boesteanu, A., Reed, A. J., Petrone, A. L., Holenbeck, A. E., Lerman, M. A., Naji, A. and Caton, A. J., Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001. 2: 301306.
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    Unger, W. W., Jansen, W., Wolvers, D. A., van Halteren, A. G., Kraal, G. and Samsom, J. N., Nasal tolerance induces antigen-specific CD4+CD25 regulatory T cells that can transfer their regulatory capacity to naive CD4+ T cells. Int. Immunol. 2003. 15: 731739.
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    Fu, S., Zhang, N., Yopp, A. C., Chen, D., Mao, M., Chen, D., Zhang, H. et al., TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 precursors. Am. J. Transplant. 2004. 4: 16141627.
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    Sykes, M., Mixed chimerism and transplant tolerance. Immunity 2001. 14: 417424.
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    Kurtz, J., Wekerle, T. and Sykes, M., Tolerance in mixed chimerism - a role for regulatory cells? Trends Immunol. 2004. 25: 518523.
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    Takeuchi, Y., Ito, H., Kurtz, J., Wekerle, T., Ho, L. and Sykes, M., Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L. Am. J. Transplant. 2004. 4: 3140.
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    Wekerle, T., Sayegh, M. H., Ito, H., Hill, J., Chandraker, A., Pearson, D. A., Swenson, K. G. et al., Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation 1999. 68: 13481355.
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    Malek, T. R. and Bayer, A. L., Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 2004. 4: 665674.
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    Salomon, B. and Bluestone, J. A., Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 2001. 19: 225252.
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    Kurtz, J., Shaffer, J., Anosova, N., Benichou, G. and Sykes, M., Mechanisms of early peripheral CD4 T cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: Evidence for anergy and deletion, but not regulatory cells. Blood 2004. 103: 43364343.
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    Ito, H., Kurtz, J., Shaffer, J. and Sykes, M., CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40L interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway. J. Immunol. 2001. 166: 2981.
  • 27
    Kurtz, J., Ito, H., Wekerle, T., Shaffer, J. and Sykes, M., Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: Lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells. Am. J. Transplant. 2001. 1: 339349.
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    Wekerle, T., Sayegh, M. H., Hill, J., Zhao, Y., Chandraker, A., Swenson, K. G., Zhao, G. and Sykes, M., Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J. Exp. Med. 1998. 187: 20372044.
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    Lakkis, F. G. and Dai, Z., The role of cytokines, CTLA-4 and costimulation in transplant tolerance and rejection. Curr. Opin. Immunol. 1999. 11: 504508.
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    Kishimoto, K., Sandner, S., Imitola, J., Sho, M., Li, Y., Langmuir, P. B., Rothstein, D. M. et al., Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J. Clin. Invest. 2002. 109: 14711479.
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    Dai, Z., Konieczny, B. T., Baddoura, F. K. and Lakkis, F. G., Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice. J. Immunol. 1998. 161: 16591663.
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    Piccirillo, C. A. and Shevach, E. M., Cutting edge: control of CD8(+) T cell activation by CD4(+)CD25(+) immunoregulatory cells. J. Immunol. 2001. 167: 11371140.
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    van Maurik, A., Herber, M., Wood, K. J. and Jones, N. D., Cutting edge: CD4(+)CD25(+) alloantigen-specific immunoregulatory cells that can prevent CD8(+) T cell-mediated graft rejection: implications for anti-CD154 immunotherapy. J. Immunol. 2002. 169: 54015404.
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    Dai, Z., Li, Q., Wang, Y., Gao, G., Diggs, L. S., Tellides, G. and Lakkis, F. G., CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism. J. Clin. Invest. 2004. 113: 310317.
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    Homann, D., Jahreis, A., Wolfe, T., Hughes, A., Coon, B., van Stipdonk, M. J., Prilliman, K. R. et al., CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity 2002. 16: 403415.
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    Yang, Y. -G., Dey, B., Sergio, J. J., Pearson, D. A. and Sykes, M., Donor-derived Interferon γ is required for inhibition of acute GVHD by interleukin 12. J. Clin. Invest. 1998. 102: 21262135.
  • 40
    Welniak, L. A., Blazar, B. R., Anver, M. R., Wiltrout, R. H. and Murphy, W. J., Opposing roles of interferon-gamma on CD4+ T cell-mediated graft-versus- host disease: effects of conditioning. Biol. Blood Marrow Transplant. 2000. 6: 604612.
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    Nishibori, T., Tanabe, Y., Su, L. and David, M., Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J. Exp. Med. 2004. 199: 2534.
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    Seder, R. A. and Ahmed, R., Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat. Immunol. 2003. 4: 835842.
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    Badovinac, V. P., Tvinnereim, A. R. and Harty, J. T., Regulation of antigen-specific CD8(+) T cell homeostasis by perforin and interferon-gamma. Science 2000. 290: 13541358.
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    Rafaeli, Y., Van Parijs, L., Alexander, S. I. and Abbas, A. K., Interferon gamma is required for activation-induced death of T lymphocytes. J. Exp. Med. 2002. 196: 9991005.
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    Kurtz, J., Lie, A., Griffith, M., Eysaman, S., Shaffer, J., Anosova, N., Turka, L. et al., Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4+ T cells via BMT and anti-CD40L. Am. J. Transplant. 2003. 3: 804816.
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    Van Parijs, L., Biuckians, A., Ibragimov, A., Alt, F. W., Willerford, D. M. and Abbas, A. K., Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J. Immunol. 1997. 158: 37383745.
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    Dai, Z., Arakelov, A., Wagener, M., Konieczny, B. T. and Lakkis, F. G., The role of the common cytokine receptor γ-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death. J. Immunol. 1999. 163: 31313137.
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    Demirci, G., Ferrari-Lacraz, S., Groves, C., Coyle, A., Malek, T. R., Strom, T. B. and Li, X. C., IL-15 and IL-2: a matter of life and death for T cells in vivo. Nat. Med. 2001. 7: 114118.
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    Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2000. 192: 303310.
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    Markees, T. G., Phillips, N. E., Noelle, R. J., Shultz, L. D., Mordes, J. P., Greiner, D. L. and Rossini, A. A., Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand. Transplantation 1997. 64: 329335.
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    Iwakoshi, N. N., Mordes, J. P., Markees, T. G., Phillips, N. E., Rossini, A. A. and Greiner, D. L., Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner. J. Immunol. 2000. 164: 512521.
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    Iwakoshi, N. N., Markees, T. G., Turgeon, N., Thornley, T., Cuthbert, A., Leif, J., Phillips, N. E. et al., Skin allograft maintenance in a new synchimeric model system of tolerance. J. Immunol. 2001. 167: 66236630.
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    Khan, A., Tomita, Y. and Sykes, M., Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance. Transplantation 1996. 62: 380387.
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    Sykes, M., Chester, C. H., Sundt, T. M., Romick, M. L., Hoyles, K. A. and Sachs, D. H., Effects of T cell depletion in radiation bone marrow chimeras: III. Characterization of allogeneic bone marrow cell populations that increase allogeneic chimerism independently of graft-vs-host disease in mixed marrow recipients. J. Immunol. 1989. 143: 35033511.
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    Tomita, Y., Sachs, D. H., Khan, A. and Sykes, M., Additional mAb injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3 Gy whole body irradiation. Transplantation 1996. 61: 469477.