• 1
    Gracie, J. A., Robertson, S. E. and McInnes, I. B., Interleukin-18. J. Leukoc. Biol. 2003. 73: 213224.
  • 2
    Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L. et al., Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997. 386: 619623.
  • 3
    Gu, Y., Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N. et al., Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 1997. 275: 206209.
  • 4
    Fantuzzi, G. and Dinarello, C. A., Interleukin-18 and interleukin-1 beta: Two cytokine substrates for ICE (Caspase-1). J. Clin. Immunol. 1999. 19: 111.
  • 5
    Sugawara, S., Uehara, A., Nochi, T., Yamaguchi, T., Ueda, H., Sugiyama, A., Hanzawa, K. et al., Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J. Immunol. 2001. 167: 65686575.
  • 6
    Akita, K., Ohtsuki, T., Nukada, Y., Tanimoto, T., Namba, M., Okura, T., Takakura-Yamamoto, R. et al., Involvement of Caspase-1 and Caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. J. Biol. Chem. 1997. 272: 2659526603.
  • 7
    Nakamura, K., Okamura, H., Wada, M., Nagata, K. and Tamura, T., Endotoxin-induced serum factor that stimulates gamma interferon production. Infect. Immun. 1989. 57: 590595.
  • 8
    Okamura, H., Tsutsi, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K. et al., Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995. 378: 8891.
  • 9
    Micallef, M. J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T. et al., Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production. Eur. J. Immunol. 1996. 26: 16471651.
  • 10
    Dao, T., Mehal, W. Z. and Crispe, I. N., IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells. J. Immunol. 1998. 161: 22172222.
  • 11
    Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kashiwamura, S., Okamura, H., Akira, S. et al., IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production. J. Immunol. 1998. 161: 34003407.
  • 12
    Olee, T., Hashimoto, S., Quach, J. and Lotz, M., IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J. Immunol. 1999. 162: 10961100.
  • 13
    Dao, T., Ohashi, K., Kayano, T., Kurimoto, M. and Okamura, H., Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell. Immunol. 1996. 173: 230235.
  • 14
    Munder, M., Mallo, M., Eichmann, K. and Modolell, M., Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. J. Exp. Med. 1998. 187: 21032108.
  • 15
    Sugawara, I., Yamada, H., Kaneko, H., Mizuno, S., Takeda, K. and Akira, S., Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect. Immun. 1999. 67: 25852589.
  • 16
    Lauw, F. N., Branger, J., Florquin, S., Speelman, P., van Deventer, S. J., Akira, S. and van der Poll, T., IL-18 improves the early antimicrobial host response to pneumococcal pneumonia. J. Immunol. 2002. 168: 372378.
  • 17
    Wei, X. Q., Leung, B. P., Niedbala, W., Piedrafita, D., Feng, G. J., Sweet, M., Dobbie, L. et al., Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. J. Immunol. 1999. 163: 28212828.
  • 18
    Mastroeni, P., Clare, S., Khan, S., Harrison, J. A., Hormaeche, C. E., Okamura, H., Kurimoto, M. et al., Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium. Infect. Immun. 1999. 67: 478483.
  • 19
    Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J. et al., IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J. Immunol. 1998. 160: 299307.
  • 20
    Leung, B. P., Culshaw, S., Gracie, J. A., Hunter, D., Canetti, C. A., Campbell, C., Cunha, F. et al., A role for IL-18 in neutrophil activation. J. Immunol. 2001. 167: 28792886.
  • 21
    Wei, X. Q., Leung, B. P., Arthur, H. M., McInnes, I. B. and Liew, F. Y., Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18. J. Immunol. 2001. 166: 517521.
  • 22
    Cassatella, M. A., Neutrophil-derived proteins: Selling cytokines by the pound. Adv. Immunol. 1999. 73: 369509.
  • 23
    Borregaard, N., Lollike, K., Kjeldsen, L., Sengelov, H., Bastholm, L., Nielsen, M. H. and Bainton, D. F., Human neutrophil granules and secretory vesicles. Eur. J. Haematol. 1993. 51: 187198.
  • 24
    Campbell, E. J., Silverman, E. K. and Campbell, M. A., Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity. J. Immunol. 1989. 143: 29612968.
  • 25
    Owen, C. A., Campbell, M. A., Boukedes, S. S. and Campbell, E. J., Inducible binding of bioactive cathepsin G to the cell surface of neutrophils. A novel mechanism for mediating extracellular catalytic activity of cathepsin G. J. Immunol. 1995. 155: 58035810.
  • 26
    Campbell, E. J., Campbell, M. A. and Owen, C. A., Bioactive proteinase 3 on the cell surface of human neutrophils: Quantification, catalytic activity, and susceptibility to inhibition. J. Immunol. 2000. 165: 33663374.
  • 27
    Capodici, C. and Berg, R. A., Cathepsin g degrades denatured collagen. Inflammation 1989. 13: 137145.
  • 28
    Reilly, C. F., Tewksbury, D. A., Schechter, N. M. and Travis, J., Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. J. Biol. Chem. 1982. 257: 86198622.
  • 29
    Coeshott, C., Ohnemus, C., Pilyavskaya, A., Ross, S., Wieczorek, M., Kroona, H., Leimer, A. H. et al., Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc. Natl. Acad. Sci. USA 1999. 96: 62616266.
  • 30
    Bank, U., Kupper, B. and Ansorge, S., Inactivation of interleukin-6 by neutrophil proteases at sites of inflammation. Protective effects of soluble IL-6 receptor chains. Adv. Exp. Med. Biol. 2000. 477: 431437.
  • 31
    Padrines, M., Wolf, M., Walz, A. and Baggiolini, M., Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3. FEBS Lett. 1994. 352: 231235.
  • 32
    Scuderi, P., Nez, P. A., Duerr, M. L., Wong, B. J. and Valdez, C. M., Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin. Cell. Immunol. 1991. 135: 299313.
  • 33
    van Kessel, K. P., van Strijp, J. A. and Verhoef, J., Inactivation of recombinant human tumor necrosis factor-alpha by proteolytic enzymes released from stimulated human neutrophils. J. Immunol. 1991. 147: 38623868.
  • 34
    Gracie, J. A., Forsey, R. J., Chan, W. L., Gilmour, A., Leung, B. P., Greer, M. R., Kennedy, K. et al., A proinflammatory role for IL-18 in rheumatoid arthritis. J. Clin. Invest. 1999. 104: 13931401.
  • 35
    Leung, B. P., McInnes, I. B., Esfandiari, E., Wei, X. Q. and Liew, F. Y., Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis. J. Immunol. 2000. 164: 64956502.
  • 36
    Ferrari, D., Chiozzi, P., Falzoni, S., Dal Susino, M., Melchiorri, L., Baricordi, O. R. and Di Virgilio, F., Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 1997. 159: 14511458.
  • 37
    Mehta, V. B., Hart, J. and Wewers, M. D., ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J. Biol. Chem. 2001. 276: 38203826.
  • 38
    Canetti, C. A., Leung, B. P., Culshaw, S., McInnes, I. B., Cunha, F. Q. and Liew, F. Y., IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4. J. Immunol. 2003. 171: 10091015.
  • 39
    Jordan, J. A., Guo, R. F., Yun, E. C., Sarma, V., Warner, R. L., Crouch, L. D., Senaldi, G. et al., Role of IL-18 in acute lung inflammation. J. Immunol. 2001. 167: 70607068.
  • 40
    Netea, M. G., Fantuzzi, G., Kullberg, B. J., Stuyt, R. J., Pulido, E. J., McIntyre, R. C., Jr., Joosten, L. A. et al., Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia. J. Immunol. 2000. 164: 26442649.
  • 41
    Hazuda, D. J., Strickler, J., Kueppers, F., Simon, P. L. and Young, P. R., Processing of precursor interleukin 1 beta and inflammatory disease. J. Biol. Chem. 1990. 265: 63186322.
  • 42
    Leavell, K. J., Peterson, M. W. and Gross, T. J., Human neutrophil elastase abolishes interleukin-8 chemotactic activity. J. Leukoc. Biol. 1997. 61: 361366.
  • 43
    Que, X., Kim, S. H., Sajid, M., Eckmann, L., Dinarello, C. A., McKerrow, J. H. and Reed, S. L., A surface amebic cysteine proteinase inactivates interleukin-18. Infect. Immun. 2003. 71: 12741280.
  • 44
    Novick, D., Kim, S. H., Fantuzzi, G., Reznikov, L. L., Dinarello, C. A. and Rubinstein, M., Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response. Immunity 1999. 10: 127136.
  • 45
    Wyman, T. H., Dinarello, C. A., Banerjee, A., Gamboni-Robertson, F., Hiester, A. A., England, K. M., Kelher, M. et al., Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 map kinase activation. J. Leukoc. Biol. 2002. 72: 401409.
  • 46
    Puren, A. J., Fantuzzi, G. and Dinarello, C. A., Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc. Natl. Acad. Sci. USA 1999. 96: 22562261.
  • 47
    Gonias, S. L., Young, W. W., Jr. and Fox, J. W., Cleavage of recombinant murine interferon-gamma by plasmin and miniplasmin. J. Interferon Res. 1989. 9: 517529.
  • 48
    Kim, S. H., Azam, T., Novick, D., Yoon, D. Y., Reznikov, L. L., Bufler, P., Rubinstein, M. et al., Identification of amino acid residues critical for biological activity in human interleukin-18. J. Biol. Chem. 2002. 277: 1099811003.
  • 49
    Kim, S. H., Azam, T., Yoon, D. Y., Reznikov, L. L., Novick, D., Rubinstein, M. and Dinarello, C. A., Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein. Proc. Natl. Acad. Sci. USA 2001. 98: 33043309.
  • 50
    Jablonska, E., Puzewska, W., Grabowska, Z., Jablonski, J. and Talarek, L., VEGF, IL-18 and NO production by neutrophils and their serum levels in patients with oral cavity cancer. Cytokine 2005. 30: 9399.
  • 51
    Perregaux, D. G., McNiff, P., Laliberte, R., Conklyn, M. and Gabel, C. A., ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood. J. Immunol. 2000. 165: 46154623.
  • 52
    Suh, B. C., Kim, J. S., Namgung, U., Ha, H. and Kim, K. T., P2X7 nucleotide receptor mediation of membrane pore formation and superoxide generation in human promyelocytes and neutrophils. J. Immunol. 2001. 166: 67546763.
  • 53
    Edwards, S. W. and Hallett, M. B., Seeing the wood for the trees: The forgotten role of neutrophils in rheumatoid arthritis. Immunol. Today 1997. 18: 320324.
  • 54
    Larbre, J. P., Moore, A. R., Da Silva, J. A., Iwamura, H., Ioannou, Y. and Willoughby, D. A., Direct degradation of articular cartilage by rheumatoid synovial fluid: Contribution of proteolytic enzymes. J. Rheumatol. 1994. 21: 17961801.
  • 55
    Nordstrom, D., Lindy, O., Konttinen, Y. T., Lauhio, A., Sorsa, T., Friman, C., Pettersson, T. et al., Cathepsin g and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis. Clin. Rheumatol. 1996. 15: 3541.
  • 56
    Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A. et al., The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988. 31: 315324.