Is long-term humoral immunity in the mucosa provided by long-lived plasma cells? A question still open

Authors

  • Falk Hiepe,

    Corresponding author
    1. Charité – Universitätsmedizin Berlin, Berlin, Germany
    2. German Rheumatism Research Centre Berlin, Berlin, Germany
    • Charité – Universitätsmedizin Berlin, Schumannstrasse 20/21, D-10117 Berlin, Germany, Fax: +49-30-450 513922
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  • Andreas Radbruch

    1. Charité – Universitätsmedizin Berlin, Berlin, Germany
    2. German Rheumatism Research Centre Berlin, Berlin, Germany
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Abstract

The biology of antibody-secreting cells is still a matter of controversial discussion. One of the key questions is how the migration and lifespan of antibody-secreting cells is linked to their generation. A paper in this issue of the European Journal of Immunology provides further information on the generation of long-term mucosal immune responses; however, the study leaves many questions unanswered as discussed in this brief Commentary.

See accompanying article http://dx.doi.ORG/10.1002/eji.200535493

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