• 1
    Ottenhoff, T. H., Verreck, F. A., Lichtenauer-Kaligis, E. G. Hoeve, M. A. Sanal, O. and van Dissel J. T., Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae. Nat. Genet 2002. 32: 97105.
  • 2
    Trinchieri, G., Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol 2003. 3: 133146.
  • 3
    Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F. et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 . Immunity 2002. 13: 715725.
  • 4
    Verreck, F. A., de Boer, T., Langenberg, D. M., Hoeve, M. A., Kramer, M., Vaisberg, M. E., Kastelein, R. et al., Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc. Natl. Acad. Sci. USA 2004. 101: 45604565.
  • 5
    Parham, C., Chirica, M., Timans, J., Vaisberg, E., Travis, M., Cheung, J. and Pflanz, S., A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol 2002. 168: 56995708.
  • 6
    Hoeve, M. A., de Boer, T., Langenberg, D. M. Sanal, O., Verreck, F. A. and Ottenhoff, T. H., IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency. Eur. J. Immunol 2003. 33: 33933397.
  • 7
    Trinchieri, G., Pflanz, S. and Kastelein, R. A., The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2003. 19: 641644.
  • 8
    Wiekowski, M. T., Leach, M. W., Evans, E. W., Sullivan, L., Chen, S. C., Vassileva, G., Bazan, J. F. et al., Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol 2001. 166: 75637570.
  • 9
    Becher, B., Durell, B. G. and Noelle, R. J., Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest 2002. 110: 493497.
  • 10
    Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L. et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003. 421: 744748.
  • 11
    Gran, B., Zhang, G. X., Yu, S., Li, J., Chen, X. H., Ventura, E. S., Kamoun, M. et al., IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol 2002. 169: 71047110.
  • 12
    Murphy, C. A., Langrish, C. L. Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D. et al., Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med 2003. 198: 19511957.
  • 13
    Zhang, G. X., Gran, B., Yu, S., Li, J., Siglienti, I., Chen, X., Kamoun, M. and Rostami, A., Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J. Immunol 2003. 170: 21532160.
  • 14
    Zhang, G. X., Yu, S., Gran, B., Li, J., Siglienti, I., Chen, X., Calida, D. et al., Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis. J. Immunol 2003. 171: 44854492.
  • 15
    Aggarwal, S., Ghilardi, N., Xie, M. H., de Sauvage, F. J. and Gurney, A. L., Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem 2003. 278: 19101914.
  • 16
    Yao, Z., Painter, S. L. Fanslow, W. C., Ulrich, D., Macduff, B. M., Spriggs, M. K. and Armitage, R. J., Human IL-17: a novel cytokine derived from T cells. J. Immunol. 1995. 155: 54835486.
  • 17
    Aggarwal, S. and Gurney, A. L., IL-17: prototype member of an emerging cytokine family. J. Leukoc. Biol. 2002. 71: 18.
  • 18
    Miossec, P., Interleukin-17 in rheumatoid arthritis: if T cells were to contribute to inflammation and destruction through synergy. Arthritis Rheum 2003. 48: 594601.
  • 19
    Fossiez, F., Djossou, O., Chomarat, P., FloresRomo, L., AitYahia, S., Maat, C., Pin, J. J. et al., T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med 1996. 183: 25932603.
  • 20
    Shin, H. C., Benbernou, N., Esnault, S. and Guenounou, M., Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine 1999. 11: 257266.
  • 21
    Aarvak, T., Chabaud, M., Miossec, P. and Natvig, J. B., IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J. Immunol 1999. 162: 12461251.
  • 22
    Albanesi, C., Cavani, A. and Girolomoni, G., IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: Synergistic or antagonist effects with IFN-gamma and TNF-alpha. J. Immunol. 1999. 162: 494502.
  • 23
    Albanesi, C., Scarponi, C. S., Cavani, A., Federici, M., Nasorri, F. and Girolomoni, G., Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes. J. Invest. Dermatol 2000. 115: 8187.
  • 24
    Ziolkowska, M., Koc, A., Luszczykiewicz, G., Ksiezopolska-Pietrzak, K., Klimczak, E., Chwalinska-Sadowska, H. and Maslinski, W., High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J. Immunol 2000. 164: 28322838.
  • 25
    Ferretti, S., Bonneau, O., Dubois, G. R., Jones, C. E. and Trifilieff, A., IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol 2003. 170: 21062112.
  • 26
    Cleary, A. M., Tu, W. W., Enright, A., Giffon, T., De-waal-Malefyt, R., Gutierrez, K. and Lewis, D. B., Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. J. Immunol 2003. 170: 597603.
  • 27
    Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S. et al., IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J. Clin. Invest 1999. 103:13451352.
  • 28
    Nakae, S., Nambu, A., Sudo, K. and Iwakura, Y., Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol 2003. 171: 61736177.
  • 29
    Kurasawa, K., Hirose, K., Sano, H., Endo, H., Shinkai, H., Nawata, Y., Takabayashi, K. et al., Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum 2000. 43: 24552463.
  • 30
    Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E., Garren, H., Langer-Gould, A. et al., Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002. 8: 500508.
  • 31
    Harrington, L. E, Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., Weaver, C. T., Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005. 6: 11231132.
  • 32
    Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y. H., Wang, Y. et al., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005. 6: 11331141.
  • 33
    Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T. et al., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005. 201: 233240.
  • 34
    McKenzie, B. S., Kastelein, R. A., Daniel, J. and Cua, D. J., Understanding the IL-23–IL-17 immune pathway. Trends Immunol. 2005, in press.
  • 35
    Wynn, T. A., T(H)-17: a giant step from T(H)1 and T(H)2. Nat. Immunol. 2005. 6: 10691070.
  • 36
    Smits, H. H., van Beelen, A. J., Hessle, C., Westland, R., de Jong, E., Soeteman, E., Wold, A. et al., Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur. J. Immunol 2004. 34: 137180.
  • 37
    Schnurr, M., Toy, T., Shin, A., Wagner, M., Cebon, J. and Maraskovsky, E., Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway. Blood 2005. 105: 15821589.
  • 38
    Trinchieri, G., Biological properties and therapeutic applications of interleukin-12. Eur. Cytokine Netw 1997. 8: 305307.