• 1
    Kuppers, R., Klein, U., Hansmann, M. L. and Rajewsky, K., Cellular origin of human B-cell lymphomas. N. Engl. J. Med. 1999. 341: 15201529.
  • 2
    Weill, J. C., Weller, S. and Reynaud, C. A., A bird's eye view on human B cells. Semin. Immunol. 2004. 16: 277281.
  • 3
    Klein, U., Rajewsky, K. and Kuppers, R., Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 1998. 188: 16791689.
  • 4
    Agematsu, K., Hokibara, S., Nagumo, H. and Komiyama, A., CD27: A memory B-cell marker. Immunol. Today 2000. 21: 204206.
  • 5
    Klein, U., Kuppers, R. and Rajewsky, K., Evidence for a large compartment of IgM-expressing memory B cells in humans. Blood 1997. 89: 12881298.
  • 6
    Weller, S., Braun, M. C., Tan, B. K., Rosenwald, A., Cordier, C., Conley, M. E., Plebani, A. et al., Human blood IgM “memory” B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 2004. 104: 36473654.
  • 7
    Kruetzmann, S., Rosado, M. M., Weber, H., Germing, U., Tournilhac, O., Peter, H. H., Berner, R. et al., Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J. Exp. Med. 2003. 197: 939945.
  • 8
    Odendahl, M., Jacobi, A., Hansen, A., Feist, E., Hiepe, F., Burmester, G. R., Lipsky, P. E. et al., Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J. Immunol. 2000. 165: 59705979.
  • 9
    Avery, D. T., Ellyard, J. I., Mackay, F., Corcoran, L. M., Hodgkin, P. D. and Tangye, S. G., Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. J. Immunol. 2005. 174: 40344042.
  • 10
    Carsetti, R., Rosado, M. M. and Wardmann, H., Peripheral development of B cells in mouse and man. Immunol. Rev. 2004. 197: 179191.
  • 11
    Sims, G. P., Ettinger, R., Shirota, Y., Yarboro, C. H., Illei, G. G. and Lipsky, P. E., Identification and characterization of circulating human transitional B cells. Blood 2005. 105: 43904398.
  • 12
    Gaudin, E., Rosado, M., Agenes, F., McLean, A. and Freitas, A. A., B-cell homeostasis, competition, resources, and positive selection by self-antigens. Immunol. Rev. 2004. 197: 102115.
  • 13
    Nunez, C., Nishimoto, N., Gartland, G. L., Billips, L. G., Burrows, P. D., Kubagawa, H. and Cooper, M. D., B cells are generated throughout life in humans. J. Immunol. 1996. 156: 866872.
  • 14
    Glynne, R., Ghandour, G., Rayner, J., Mack, D. H. and Goodnow, C. C., B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunol. Rev. 2000. 176: 216246.
  • 15
    Forster, I. and Rajewsky, K., The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow. Proc. Natl. Acad. Sci. USA 1990. 87: 47814784.
  • 16
    Allman, D. M., Ferguson, S. E., Lentz, V. M. and Cancro, M. P., Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 1993. 151: 44314444.
  • 17
    Bernasconi, N. L., Traggiai, E. and Lanzavecchia, A., Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002. 298: 21992202.
  • 18
    Macallan, D. C., Wallace, D. L., Zhang, Y., Ghattas, H., Asquith, B., de Lara, C., Worth, A. et al., B cell kinetics in humans: Rapid turnover of peripheral blood memory cells. Blood 2005. 105: 36333640.
  • 19
    Dean, M., (Ed.) The human ATP-binding cassette (ABC) transporter superfamily. National Library of Medicine, NCBI 2002.
  • 20
    Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A. and Lemischka, I. R., A stem cell molecular signature. Science 2002. 298: 601604.
  • 21
    Chaudhary, P. M. and Roninson, I. B., Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 1991. 66: 8594.
  • 22
    Chaudhary, P. M., Mechetner, E. B. and Roninson, I. B., Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 1992. 80: 27352739.
  • 23
    Klimecki, W. T., Futscher, B. W., Grogan, T. M. and Dalton, W. S., P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood 1994. 83: 24512458.
  • 24
    Honig, S. M., Fu, S., Mao, X., Yopp, A., Gunn, M. D., Randolph, G. J. and Bromberg, J. S., FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. J. Clin. Invest. 2003. 111: 627637.
  • 25
    Ghetie, M. A., Marches, R., Kufert, S. and Vitetta, E. S., An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-gp) and CD19, causes P-gp to translocate out of lipid rafts, and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line. Blood 2004. 104: 178183.
  • 26
    Traggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M. R., Murphy, B. R. et al., An efficient method to make human monoclonal antibodies from memory B cells: Potent neutralization of SARS coronavirus. Nat. Med. 2004. 10: 871875.
  • 27
    Pitcher, C. J., Hagen, S. I., Walker, J. M., Lum, R., Mitchell, B. L., Maino, V. C., Axthelm, M. K. et al., Development and homeostasis of T cell memory in rhesus macaque. J. Immunol. 2002. 168: 2943.
  • 28
    Picker, L. J., Hagen, S. I., Lum, R., Reed-Inderbitzin, E. F., Daly, L. M., Sylwester, A. W., Walker, J. M. et al., Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J. Exp. Med. 2004. 200: 12991314.
  • 29
    Jaimes, M. C., Rojas, O. L., Kunkel, E. J., Lazarus, N. H., Soler, D., Butcher, E. C., Bass, D. et al., Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in children. J. Virol. 2004. 78: 1096710976.
  • 30
    Tangye, S. G., Ferguson, A., Avery, D. T., Ma, C. S. and Hodgkin, P. D., Isotype switching by human B cells is division-associated and regulated by cytokines. J. Immunol. 2002. 169: 42984306.
  • 31
    O'Connor, B. P., Cascalho, M. and Noelle, R. J., Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population. J. Exp. Med. 2002. 195: 737745.
  • 32
    Garrigues, A., Escargueil, A. E. and Orlowski, S., The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane. Proc. Natl. Acad. Sci. USA 2002. 99: 1034710352.
  • 33
    Pierce, S. K., Lipid rafts and B-cell activation. Nat. Rev. Immunol. 2002. 2: 96105.