• 1
    Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245252.
  • 2
    Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A., Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 1995. 182: 389400.
  • 3
    Janeway, C., The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 1992. 13: 1116.
  • 4
    Akira, S., Toll-like receptors: lessons from knockout mice. Biochem. Soc. Trans. 2000. 28: 551556.
  • 5
    Akira, S., Toll receptor families: structure and function. Semin. Immunol. 2004. 16: 12.
  • 6
    Figdor, C. G., van Kooyk, Y. and Adema, G. J., C-type lectin receptors on dendritic cells and Langerhans cells. Nat. Rev. Immunol. 2002. 2: 7784.
  • 7
    Huang, Q., Liu, D., Majewski, P., Schulte, L. C., Korn, J. M., Young, R. A., Lander, E. S. and Hacohen, N., The plasticity of dendritic cell responses to pathogens and their components. Science 2001. 294: 870875.
  • 8
    Krieger, M. and Herz, J., Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu. Rev. Biochem. 1994. 63: 601637.
  • 9
    Pearson, A. M., Scavenger receptors in innate immunity. Curr. Opin. Immunol. 1996. 8: 2028.
  • 10
    Platt, N., Haworth, R., Darley, L. and Gordon, S., The many roles of the class A macrophage scavenger receptor. Int. Rev. Cytol. 2002. 212: 140.
  • 11
    Platt, N. and Gordon, S., Is the class A macrophage scavenger receptor (SR-A) multifunctional? - the mouse's tale. J. Clin. Invest. 2001. 108: 649654.
  • 12
    Platt, N. and Gordon, S., Scavenger receptors: diverse activities and promiscuous binding of polyanionic ligands. Chem. Biol. 1998. 5: R193203.
  • 13
    Abraham, R., Singh, N., Mukhopadhyay, A., Basu, S. K., Bal, V. and Rath, S., Modulation of immunogenicity and antigenicity of proteins by maleylation to target scavenger receptors on macrophages. J. Immunol. 1995. 154: 18.
  • 14
    Abraham, R., Choudhury, A., Basu, S. K., Bal, V. and Rath, S., Disruption of T cell tolerance by directing a self antigen to macrophage-specific scavenger receptors. J. Immunol. 1997. 158: 40294035.
  • 15
    Singh, N., Bhatia, S., Abraham, R., Basu, S. K., George, A., Bal, V. and Rath, S., Modulation of T cell cytokine profiles and peptide-MHC complex availability in vivo by delivery to scavenger receptors via antigen maleylation. J. Immunol 1998. 160: 48694880.
  • 16
    Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. and Steinman, R. M., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 1992. 176: 16931702.
  • 17
    Platt, N., Suzuki, H., Kurihara, Y., Kodama, T. and Gordon, S., Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc. Natl. Acad. Sci. USA 1996. 93: 1245612460.
  • 18
    Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O. et al., A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 1997. 386: 292296.
  • 19
    Hughes, D. A., Fraser, I. P. and Gordon, S., Murine macrophage scavenger receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs. Eur. J. Immunol. 1995. 25: 466473.
  • 20
    Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B. and Palucka, K., Immunobiology of dendritic cells. Annu. Rev. Immunol. 2000. 18: 767811.
  • 21
    Brawand, P., Fitzpatrick, D. R., Greenfield, B. W., Brasel, K., Maliszewski, C. R. and De Smedt, T., Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APC. J. Immunol. 2002. 169: 67116719.
  • 22
    Gilliet, M., Boonstra, A., Paturel, C., Antonenko, S., Xu, X. L., Trinchieri, G., O'Garra, A. and Liu, Y. J., The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 2002. 195: 953958.
  • 23
    McLellan, A. D., Kapp, M., Eggert, A., Linden, C., Bommhardt, U., Brocker, E. B., Kammerer, U. and Kampgen, E., Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression. Blood 2002. 99: 20842093.
  • 24
    Akira, S., Mammalian Toll-like receptors. Curr. Opin. Immunol. 2003. 15: 511.
  • 25
    Brown, G. D., Taylor, P. R., Reid, D. M., Willment, J. A., Williams, D. L., Martinez-Pomares, L., Wong, S. Y. and Gordon, S., Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp. Med. 2002. 196: 407412.
  • 26
    Peiser, L., Gough, P. J., Kodama, T. and Gordon, S., Macrophage class A scavenger receptor-mediated phagocytosis of Escherichia coli: role of cell heterogeneity, microbial strain, and culture conditions in vitro. Infect. Immun. 2000. 68: 19531963.
  • 27
    Shortman, K. and Liu, Y. J., Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2002. 2: 151161.
  • 28
    Diebold, S. S., Montoya, M., Unger, H., Alexopoulou, L., Roy, P., Haswell, L. E., Al-Shamkhani, A. et al., Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 2003. 424: 324328.
  • 29
    Kadowaki, N., Ho, S., Antonenko, S., Malefyt, R. W., Kastelein, R. A., Bazan, F. and Liu, Y. J., Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 2001. 194: 863869.
  • 30
    Edwards, A. D., Diebold, S. S., Slack, E. M., Tomizawa, H., Hemmi, H., Kaisho, T., Akira, S. and Reis e Sousa, C., Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 2003. 33: 827833.
  • 31
    Iyoda, T., Shimoyama, S., Liu, K., Omatsu, Y., Akiyama, Y., Maeda, Y., Takahara, K. et al., The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 2002. 195: 12891302.
  • 32
    Harshyne, L. A., Zimmer, M. I., Watkins, S. C. and Barratt-Boyes, S. M., A role for class A scavenger receptor in dendritic cell nibbling from live cells. J. Immunol. 2003. 170: 23022309.
  • 33
    Urban, B. C., Willcox, N. and Roberts, D. J., A role for CD36 in the regulation of dendritic cell function. Proc. Natl. Acad. Sci. USA 2001. 98: 87508755.
  • 34
    Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N. et al., Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 2002. 17: 353362.
  • 35
    Asselin-Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter-Dambuyant, C., Vicari, A. et al., Mouse type I IFN-producing cells are immature APC with plasmacytoid morphology. Nat. Immunol 2001. 2: 11441150.
  • 36
    Nakano, H., Yanagita, M. and Gunn, M. D., CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 2001. 194: 11711178.
  • 37
    Alferink, J., Lieberam, I., Reindl, W., Behrens, A., Weiss, S., Huser, N., Gerauer, K. et al., Compartmentalized production of CCL17 invivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J. Exp. Med. 2003. 197: 585599.
  • 38
    Martinez del Hoyo, G., Martin, P., Arias, C. F., Marin, A. R. and Ardavin, C., CD8alpha+ dendritic cells originate from the CD8alpha dendritic cell subset by a maturation process involving CD8alpha, DEC-205, and CD24 up-regulation. Blood 2002. 99: 9991004.
  • 39
    Granucci, F., Petralia, F., Urbano, M., Citterio, S., Di Tota, F., Santambrogio, L. and Ricciardi-Castagnoli, P., The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia. Blood 2003. 102: 29402947.
  • 40
    Rogers, N. C., Slack, E. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L. et al., Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005. 22: 507517.
  • 41
    Chieppa, M., Bianchi, G., Doni, A., Del Prete, A., Sironi, M., Laskarin, G., Monti, P. et al., Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J. Immunol. 2003. 171: 45524560.
  • 42
    Haworth, R., Platt, N., Keshav, S., Hughes, D., Darley, E., Suzuki, H., Kurihara, Y. et al., The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J. Exp. Med. 1997. 186: 14311439.
  • 43
    Fujii, S., Liu, K., Smith, C., Bonito, A. J. and Steinman, R. M., The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J. Exp. Med. 2004. 199: 16071618.
  • 44
    Zal, T., Volkmann, A. and Stockinger, B., Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J. Exp. Med. 1994. 180: 20892099.
  • 45
    Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V. et al., Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA 1993. 90: 35393543.
  • 46
    Yrlid, U., Svensson, M., Hakansson, A., Chambers, B. J., Ljunggren, H. G. and Wick, M. J., In vivo activation of dendritic cells and T cells during Salmonella enterica serovar Typhimurium infection. Infect. Immun. 2001. 69: 57265735.