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  • 1
    Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995. 155: 11511164.
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    Sakaguchi, S., Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004. 22: 531562.
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    Baecher-Allan, C. and Hafler, D. A., Suppressor T cells in human diseases. J. Exp. Med. 2004. 200: 273276.
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    Tarbell, K. V., Yamazaki, S., Olson, K., Toy, P. and Steinman, R. M., CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 2004. 199: 14671477.
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    Tang, Q., Henriksen, K. J., Bi, M., Finger, E. B., Szot, G., Ye, J., Masteller, E. L., McDevitt, H. et al., In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 2004. 199: 14551465.
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    Jaeckel, E., von Boehmer, H. and Manns, M. P., Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 2005. 54: 306310.
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    Herman, A. E., Freeman, G. J., Mathis, D. and Benoist, C., CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 2004. 199: 14791489.
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    Wu, A. J., Hua, H., Munson, S. H. and McDevitt, H. O., Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA 2002. 99: 1228712292.
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    Klein, L., Khazaie, K. and von Boehmer, H., In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 2003. 100: 88868891.
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    Lee, M. K. t., Moore, D. J., Jarrett, B. P., Lian, M. M., Deng, S., Huang, X., Markmann, J. W. et al., Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation. J. Immunol. 2004. 172: 65396544.
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    Yamazaki, S., Iyoda, T., Tarbell, K., Olson, K., Velinzon, K., Inaba, K. and Steinman, R. M., Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 2003. 198: 235247.
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    Fehervari, Z. and Sakaguchi, S., Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells. Int. Immunol. 2004. 16: 17691780.
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    Vremec, D. and Shortman, K., Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 1997. 159: 565573.
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    Nakano, H., Yanagita, M. and Gunn, M. D., CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 2001. 194: 11711178.
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    Homann, D., Jahreis, A., Wolfe, T., Hughes, A., Coon, B., van Stipdonk, M. J., Prilliman, K. R. et al., CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells. Immunity 2002. 16: 403415.
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    Cohen, J. L., Trenado, A., Vasey, D., Klatzmann, D. and Salomon, B. L., CD4(+)CD25(+) Immunoregulatory T cells: New therapeutics for graft-versus-hHost disease. J. Exp. Med. 2002. 196: 401406.
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    Thornton, A. M. and Shevach, E. M., Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000. 164: 183190.
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    Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J. and Sakaguchi, S., Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 1998. 10: 19691980.
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    Lo, D., Freedman, J., Hesse, S., Palmiter, R. D., Brinster, R. L. and Sherman, L. A., Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur. J. Immunol. 1992. 22: 10131022.
  • 20
    Thornton, A. M. and Shevach, E. M., CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287296.
  • 21
    Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E. et al., Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. 2002. 346: 16921698.
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    Keymeulen, B., Vandemeulebroucke, E., Ziegler, A. G., Mathieu, C., Kaufman, L., Hale, G., Gorus, F. et al., Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N. Engl. J. Med. 2005. 352: 25982608.
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    McDevitt, H., Specific antigen vaccination to treat autoimmune disease. Proc. Natl. Acad. Sci. USA 2004. 101 Suppl 2: 1462714630.
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    Masteller, E. L., Warner, M. R., Tang, Q., Tarbell, K. V., McDevitt, H. and Bluestone, J. A., Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J. Immunol. 2005. 175: 30533059.
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    den Haan, J. M., Lehar, S. M. and Bevan, M. J., CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 2000. 192: 16851696.
  • 26
    Iyoda, T., Shimoyama, S., Liu, K., Omatsu, Y., Akiyama, Y., Maeda, Y., Takahara, K. et al., The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 2002. 195: 12891302.
  • 27
    Belz, G. T., Behrens, G. M., Smith, C. M., Miller, J. F., Jones, C., Lejon, K., Fathman, C. G. et al., The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med. 2002. 196: 10991104.
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    Jiang, S., Camara, N., Lombardi, G. and Lechler, R. I., Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo. Blood 2003. 102: 21802186.
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    Jordan, M. S., Boesteanu, A., Reed, A. J., Petrone, A. L., Holenbeck, A. E., Lerman, M. A., Naji, A. and Caton, A. J., Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2001. 2: 301306.
  • 30
    Hsieh, C. S., Liang, Y., Tyznik, A. J., Self, S. G., Liggitt, D. and Rudensky, A. Y., Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 2004. 21: 267277.
  • 31
    Bensinger, S. J., Bandeira, A., Jordan, M. S., Caton, A. J. and Laufer, T. M., Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J. Exp. Med. 2001. 194: 427438.
  • 32
    Shih, F. F., Mandik-Nayak, L., Wipke, B. T. and Allen, P. M., Massive thymic deletion results in systemic autoimmunity through elimination of CD4+ CD25+ T regulatory cells. J. Exp. Med. 2004. 199: 323335.
  • 33
    van Santen, H. M., Benoist, C. and Mathis, D., Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 2004. 200: 12211230.
  • 34
    Szanya, V., Ermann, J., Taylor, C., Holness, C. and Fathman, C. G., The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 2002. 169: 24612465.
  • 35
    Alyanakian, M. A., You, S., Damotte, D., Gouarin, C., Esling, A., Garcia, C., Havouis, S. et al., Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases. Proc. Natl. Acad. Sci. USA 2003. 100: 1580615811.
  • 36
    Walker, L. S., Chodos, A., Eggena, M., Dooms, H. and Abbas, A. K., Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J. Exp. Med. 2003. 198: 249258.
  • 37
    Fisson, S., Darrasse-Jeze, G., Litvinova, E., Septier, F., Klatzmann, D., Liblau, R. and Salomon, B. L., Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J. Exp. Med. 2003. 198: 737746.
  • 38
    Scott, B., Liblau, R., Degermann, S., Marconi, L. A., Ogata, L., Caton, A. J., McDevitt, H. O. and Lo, D., A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1994. 1: 7383.
  • 39
    Kirberg, J., Baron, A., Jakob, S., Rolink, A., Karjalainen, K. and von Boehmer, H., Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J. Exp. Med. 1994. 180: 2534.
  • 40
    Barrou, B., Bertry-Coussot, L., Morin, S., Sainz, J., Lucas, B., Bitker, M. O., Debre, P. and Lemarchand, P., Prolonged islet allograft survival by adenovirus-mediated transfer of sICAM-1/Ig immunoadhesin gene. Hum. Gene Ther. 2002. 13: 14411450.
  • 41
    Cobbold, S. P., Castejon, R., Adams, E., Zelenika, D., Graca, L., Humm, S. and Waldmann, H., Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 2004. 172: 60036010.