• 1
    Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A., Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products. J. Exp. Med. 1995. 182: 389400.
  • 2
    Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. and Amigorena, S., Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 2002. 20: 621667.
  • 3
    Steinman, R. M., Hawiger, D., Liu, K., Bonifaz, L., Bonnyay, D., Mahnke, K., Iyoda, T. et al., Dendritic cell function in vivo during the steady state: A role in peripheral tolerance. Ann. N. Y. Acad. Sci. 2003. 987: 1525.
  • 4
    Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J. V., Steinman, R. M. and Nussenzweig, M. C., Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 2001. 194: 769779.
  • 5
    Steinman, R. M., Hawiger, D. and Nussenzweig, M. C., Tolerogenic dendritic cells. Annu. Rev. Immunol. 2003. 21: 685711.
  • 6
    Viney, J. L., Mowat, A. M., O'Malley, J. M., Williamson, E. and Fanger, N. A., Expanding dendritic cells in vivo enhances the induction of oral tolerance. J. Immunol. 1998. 160: 58155825.
  • 7
    Williamson, E., Westrich, G. M. and Viney, J. L., Modulating dendritic cells to optimize mucosal immunization protocols. J. Immunol. 1999. 163: 36683675.
  • 8
    Kelsall, B. L. and Rescigno, M., Mucosal dendritic cells in immunity and inflammation. Nat. Immunol. 2004. 5: 10911095.
  • 9
    Kapsenberg, M. L., Dendritic-cell control of pathogen-driven T-cell polarization. Nat. Rev. Immunol. 2003. 3: 984993.
  • 10
    Iwasaki, A. and Kelsall, B. L., Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 1999. 190: 229239.
  • 11
    Iwasaki, A. and Kelsall, B. L., Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J. Exp. Med. 2000. 191: 13811394.
  • 12
    Iwasaki, A. and Kelsall, B. L., Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer's patch dendritic cells. J. Immunol. 2001. 166: 48844890.
  • 13
    MacDonald, T. T., The mucosal immune system. Parasite Immunol. 2003. 25: 235246.
  • 14
    Bell, S. J., Rigby, R., English, N., Mann, S. D., Knight, S. C., Kamm, M. A. and Stagg, A. J., Migration and maturation of human colonic dendritic cells. J. Immunol. 2001. 166: 49584967.
  • 15
    Kraehenbuhl, J. P. and Neutra, M. R., Epithelial M cells: Differentiation and function. Annu. Rev. Cell Dev. Biol. 2000. 16: 301332.
  • 16
    Rescigno, M., Identification of a new mechanism for bacterial uptake at mucosal surfaces, which is mediated by dendritic cells. Pathol. Biol. (Paris) 2003. 51: 6970.
  • 17
    Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M. et al., CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005. 307: 254258.
  • 18
    Huang, F. P., Platt, N., Wykes, M., Major, J. R., Powell, T. J., Jenkins, C. D. and MacPherson, G. G., A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 2000. 191: 435444.
  • 19
    Sato, A., Hashiguchi, M., Toda, E., Iwasaki, A., Hachimura, S. and Kaminogawa, S., CD11b+ Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells. J. Immunol. 2003. 171: 36843690.
  • 20
    Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M. and Von Andrian, U. H., Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 2003. 424: 8893.
  • 21
    Mora, J. R. and von Andrian, U. H., Retinoic acid: An educational “vitamin elixir” for gut-seeking T cells. Immunity 2004. 21: 458460.
  • 22
    Johansson-Lindbom, B. and Agace, W. W., Vitamin A helps gut T cells find their way in the dark. Nat. Med. 2004. 10: 13001301.
  • 23
    Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C. and Song, S. Y., Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004. 21: 527538.
  • 24
    Gullberg, E., Leonard, M., Karlsson, J., Hopkins, A. M., Brayden, D., Baird, A. W. and Artursson, P., Expression of specific markers and particle transport in a new human intestinal M-cell model. Biochem. Biophys. Res. Commun. 2000. 279: 808813.
  • 25
    Kerneis, S., Bogdanova, A., Kraehenbuhl, J. P. and Pringault, E., Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 1997. 277: 949952.
  • 26
    Sauter, B., Albert, M. L., Francisco, L., Larsson, M., Somersan, S. and Bhardwaj, N., Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J. Exp. Med. 2000. 191: 423434.
  • 27
    Fadok, V. A., Bratton, D. L. and Henson, P. M., Phagocyte receptors for apoptotic cells: Recognition, uptake, and consequences. J. Clin. Invest. 2001. 108: 957962.
  • 28
    Fadok, V. A., McDonald, P. P., Bratton, D. L. and Henson, P. M., Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells. Biochem. Soc. Trans. 1998. 26: 653656.
  • 29
    Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y. and Henson, P. M., Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 1998. 101: 890898.
  • 30
    Albert, M. L., Death-defying immunity: Do apoptotic cells influence antigen processing and presentation? Nat. Rev. Immunol. 2004. 4: 223231.
  • 31
    Weiner, H. L., Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 2001. 182: 207214.
  • 32
    Weiner, H. L., Oral tolerance: Immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect. 2001. 3: 947954.
  • 33
    Strobl, H. and Knapp, W., TGF-beta1 regulation of dendritic cells. Microbes Infect. 1999. 1: 12831290.
  • 34
    Bilsborough, J. and Viney, J. L., Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology 2004. 127: 300309.
  • 35
    Jiang, H. Q., Thurnheer, M. C., Zuercher, A. W., Boiko, N. V., Bos, N. A. and Cebra, J. J., Interactions of commensal gut microbes with subsets of B- and T-cells in the murine host. Vaccine 2004. 22: 805811.
  • 36
    Cebra, J. J., Influences of microbiota on intestinal immune system development. Am. J. Clin. Nutr. 1999. 69: 1046S–1051S.
  • 37
    Talham, G. L., Jiang, H. Q., Bos, N. A. and Cebra, J. J., Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infect. Immun. 1999. 67: 19922000.
  • 38
    Cebra, J. J., Periwal, S. B., Lee, G., Lee, F. and Shroff, K. E., Development and maintenance of the gut-associated lymphoid tissue (GALT): The roles of enteric bacteria and viruses. Dev. Immunol. 1998. 6: 1318.
  • 39
    Rigby, R. J., Knight, S. C., Kamm, M. A. and Stagg, A. J., Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli. Clin. Exp. Immunol. 2005. 139: 245256.
  • 40
    Ruedl, C., Rieser, C., Bock, G., Wick, G. and Wolf, H., Phenotypic and functional characterization of CD11c+ dendritic cell population in mouse Peyer's patches. Eur. J. Immunol. 1996. 26: 18011806.
  • 41
    Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R. et al., Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992. 359: 693699.
  • 42
    Fu, S., Zhang, N., Yopp, A. C., Chen, D., Mao, M., Zhang, H., Ding, Y. and Bromberg, J. S., TGF-beta induces Foxp3+ T-regulatory cells from CD4+ CD25 precursors. Am. J. Transplant. 2004. 4: 16141627.
  • 43
    Chen, W., Jin, W., Hardegen, N., Lei, K. J., Li, L., Marinos, N., McGrady, G. and Wahl, S. M., Conversion of peripheral CD4+CD25 naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003. 198: 18751886.
  • 44
    Gorelik, L. and Flavell, R. A., Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol. 2002. 2: 4653.
  • 45
    Hart, A. L., Lammers, K., Brigidi, P., Vitali, B., Rizzello, F., Gionchetti, P., Campieri, M. et al., Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 2004. 53: 16021609.
  • 46
    McCartney-Francis, N., Jin, W. and Wahl, S. M., Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway. J. Immunol. 2004. 172: 38143821.
  • 47
    Hart, A. L., Al-Hassi, H. O., Rigby, R. J., Bell, S. J., Emmanuel, A. V., Knight, S. C., Kamm, M. A. and Stagg, A. J., Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 2005. 129: 5065.
  • 48
    Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. and Medzhitov, R., Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004. 118: 229241.
  • 49
    Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G. M., Nespoli, A. et al., Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat. Immunol. 2005. 6: 507514.
  • 50
    Watanabe, N., Hanabuchi, S., Marloie-Provost, M. A., Antonenko, S., Liu, Y. J. and Soumelis, V., Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential. Blood 2005. 105: 47494751.
  • 51
    Ying, S., O'Connor, B., Ratoff, J., Meng, Q., Mallett, K., Cousins, D., Robinson, D. et al., Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J. Immunol. 2005. 174: 81838190.
  • 52
    Rimoldi, M., Chieppa, M., Larghi, P., Vulcano, M., Allavena, P. and Rescigno, M., Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different. Blood 2005. 106: 28182826.
  • 53
    Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K. et al., Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 2003. 278: 55095512.